“…In several cases, serum CPK levels continued to rise despite conservative management that included aggressive fluid replacement; in every case, these dramatic post-treatment-initiation related increases (e.g., from 19,000 to 60,800 U/L3) in CPK occurred in a weight-lifter. 3,5,7,8 Categorizing patients into those under versus over age 40, eight of eleven (73%) younger patients ultimately had CPK levels over 50,000 U/L, versus just one of four (25%) over age forty; and the single person > 40 years old who had a CPK peak >50,000 was one whose rhabdomyolysis and consequent compartment syndrome were related to the drug cathinone; this patient's CPK peaked at 162,4956. Categorizing patients into athletes, post-operative patients, drug users, and the single case of direct trauma, both drug abusers had CPK peaks > 100,000 (mean = 256,000 U/L).…”