Acute eye movement-retained internal ophthalmoplegia in atypical Miller Fisher syndrome variants are associated with IgG anti-GQ1b antibodies

Murakami, Keishu; Miyamoto, Katsuichi; Terayama, Atsushi; Yoshikawa, Ken; Kuwahara, Motoi; Ito, Hidefumi

doi:10.1016/j.jneuroim.2022.577880

Cited by 1 publication

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“…GQ1b gangliosides are expressed in the extraocular neuromuscular junctions, extraocular muscle spindles, and paranodal regions of the extraocular cranial nerves ( 1 , 2 ). Anti-GQ1b antibodies targeted to these regions develop in response to similar antigens from invading pathogens, such as Campylobacter jejuni , Cytomegalovirus, Epstein–Barr virus, or Mycoplasma pneumoniae ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Case Report: Isolated facial and trigeminal nerve palsy without ataxia in anti-GQ1b antibody syndrome secondary to Mycoplasma pneumonia

Deng

et al. 2022

Front. Immunol.

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The presence of anti-GQ1b antibodies in serum or cerebrospinal fluid is a diagnostic indicator of the Miller–Fisher variant of Guillain–Barré syndrome (GBS), whereas anti-GQ1b antibody syndrome is rarely presented as acute bilateral pain in the cheeks and masticatory muscle fatigue without ophthalmoplegia, ataxia, or limb weakness. Here, we report a case of a female patient diagnosed with GBS characterized only by the involvement of the facial and trigeminal nerves who was positive for serum anti-GQ1b antibodies secondary to Mycoplasma pneumoniae infection. The patient was treated with macrolide antibiotics and neurotrophic drugs, and her symptoms were significantly alleviated after 1 month. This case indicates a new clinical presentation of GBS and anti-GQ1b antibody syndrome with a differential diagnosis of multiple cranial nerve damage of which neurological physicians should be aware. Positive anti-GQ1b antibodies secondary to infection were observed in this case, and antibiotic treatment resulted in a favorable prognosis. The specific underlying mechanism requires further investigation.

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Section: Introductionmentioning

confidence: 99%

Case Report: Isolated facial and trigeminal nerve palsy without ataxia in anti-GQ1b antibody syndrome secondary to Mycoplasma pneumonia

Deng

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

show abstract

Acute eye movement-retained internal ophthalmoplegia in atypical Miller Fisher syndrome variants are associated with IgG anti-GQ1b antibodies

Cited by 1 publication

References 16 publications

Case Report: Isolated facial and trigeminal nerve palsy without ataxia in anti-GQ1b antibody syndrome secondary to Mycoplasma pneumonia

Case Report: Isolated facial and trigeminal nerve palsy without ataxia in anti-GQ1b antibody syndrome secondary to Mycoplasma pneumonia

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