2022
DOI: 10.3390/ijms232314916
|View full text |Cite
|
Sign up to set email alerts
|

Acute Exposure to Glycated Proteins Impaired in the Endothelium-Dependent Aortic Relaxation: A Matter of Oxidative Stress

Abstract: Chronically increased levels of high molecular weight advanced glycation end products (HMW-AGEs) are known to induce cardiovascular dysfunction. Whether an acute increase in HMW-AGE levels affects vascular function remains unknown. In this study, we examined whether acute exposure to HMW-AGEs disturbs aortic vasomotor function. Aortae were obtained from healthy male rats and were acutely pre-treated with HMW-AGEs in organ baths. Aortic relaxation responses to cumulative doses of acetylcholine (ACh), in the pre… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2023
2023
2023
2023

Publication Types

Select...
1

Relationship

1
0

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 57 publications
(79 reference statements)
0
1
0
Order By: Relevance
“…AGEs are complex compounds formed by the irreversible glycation of amino acids, peptides or proteins [ 100 ]. A heat-treated diet high in sugar content can be an exogenous source of AGEs, whereas they also accumulate with aging in the blood and tissues, including the aorta and heart [ 101 , 102 , 103 ]. In the heart, AGEs exert detrimental effects by cross-linking ECM proteins in the presence or absence of LOX, thereby causing myocardial fibrosis and stiffening.…”
Section: Discussionmentioning
confidence: 99%
“…AGEs are complex compounds formed by the irreversible glycation of amino acids, peptides or proteins [ 100 ]. A heat-treated diet high in sugar content can be an exogenous source of AGEs, whereas they also accumulate with aging in the blood and tissues, including the aorta and heart [ 101 , 102 , 103 ]. In the heart, AGEs exert detrimental effects by cross-linking ECM proteins in the presence or absence of LOX, thereby causing myocardial fibrosis and stiffening.…”
Section: Discussionmentioning
confidence: 99%