Acute exercise preferentially redeploys NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells. Part II: Impact of latent cytomegalovirus infection and catecholamine sensitivity

Bigley, Austin B.; Rezvani, Katayoun; Pistillo, Mira; Reed, Justin; Agha, Nadia H.; Kunz, Hawley; O’Connor, Daniel P.; Sekine, Takuya; Bollard, Catherine M.; Simpson, Richard J.

doi:10.1016/j.bbi.2014.12.027

Cited by 41 publications

(58 citation statements)

References 25 publications

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“…Differences in the mobilization of NK cells by exercise between CMV+ and CMV− have also been reported (Bigley et al. , ). Bigley et al.…”

Section: Discussionmentioning

confidence: 84%

“…Bigley et al. () demonstrated that the diminished responsiveness of NK cells to exercise in CMV+ is only observed following exercise intensities above lactate threshold. As CMV+ and CMV− exhibit similar increases in the catecholamines epinephrine and norepinephrine due to exercise, Bigley et al.…”

Section: Discussionmentioning

confidence: 99%

“…Additional data collected in this experimental protocol have been described elsewhere (Bigley et al. ; Kunz et al. ).…”

Section: Methodsmentioning

confidence: 99%

“…Interestingly, it has recently been shown that this differential effect of CMV infection on NK‐cell mobilization is only present at exercise above lactate threshold, but not below (Bigley et al. ). As the lactate threshold corresponds to the point at which the catecholamines epinephrine and norepinephrine increase exponentially during exercise (Podolin et al.…”

Section: Introductionmentioning

confidence: 99%

“…), Bigley et al. () explained the intensity‐dependent effect of CMV by demonstrating that β 2‐adrenergic receptors on NK cells in CMV+ are less sensitive to the rise in catecholamines. Whether the impact of CMV infection on T‐cell redeployment following exercise depends on exercise intensity remains to be determined.…”

Section: Introductionmentioning

confidence: 99%

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T‐cell redeployment and intracellular cytokine expression following exercise: effects of exercise intensity and cytomegalovirus infection

LaVoy

Hussain

Reed

et al. 2017

Physiological Reports

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The magnitude of lymphocytosis following exercise is directly related to exercise intensity. Infection with cytomegalovirus (CMV) also augments lymphocytosis after exercise. It is not known if the enhanced T‐cell response to exercise due to CMV depends on exercise intensity. Furthermore, exercise‐induced changes in T‐cell expression of type I and type II cytokines are thought to be intensity dependent, but direct comparisons are lacking. The aim of this experiment was to determine if CMV affects the exercise‐induced redistribution of T‐cell subsets at varying intensities, and determine the effect of exercise intensity on CD8+ T‐cell cytokine expression. Seventeen cyclists (nine CMV seropositive; CMV+) completed three 30 min cycling trials at −5, +5, and +15% of blood lactate threshold (LT). T‐cell subsets in blood and intracellular expression of type I (IL‐2, interferon(IFN)‐γ) and type II (IL‐4, IL‐10) cytokines by CD8+ T cells pre, post, and 1‐h post‐exercise were assessed by flow cytometry. Independently of CMV, T‐cell subset redistribution was greater after +15%LT compared to −5%LT (P < 0.05). Independently of intensity, CMV− mobilized more low‐ (CD27+ CD28+) and medium‐ (CD27+ CD28−) differentiated T cells than CMV+, whereas CMV+ mobilized more high (CD27− CD28−) differentiated T cells. The numbers of IL‐2+, IFN‐γ+, IL‐4+, and IL‐10+ CD8+ T cells increased after exercise above LT. Only type I cytokine expression was influenced by exercise intensity (P < 0.05). In conclusion, T‐cell redeployment by exercise is directly related to exercise intensity, as are changes in the number of CD8+ T‐cells expressing type I cytokines. Although CMV+ mobilized more high‐differentiated T cells than CMV−, this occurred at all intensities. Therefore, the augmenting effect of CMV on T‐cell mobilization is independent of exercise intensity.

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“…Differences in the mobilization of NK cells by exercise between CMV+ and CMV− have also been reported (Bigley et al. , ). Bigley et al.…”

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

“…Additional data collected in this experimental protocol have been described elsewhere (Bigley et al. ; Kunz et al. ).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning