Acute exposure to air pollutants increase the risk of acute glaucoma

Abstract

Background Ambient air pollution is related to the onset and progression of ocular disease. However, the effect of air pollutants on the acute glaucoma remains unclear. Objective To investigate the effect of air pollutants on the incidence of acute glaucoma (acute angle closure glaucoma and glaucomatocyclitic crisis) among adults. Methods We conducted a time-stratified case-crossover study based on the data of glaucoma outpatients from January, 2015 to Dec, 2021 in Shanghai, China. A conditional logistic regression model combined with a polynomial distributed lag model was applied for the statistical analysis. Each case serves as its own referent by comparing exposures on the day of the outpatient visit to the exposures on the other 3–4 control days on the same week, month and year. To fully capture the delayed effect of air pollution, we used a maximum lag of 7 days in main model. Results A total of 14,385 acute glaucoma outpatients were included in this study. We found exposure to PM2.5, PM10, nitrogen dioxide (NO2) and carbon monoxide (CO) significantly increased the odds of outpatient visit for acute glaucoma. Wherein the odds of acute glaucoma related to PM2.5 and NO2 were higher and more sustained, with OR of 1.07 (95%CI: 1.03–1.11) and 1.12 (95% CI: 1.08–1.17) for an IQR increase over lag 0–3 days, than PM10 and CO over lag 0–1 days (OR:1.03; 95% CI: 1.01–1.05; OR: 1.04; 95% CI: 1.01–1.07). Conclusions This case-crossover study provided first-hand evidence that air pollutants, especially PM2.5 and NO2, significantly increased risk of acute glaucoma.

Ambient Air Pollution and Vision Disorder: A Systematic Review and Meta-Analysis

“…Considering the inclusion and exclusion standards, 50 studies were excluded, of which four were reviews, one was an animal study, three were non-English articles, and 42 did not meet the inclusion criteria ( Figure 1 ). Twelve studies [ 3 , 5 , 10 , 12 , 13 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ] evaluating the relationship between air pollutant exposure and the risk of vision disorder outcomes were included in this meta-analysis.…”

“…The diamond represents the summary results of multiple studies, where the dashed line perpendicular to the X-axis and passing through the center of the diamond represents the merged effect value, and the width of the diamond represents 95% CI of the merged results; 5. The area of gray squares represents weight, and the larger the weight, the larger the square area) [ 3 , 5 , 10 , 12 , 13 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ].…”

Chlorinated Polyfluoroalkyl Ether Sulfonic Acids (Cl-PFESAs) Are Associated with Eye Diseases in Humans and Eye Toxicity in Zebrafish

“…Cigarette smoking is considered to be an important environmental factor that increases the incidence of AMD and cataracts. , Particulate matter (PM 2.5 ) exposure increased the odds of myopia in children and elderly Chinese people . Air pollutant exposure increased the odds of visual impairment, , glaucoma, and presbyopia in the Chinese population. Biomass fuels were associated with increased odds of cataracts in Indian women …”