Acute exercise increases circulating IGF-1 in Alzheimer’s disease patients, but not in older adults without dementia

Stein, Angélica Miki; Silva, Thays Martins Vital da; Coelho, Flávia Gomes de Melo; Rueda, André Veloso Lima; Camarini, Rosana; Galduróz, Ruth Ferreira

doi:10.1016/j.bbr.2020.112903

Cited by 14 publications

(13 citation statements)

References 59 publications

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“…This can be further explained by several physiological mechanisms (Umegaki et al, 2021). Physical exercise or multicomponent exercise programs can lead to the release of neurotrophic factors, such as a brainderived neurotrophic factor (Rehfeld et al, 2018;Ruiz-González et al, 2021) and insulin growth factor 1 (Kang et al, 2020;Stein et al, 2021), which can cross the blood-brain barrier to induce the synaptic plasticity and neurogenesis that to improve cognition. Moreover, the increase in the release of a brain-derived neurotrophic factor after physical activity can positively influence depressive symptoms (Penseyres and Martin, 2018).…”

Section: Explanations For the Beneficial Effects Of Physical Exercise...mentioning

confidence: 99%

Effects of Chronic Physical Exercise or Multicomponent Exercise Programs on the Mental Health and Cognition of Older Adults Living in a Nursing Home: A Systematic Review of Studies From the Past 10 Years

et al. 2022

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Some nursing homes for the elderly provide holistic care that integrates several interventions, including physical exercise. The aim of this systematic review is to summarize the effects of physical exercise or multicomponent exercise programs on the mental health (wellbeing, anxiety and depression) and cognitive functions of older adults with/without dementia who live in a nursing home and do/do not require wheelchair assistance. To this end, PubMed, PsycInfo and Web of Science are using to identify clinical trials and randomized controlled studies conducted during the period January 2011 to December 2021 to examine the progression of research in this field over the past ten years. In total, 2597 articles are identifying and 21 are including in the systematic review. After selecting articles according to the PRISMA standards, the data extraction and methodological quality assessment of the eligible studies are performing individually by two reviewers and then pooled together. The synthesis of the studies shows that physical exercise or multicomponent exercise programs have a beneficial effect on mental health and cognitive functions. However, this effect is more common among older adults without dementia, compared to their counterparts who have dementia or use wheelchairs. The explanatory mechanisms, lack of benefits from physical exercise and the need to standardize methods are discussing in this regard. Finally, future studies must examine the effects of an innovative and adaptive physical activity program on the mental health and cognitive functions of older adults living in nursing homes.

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Section: Explanations For the Beneficial Effects Of Physical Exercise...mentioning

confidence: 99%

Effects of Chronic Physical Exercise or Multicomponent Exercise Programs on the Mental Health and Cognition of Older Adults Living in a Nursing Home: A Systematic Review of Studies From the Past 10 Years

et al. 2022

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“…A cross-sectional study by Duron et al [101] showed a significant association between low IGF-I serum levels and neurodegenerative process of AD in men, but not in women (218 men, 476 women; 78.6 ± 6.7 y). Parallel to this, evidence suggests that IGF-1 may have a role in beta-amyloid clearance and reducing hyperphosphorylation tau in AD [102].…”

Section: Insulin-like Growth Factor-1 (Igf-1)mentioning

confidence: 89%

“…However, no difference was found between the two types of exercise. A recent study investigated circulating IGF-1 levels in AD patients (n = 34) and older adults (n = 40) without dementia after acute exercise (Balke-Ware test: incremental test on a treadmill), [102]. After the intervention, higher levels of IGF-1 were observed in AD patients.…”

Section: The Effect Of Exercise On the Irisin Pathway And Related Dep...mentioning

confidence: 99%

The Potential Role of Exercise-Induced Neurotrophic Factors for Mental Health

Zühtü Birinci

2023

Mental Health - Preventive Strategies

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Today, there is a great scientific interest in understanding the mechanisms of mental disorders. Three lifestyle factors may play an essential role in protecting brain health: a socially integrated network, cognitive leisure activity, and regular exercise. It is widely accepted that exercise is a non-pharmacological, low-cost, easily accessible, and non-adverse promising method to delay brain deterioration in aging, and it was also suggested that exercise improves brain health across the lifespan. Despite the clear relationship between exercise and mental health, our knowledge of the cellular and molecular mechanisms that trigger such benefits is still limited. Pioneering studies showed that various peripheral factors (brain-derived neurotrophic factors, insulin-like growth factor-1, irisin, etc.) are released into the bloodstream via exercise. Moreover, there is much evidence that enhancement of neurogenesis, angiogenesis, and synaptogenesis caused by exercise-induced neurotrophins and growth factors, such as the BDNF, IGF-1, irisin, and VEGF, etc., has an essential role in the positive changes of mental health. Nevertheless, there is currently insufficient evidence to draw firm conclusions regarding the relationship between optimum exercise regime and maximize mental health via modulation of neurotrophic factors.

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“…The upstream IGF-1 signaling pathway also induces BDNF expression ( Yan et al, 2011 ). Interventional trials demonstrated that aerobic exercise increased plasma IGF-1 in older adults ( Kang et al, 2020 ), including those with MCI ( Baker et al, 2010 ) and AD ( Stein et al, 2021 ). A systematic review concluded that resistance training also increased IGF-1 levels in participants, including older adults ( Jiang et al, 2020 ).…”

Section: Physiological Mechanismsmentioning

confidence: 99%

Active Life for Brain Health: A Narrative Review of the Mechanism Underlying the Protective Effects of Physical Activity on the Brain

Umegaki

Sakurai

Arai

2021

Front. Aging Neurosci.

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A growing body of evidence clearly indicates the beneficial effects of physical activity (PA) on cognition. The importance of PA is now being reevaluated due to the increase in sedentary behavior in older adults during the COVID-19 pandemic. Although many studies in humans have revealed that PA helps to preserve brain health, the underlying mechanisms have not yet been fully elucidated. In this review, which mainly focuses on studies in humans, we comprehensively summarize the mechanisms underlying the beneficial effects of PA or exercise on brain health, particularly cognition. The most intensively studied mechanisms of the beneficial effects of PA involve an increase in brain-derived neurotrophic factor (BDNF) and preservation of brain volume, especially that of the hippocampus. Nonetheless, the mutual associations between these two factors remain unclear. For example, although BDNF presumably affects brain volume by inhibiting neuronal death and/or increasing neurogenesis, human data on this issue are scarce. It also remains to be determined whether PA modulates amyloid and tau metabolism. However, recent advances in blood-based biomarkers are expected to help elucidate the beneficial effects of PA on the brain. Clinical data suggest that PA functionally modulates cognition independently of neurodegeneration, and the mechanisms involved include modulation of functional connectivity, neuronal compensation, neuronal resource allocation, and neuronal efficiency. However, these mechanisms are as yet not fully understood. A clear understanding of the mechanisms involved could help motivate inactive persons to change their behavior. More accumulation of evidence in this field is awaited.

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Acute exercise increases circulating IGF-1 in Alzheimer’s disease patients, but not in older adults without dementia

Cited by 14 publications

References 59 publications

Effects of Chronic Physical Exercise or Multicomponent Exercise Programs on the Mental Health and Cognition of Older Adults Living in a Nursing Home: A Systematic Review of Studies From the Past 10 Years

Effects of Chronic Physical Exercise or Multicomponent Exercise Programs on the Mental Health and Cognition of Older Adults Living in a Nursing Home: A Systematic Review of Studies From the Past 10 Years

The Potential Role of Exercise-Induced Neurotrophic Factors for Mental Health

Active Life for Brain Health: A Narrative Review of the Mechanism Underlying the Protective Effects of Physical Activity on the Brain

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