Acute exposure to environmentally relevant concentrations of benzophenone-3 induced genotoxicity in Poecilia reticulata

Almeida, Sara dos Santos; Rocha, Thiago Lopes; Qualhato, Gabriel; Oliveira, Leandra de Almeida Ribeiro; Amaral, Cátia Lira do; Conceição, Edemilson Cardoso da; Sabóia‐Morais, Simone Maria Teixeira de; Bailão, Elisa Flávia Luiz Cardoso

doi:10.1016/j.aquatox.2019.105293

Cited by 40 publications

(16 citation statements)

References 52 publications

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“…Erythrocyte nuclear morphology has been sucefully used in P. reticulata as biomarker for mutagenicity promoted by aquatic pollutants. 29,44,45 In this study, in addition to DNA damage assessment by the comet assay, we also evaluated the mutagenicity of CYN in the blood tissue of P. reticulata by MN test. Such approach is internationally recommended to assess genotoxicity in studies where in vivo acute expositions are employed.…”

Section: Discussionmentioning

confidence: 99%

DNA damage induced by cylindrospermopsin on different tissues of the biomonitor fish Poecilia reticulata

Rabelo

Hanusch

Jesus

et al. 2021

Environmental Toxicology

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The cyanotoxin cylindrospermopsin (CYN) is the second biggest cause of poisoning worldwide, both in humans and animals. Although CYN primarily affects the aquatic environments and can be absorbed in fishes by multiple routes, data reporting its toxicity and mechanism of action are still scarce in this group. Using P. reticulata as model species, it was evaluated whether CYN promotes mutagenic and genotoxic effects in different fish target tissues. Adult females were exposed in a static way to 0 (control), 0.5, 1.0, and 1.5 μg L −1 of pure CYN for 24 and 96 hours. For the first time, DNA damage was detected in fish brain after CYN exposition. In brain cells, a concentrationresponse DNA damage was observed for both exposure times, suggesting a direct or indirect action of CYN in neurotoxicity. For the liver cells, 96 hours caused an increase in DNA damage, as well the highest percentage of DNA in the tail was reached when used 1.5 μg L −1 of CYN. In peripheral blood cells, an increase in DNA damage was observed for all tested concentrations after 96 hours. In erythrocytes, micronuclei frequency was higher at 1.5 μg L −1 treatment while the erythrocyte nuclear abnormalities (ENA) frequency was significantly higher even at the lowest CYN concentration. Such data demonstrated that acute exposition to CYN promotes genotoxicity in the brain, liver, and blood cells of P. reticulata, as well mutagenicity in erythrocytes. It rises an alert regarding to the toxic effects of CYN for aquatic organisms as well as for human health.

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Section: Discussionmentioning

confidence: 99%

DNA damage induced by cylindrospermopsin on different tissues of the biomonitor fish Poecilia reticulata

Rabelo

Hanusch

Jesus

et al. 2021

Environmental Toxicology

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“…Interactions between genes and environmental factors during early life are suggested to play an important role in the development and health of an adult individual. So far, the knowledge about geno-and developmental toxicity of BP-3 is poor, and what we know comes mostly from the research carried out on water organisms or in cell cultures [42][43][44][45].…”

Section: Bp-3 and Genotoxicity/developmental Toxicitymentioning

confidence: 99%

“…An acute exposure to environmentally relevant concentrations of BP-3 induced genotoxic and mutagenic effects, leading to erythrotoxicity in freshwater fish Poecilia reticulata [ 42 ]. The exposure of embryo zebrafish ( Danio rerio ) to low concentrations of BP-3 resulted in the alteration of multiple gene expression in the brain and testes, which can trigger an antiandrogenic activity [ 43 ].…”

Section: The Potential Toxic Effects Of Benzophenone-3 On Human Healthmentioning

confidence: 99%

Benzophenone-3, a chemical UV-filter in cosmetics: is it really safe for children and pregnant women?

Wnuk¹,

Michalska²,

Krupa³

et al. 2022

pdia

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Children and adolescents are particularly vulnerable to skin damage caused by ultraviolet radiation and require intensified photoprotection. Benzophenone-3 (BP-3) belongs to the organic sunscreens, which are widely used in personal care and cosmetic products. However, the impact of BP-3 on human health requires a careful assessment. This review focuses on potentially harmful effect of this compound in relation to the developing organism. Studies show that BP-3, after topical application, can penetrate into bloodstream, blood-brain barrier and blood-placental barrier and may induce the reproductive toxicity and abnormal development of the foetus, endocrine system disruption and neurotoxicity in experimental animal models. So far, human studies have been scarce and controversial, therefore the cosmetics containing BP-3 should be carefully used by the pregnant women, children and adolescents.

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“…COX-2, TNFα, and IL-8), and inhibited the development of the epidermal permeability barrier (Kim et al, 2018). Moreover, acute exposures to environmentally relevant concentrations of benzophenone-3 induced genotoxicity and mutagenesis in Poecilia reticulata by inducing DNA damages and nuclear abnormalities in the erythrocytes (Almeida et al, 2019). There is no information about the benzophenone-3 on promotion/progression of the skin cancer, but lately benzophenone-3 has been found to promote mammary tumorigenesis and to increase metastasis in lung cancer cells via epithelial to mesenchymal transition (Phiboonchaiyanan et al, 2017;Kariagina et al, 2020).…”

Section: Exposure Routes Of the Human Body To Benzophenone-3mentioning

confidence: 99%

“…Benzophenone-3 has also been shown to increase uterine weight in ovariectomized rat females (Schlumpf et al, 2001;Schlecht et al, 2004;Suzuki et al, 2005). The effect of benzophenone-3 on steroid hormones is not limited to direct effects on hormones but also involves damage to DNA fragments through a mechanism dependent on ERα estrogen receptors (Almeida et al, 2019;Majhi et al, 2020). The latest data from zebrafish show that benzophenone-3 affects estradiol biosynthesis, sex differentiation and gonadotropin-releasing hormone levels.…”

Section: Effects Of Benzophenone-3 On the Endocrine Systemsmentioning

confidence: 99%

Is the commonly used UV filter benzophenone-3 a risk factor for the nervous system?

Wnuk

Kajta

2021

Acta Biochim Pol

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Benzophenone-3 (2-hydroxy-4-methoxybenzophenone, oxybenzone, or BP-3) is one of the most frequently used UV radiation absorbents, which are commonly referred to as sunscreen filters. Its widespread use in industrial applications provides protection against the photodegradation of a wide range of products but at the same time creates the risk of human exposure to benzophenone-3 unbeknownst to the individuals exposed. Topically applied benzophenone-3 penetrates individual skin layers, enters the bloodstream, and is excreted in the urine. In addition, benzophenone-3 easily crosses the placental barrier, which creates the risk of exposure to this substance in the prenatal period. Despite the widespread use and occurrence of benzophenone-3 in the human environment, little knowledge of the mechanisms underlying the effect of benzophenone-3 on the nervous system was available until recently. Only the most recent research, including studies by our group, has enabled the identification of new molecular mechanisms through which benzophenone-3 affects embryonic neuronal cells and the developing mammalian brain. Benzophenone-3 has been shown to induce neurotoxicity and apoptotic processes and inhibit autophagy in embryonic neuronal cells. Benzophenone-3 also alters expression and impairs function of receptors necessary for the proper development and function of the nervous system. The most worrying finding seems to be that benzophenone-3 contributes to an increased risk of developmental abnormalities and/or epigenetically based degeneration of neuronal cells by changing the epigenetic status of neuronal cells.

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Acute exposure to environmentally relevant concentrations of benzophenone-3 induced genotoxicity in Poecilia reticulata

Cited by 40 publications

References 52 publications

DNA damage induced by cylindrospermopsin on different tissues of the biomonitor fish Poecilia reticulata

DNA damage induced by cylindrospermopsin on different tissues of the biomonitor fish Poecilia reticulata

Benzophenone-3, a chemical UV-filter in cosmetics: is it really safe for children and pregnant women?

Is the commonly used UV filter benzophenone-3 a risk factor for the nervous system?

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