2017
DOI: 10.1007/s11745-017-4251-4
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Acute Fasting Induces Expression of Acylglycerophosphate Acyltransferase (AGPAT) Enzymes in Murine Liver, Heart, and Brain

Abstract: During fasting, cells increase uptake of non-esterified fatty acids (NEFA) and esterify excess into phosphatidic acid (PtdOH), the common precursor of both triacylglycerols and phospholipids, using acylglycerophosphate acyltransferases/lysophosphatidic acid acyltransferases (AGPAT/LPAAT). Knowledge of the regulation of AGPAT enzymes is important for understanding fasting adaptations. Total RNA was isolated from liver, heart, and whole brain tissue of C57BL/6J mice fed ad libitum, or fasted for 16 h. Following … Show more

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Cited by 11 publications
(7 citation statements)
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References 36 publications
(34 reference statements)
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“…At the time of submission, however, Lpar6 −/− mice were not available to our laboratory for examination. In agreement with prior studies (Bradley et al, ; Mardian et al, ), this work highlights the molecular heterogeneity of the various WAT depots, and suggests that significant variation in the predominant expression of Lpar homologues could be important in determining differences in the metabolic characteristics of these depots and the groups ( e.g . visceral, subcutaneous) that they belong to.…”
Section: Resultssupporting
confidence: 92%
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“…At the time of submission, however, Lpar6 −/− mice were not available to our laboratory for examination. In agreement with prior studies (Bradley et al, ; Mardian et al, ), this work highlights the molecular heterogeneity of the various WAT depots, and suggests that significant variation in the predominant expression of Lpar homologues could be important in determining differences in the metabolic characteristics of these depots and the groups ( e.g . visceral, subcutaneous) that they belong to.…”
Section: Resultssupporting
confidence: 92%
“…We subjected mice to an overnight fast initiated at the beginning of the light cycle. Because mice are nocturnal and exhibit most of their feeding and activity in the dark cycle, this paradigm is analogous to overnight fasting in humans (Bradley et al, ). Fasting rats for 12–24 h has been shown to significantly decrease total plasma circulating lysoPtdOH concentrations by more than half, with changes occurring in specific lysoPtdOH species (Ino et al, ).…”
Section: Resultsmentioning
confidence: 99%
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“…The glycerophosphate pathway is an important pathway for de novo synthesis of triglycerides, and AGPAT2 plays a key role in the synthesis of glycerolipid and triglyceride. As a precursor of de novo synthesis of major glycerides (Bradley et al, 2017), it is highly expressed in adipose tissue and liver and can catalyze the formation of triglycerides (Fernandez-Galilea et al, 2015). AGPAT2 mutation can lead to congenital systemic adipotrophic diabetes (GCL), which is characterized by adipose tissue deficiency, insulin resistance, diabetes, and hyperlipidemia (Oswiecimska et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…To date, 11 AGPATs have been identified in mice and humans, although only AGPAT1 to -5 preferentially utilize lysophosphatidic acid (LPA) as an acyl donor, while AGPAT6 to -11 have been reclassified based on alternate lysophospholipid substrate preferences, or preference for glycerol-3-phosphate. Thus, of the 11 known AGPAT family members, only AGPAT1 to -5 function as true LPAATs (3,4).…”
mentioning
confidence: 99%