Acute fasting increases somatodendritic dopamine release in the ventral tegmental area

Roseberry, Aaron G.

doi:10.1152/jn.01008.2014

Cited by 29 publications

(18 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Leptin has been shown to modulate mesolimbic DA system via activating LepR‐containing LH neurons . Earlier research reported fasting can promote expression of TH, a catecholamine biosynthesis‐mediated enzyme, and DA release . However, in present study, we observed a reduction of TH expression of hypothalamus in fasted mice, indicating that the role of catecholaminergic neurons played in fasting‐induced overeating needs to be further investigated.…”

Section: Discussioncontrasting

confidence: 73%

Role of leptin in the regulation of food intake in fasted mice

Yao

Zhao

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

Leptin is well acknowledged as an anorexigenic hormone that plays an important role in feeding control. Hypothalamic GABA system plays a significant role in leptin regulation on feeding and metabolism control. However, the pharmacological relationship of leptin and GABA receptor is still obscure. Therefore, we investigated the effect of leptin or combined with baclofen on the food intake in fasted mice. We detected the changes in hypothalamic c-Fos expression, hypothalamic TH, POMC and GAD67 expression, plasma insulin, POMC and GABA levels to demonstrate the mechanisms.We found that leptin inhibit fasting-induced increased food intake and activated hypothalamic neurons. The inhibitory effect on food intake induced by leptin in fasted mice can be reversed by pretreatment with baclofen. Baclofen reversed leptin's inhibition on c-Fos expression of PAMM in fasted mice. Therefore, these results indicate that leptin might inhibit fasting-triggered activation of PVN neurons via presynaptic GABA synaptic functions which might be partially blocked by pharmacological activating GABA-B. Our findings identify the role of leptin in the regulation of food intake. K E Y W O R D S baclofen, feeding behaviour, GABA-B, hypothalamus, leptin | 4525 GE Et al.

show abstract

Section: Discussioncontrasting

confidence: 73%

Role of leptin in the regulation of food intake in fasted mice

Yao

Zhao

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…2 D ), which indicates that the deficit in the self-administration paradigm primarily is related to cocaine. We should note, however, that mice were food restricted during the liquid food self-administration experiments, which, according to previous investigations, might affect DA dynamics ( Roseberry, 2015 ; Jones et al, 2017 ).…”

Section: Resultsmentioning

confidence: 88%

PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis

Jensen

Sørensen

Dencker

et al. 2018

eNeuro

View full text Add to dashboard Cite

Protein interacting with C-kinase 1 (PICK1) is a widely expressed scaffold protein known to interact via its PSD-95/discs-large/ZO-1 (PDZ)-domain with several membrane proteins including the dopamine (DA) transporter (DAT), the primary target for cocaine’s reinforcing actions. Here, we establish the importance of PICK1 for behavioral effects observed after both acute and repeated administration of cocaine. In PICK1 knock-out (KO) mice, the acute locomotor response to a single injection of cocaine was markedly attenuated. Moreover, in support of a role for PICK1 in neuroadaptive changes induced by cocaine, we observed diminished cocaine intake in a self-administration paradigm. Reduced behavioral effects of cocaine were not associated with decreased striatal DAT distribution and most likely not caused by the ∼30% reduction in synaptosomal DA uptake observed in PICK1 KO mice. The PICK1 KO mice demonstrated preserved behavioral responses to DA receptor agonists supporting intact downstream DA receptor signaling. Unexpectedly, we found a prominent increase in striatal DA content and levels of striatal tyrosine hydroxylase (TH) in PICK1 KO mice. Chronoamperometric recordings showed enhanced DA release in PICK1 KO mice, consistent with increased striatal DA pools. Viral-mediated knock-down (KD) of PICK1 in cultured dopaminergic neurons increased TH expression, supporting a direct cellular effect of PICK1. In summary, in addition to demonstrating a key role of PICK1 in mediating behavioral effects of cocaine, our data reveal a so far unappreciated role of PICK1 in DA homeostasis that possibly involves negative regulation of striatal TH levels.

show abstract

“…We hypothesize that at least some of the inconsistencies in the literature related to DA signaling in obesity (reviewed by Dang, L et al) [7] are due to metabolic variation within obese cohorts. Other specifics of our protocol including weight stability, restraining from exercise [23] before imaging, fasting pre-scan [24], and evening scan times [25] are also posited to contribute to our findings as pre-clinical studies support these as relevant modifiers of DA signaling. The modification of the relationship between DI and D2/3R binding by ghrelin support both the relevance of fasting, when ghrelin reaches its peak, and the known effects of ghrelin on DA mediated reward signaling [1].…”

Section: Discussionmentioning

confidence: 99%

Brief communication: β-cell function influences dopamine receptor availability

et al. 2019

View full text Add to dashboard Cite

We aim to identify physiologic regulators of dopamine (DA) signaling in obesity but previously did not find a compelling relationship with insulin sensitivity measured by oral-minimal model (OMM) and DA subtype 2 and 3 receptor (D2/3R) binding potential (BP ND ). Reduced disposition index (DI), a β-cell function metric that can also be calculated by OMM, was shown to predict a negative reward behavior that occurs in states of lower endogenous DA. We hypothesized that reduced DI would occur with higher D2/3R BP ND , reflecting lower endogenous DA. Participants completed PET scanning, with a displaceable radioligand to measure D2/3R BP ND , and a 5-hour oral glucose tolerance test to measure DI by OMM. We studied 26 age-similar females without (n = 8) and with obesity (n = 18) (22 vs 39 kg/m 2 ). Reduced DI predicted increased striatal D2/3R BP ND independent of BMI. By accounting for β-cell function, we were able to determine that the state of insulin and glucose metabolism is pertinent to striatal D2/3R BP ND in obesity. Clinical Trial Registration Number : NCT00802204

show abstract

Acute fasting increases somatodendritic dopamine release in the ventral tegmental area

Abstract: Roseberry AG. Acute fasting increases somatodendritic dopamine release in the ventral tegmental area.

Cited by 29 publications

References 40 publications

Role of leptin in the regulation of food intake in fasted mice

Role of leptin in the regulation of food intake in fasted mice

PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis

Brief communication: β-cell function influences dopamine receptor availability

Contact Info

Product

Resources

About