Acute exposure to diesel and sewage biodiesel exhaust causes pulmonary and systemic inflammation in mice

Brito, Jôse Mára de; Mauad, Thaís; Cavalheiro, Guilherme Franco; Yoshizaki, Kelly; André, Paulo Afonso de; Lichtenfels, A.J.F.C.; Guimarães, Eliane Tigre; Rivero, Dolores Helena Rodriguez Ferreira; Antonângelo, Leila; Oliveira, Luciano Basto; Pedroso, Luiz Roberto Martins; Macchione, Mariângela; Saldiva, Paulo Hilário Nascimento

doi:10.1016/j.scitotenv.2018.02.019

Cited by 40 publications

(23 citation statements)

References 44 publications

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“…89,95 This finding suggests that the adjuvant effect might rely on repetitive exposures. A recent mouse study 96 compared the effects of a two-hour exposure to DE or to the allegedly less toxic biodiesel (BD). Both exhaust products induced cardiovascular and pulmonary inflammation, while only BD generated an increase of neutrophils in bronchoalveolar lavage.…”

Section: Environmental-human Interactionsmentioning

confidence: 99%

The need for clean air: The way air pollution and climate change affect allergic rhinitis and asthma

Eguiluz‐Gracia

Mathioudakis

Bartel

et al. 2020

Allergy

285

193

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Air pollution and climate change have a significant impact on human health and well‐being and contribute to the onset and aggravation of allergic rhinitis and asthma among other chronic respiratory diseases. In Westernized countries, households have experienced a process of increasing insulation and individuals tend to spend most of their time indoors. These sequelae implicate a high exposure to indoor allergens (house dust mites, pets, molds, etc), tobacco smoke, and other pollutants, which have an impact on respiratory health. Outdoor air pollution derived from traffic and other human activities not only has a direct negative effect on human health but also enhances the allergenicity of some plants and contributes to global warming. Climate change modifies the availability and distribution of plant‐ and fungal‐derived allergens and increases the frequency of extreme climate events. This review summarizes the effects of indoor air pollution, outdoor air pollution, and subsequent climate change on asthma and allergic rhinitis in children and adults and addresses the policy adjustments and lifestyle changes required to mitigate their deleterious effects.

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Section: Environmental-human Interactionsmentioning

confidence: 99%

The need for clean air: The way air pollution and climate change affect allergic rhinitis and asthma

Eguiluz‐Gracia

Mathioudakis

Bartel

et al. 2020

Allergy

285

193

View full text Add to dashboard Cite

show abstract

“…In addition to microbes, exposure to diesel increased ETAR expression in the lungs of mice (45). In SSc, associations are present between the severity of interstitial lung disease (ILD) with the exposure to Benzol, which is another surrogate marker for traffic-induced air pollution (46).…”

Section: Abnormal High G Protein-coupled Receptor Antibodies and G Prmentioning

confidence: 99%

What Makes Antibodies Against G Protein-Coupled Receptors so Special? A Novel Concept to Understand Chronic Diseases

2020

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Expressions of G protein-coupled receptors (GPCR) on immune and tissue resident cells are the consequence of the cellular environment, which is highly variable. As discussed here, antibodies directed to GPCR (GPCR abs), their levels and correlations to other abs, serve as biomarkers for various diseases. They also could reflect the individual interplay between the environment and the immune system. Thus, GPCR abs could display pathogenic chronic conditions and could help to identify disease-related pathways. Moreover, by acting as ligands to their corresponding receptors, GPCR abs modulate autoimmune as well as non-autoimmune diseases. This article introduces GPCR abs as drivers for diseases by their capability to induce a specific signaling and by determining immune cell homeostasis. The identification of the individual GPCR ab function is challenging but might be pivotal in the comprehension of the aetiology of diseases. This, hopefully, will lead to the identification of novel therapeutic strategies. This article provides an overview about concepts and recent developments in research. Accordingly, GPCR abs could represent ideal candidates for precision medicine. Here, we introduce the term antibodiom to cover the network of abs with GPCR abs as prominent players.

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“…Animals were exposed in a whole body chamber to diesel exhaust particles for one hour, five times a week, for 60 days by a stationary diesel electrical generator (BD-2500 CFE; Branco, China) fitted via a simple connection on its exhaust tube that was divided into three compartments: an exhibition room, machine room and room in which the particles were generated. The exhibition room consisted of a bench with exposure chambers, a pressure-regulating valve and an apparatus that measured PM2.5, NOx, NO 2 and NO levels [20,21].…”

Section: Exposure To Pollutantsmentioning

confidence: 99%

Chronic exposure to diesel particles worsened emphysema and increased M2-like phenotype macrophages in a PPE-induced model

et al. 2020

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Chronic exposure to ambient levels of air pollution induces respiratory illness exacerbation by increasing inflammatory responses and apoptotic cells in pulmonary tissues. The ineffective phagocytosis of these apoptotic cells (efferocytosis) by macrophages has been considered an important factor in these pathological mechanisms. Depending on microenvironmental stimuli, macrophages can assume different phenotypes with different functional actions. M1 macrophages are recognized by their proinflammatory activity, whereas M2 macrophages play pivotal roles in responding to microorganisms and in efferocytosis to avoid the progression of inflammatory conditions. To verify how exposure to air pollutants interferes with macrophage polarization in emphysema development, we evaluated the different macrophage phenotypes in a PPE-induced model with the exposure to diesel exhaust particles. C57BL/6 mice received intranasal instillation of porcine pancreatic elastase (PPE) to induce emphysema, and the control groups received saline. Both groups were exposed to diesel exhaust particles or filtered air for 60 days according to the groups. We observed that both the diesel and PPE groups had an increase in alveolar enlargement, collagen and elastic fibers in the parenchyma and the number of macrophages, lymphocytes and epithelial cells in BAL, and these responses were exacerbated in animals that received PPE instillation prior to exposure to diesel exhaust particles. The same response pattern was found inCaspase-3 positive cell analysis, attesting to an increase in cell apoptosis, which is in agreement with the increase in M2 phenotype markers, measured by RT

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Acute exposure to diesel and sewage biodiesel exhaust causes pulmonary and systemic inflammation in mice

Cited by 40 publications

References 44 publications

The need for clean air: The way air pollution and climate change affect allergic rhinitis and asthma

The need for clean air: The way air pollution and climate change affect allergic rhinitis and asthma

What Makes Antibodies Against G Protein-Coupled Receptors so Special? A Novel Concept to Understand Chronic Diseases

Chronic exposure to diesel particles worsened emphysema and increased M2-like phenotype macrophages in a PPE-induced model

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