Acute exacerbation of interstitial pneumonia associated with collagen vascular diseases

Suda, Takafumi; Kaida, Yusuke; Nakamura, Yutaro; Fujisawa, Tomoyuki; Imokawa, Shiro; Hashizume, Hideo; Naito, Tateaki; Dai, Huaping; Takehara, Yasuo; Inui, Naoki; Nakamura, Hirotoshi; Colby, Thomas V.; Chida, Kingo

doi:10.1016/j.rmed.2008.12.019

Cited by 200 publications

(217 citation statements)

References 26 publications

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“…Suda et al (2009) suggested that advanced age was a risk factor for acute exacerbation in connective tissue disease-related ILD, but the age of onset was not an associated factor in our study (Table 4). About 10%-20% of patients with SSc had overlapping features with other rheumatic diseases (Kowal-Bielecka et al 2009;Pakozdi et al 2011).…”

Section: Discussionmentioning

confidence: 54%

“…Suda et al (2009) reported that none out of 13 patients showed AE-ILD during median follow-up of 6 years; however, Ando et al (2013) showed that 3 out of 71 patients (4.2%) died of AE-ILD during 9.8 years of follow-up. Our study result showing that 6 out of 139 patients (4.3%) died of AE-ILD is consistent with the latter (Ando et al 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, AE-ILD occurred at a frequency of 9.4% (13/139) in our study. Previous papers showed that the 1-year frequency of acute exacerbation was 1.25%-3.3% and a lifetime incidence 7.2% in patients with connective tissue disease (Park et al 2007;Suda et al 2009). …”

Section: Discussionmentioning

confidence: 99%

“…When limited to Japanese patients with SSc, there are three case series concerning AE-ILD (Suda et al 2009;Tachikawa et al 2012;Ando et al 2013). Suda et al (2009) reported that none out of 13 patients showed AE-ILD during median follow-up of 6 years; however, Ando et al (2013) showed that 3 out of 71 patients (4.2%) died of AE-ILD during 9.8 years of follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…Cyclophosphamide was demonstrated to stabilize lung function in a randomized controlled trial, but its beneficial effect disappeared at 24 months (Tashkin et al 2006;Tashkin et al 2007). Moreover, acute exacerbation of ILD (AE-ILD) occurs at a 1-year frequency of 1.25%-3.3% and at a lifetime incidence of 7.2%, with a high mortality rate in patients with connective tissue disease (Park et al 2007;Suda et al 2009). Given the chronic nature of the disease, it has been considered that AE-ILD is not common in patients with SSc (Fan et al 2014;Cappelli et al 2015), but recent papers suggest that AE-ILD may occur even in patients with SSc (Park et al 2007;Bussone and Mouthon 2011;Tachikawa et al 2012;Ando et al 2013;Yasuoka 2016).…”

Section: Introductionmentioning

confidence: 99%

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High Prevalence of Acute Exacerbation of Interstitial Lung Disease in Japanese Patients with Systemic Sclerosis

Tomiyama

Watanabe

Ishii

et al. 2016

Tohoku J. Exp. Med.

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Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by extensive fibrosis and autoantibodies. Its clinical manifestations are diverse and include Raynaud's phenomenon, gastrointestinal dysmotility, interstitial lung disease (ILD), pulmonary hypertension, and renal crisis. Among these, ILD is the primary cause of SSc-related death. It has been considered that acute exacerbation of ILD (AE-ILD) is not common in patients with SSc; however, little is known about the prevalence of AE-ILD in Japanese patients with SSc. In this study, we aimed to clarify the prevalence, clinical characteristics, and prognosis of patients with SSc who developed AE-ILD and to identify predictive factors for AE-ILD in our Japanese cohorts. Clinical data of patients who visited our department from 1990 to 2014 and fulfilled the 2013 classification criteria for SSc were retrospectively reviewed. A total of 139 patients were enrolled. The mean age of onset was 49.1 years, and 113 (81.3%) patients were female; 116 (83.5%) had limited cutaneous involvement, and the overall 10-year survival rate was 92.0%. Among 66 (47.5%) patients with ILD, 13 (9.4%) developed AE-ILD. Patients with AE-ILD had a significantly higher incidence of overlap with polymyositis (PM) or dermatomyositis (DM) and lower prevalence of anticentromere antibodies with higher mortality rate compared with those without AE-ILD. Multivariate Cox regression analysis identified that an overlap with PM or DM was the most significant predictive factor for AE-ILD. Our study results suggest that Japanese patients with SSc, particularly patients overlapped with PM or DM, have a high risk of AE-ILD.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High Prevalence of Acute Exacerbation of Interstitial Lung Disease in Japanese Patients with Systemic Sclerosis

Tomiyama

Watanabe

Ishii

et al. 2016

Tohoku J. Exp. Med.

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Recent‐onset systemic lupus erythematosus complicated by acute respiratory failure

Demoruelle

Kahr

Verilhac

et al. 2013

Arthritis Care & Research

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Detection of interstitial pneumonia with autoimmune features and idiopathic pulmonary fibrosis are enhanced by involvement of matrix metalloproteinases levels and clinical diagnosis

Liu

Xue

Zhang

et al. 2022

Clinical Laboratory Analysis

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Background: Higher detection of interstitial pneumonia with autoimmune features (IPAF), idiopathic pulmonary brosis (IPF) has signi cant diagnostic and therapeutic implications. Some MMPs have been reliable diagnostic biomarkers in IPAF and IPF in previous studies, yet relevant reliability remains to be recognized. Material and Methods: 36 ILD patients, including 31 IPAF patients (Mean ± SD, 50.20 ± 5.10 years; 16 (51.6%) females) and 5 IPF patients (Mean ± SD, 61.20 ± 6.73 years; 1 (20.0%) females) were retrospectively enrolled. Serial serum samples were collected from corresponding patients between January 2019 and December 2020. Notably, Serum MMPs levels were measured by U-PLEX Biomarker Group 1(Human) Multiplex Assays (MSD, USA).Results: A combination of MMPs, combinatorial biomarkers and was strongly associated with the above clinical subjects (AUC, 0.597 for Stability vs. Improvement and 0.756 for Stability vs. Exacerbation).Importantly, the AUC of MMP-12 reaches 0.730 (P<0.05, Stability AUC vs. Improvement AUC) while MMP-13 reaches 0.741 (P<0.05, Stability AUC vs. Exacerbation AUC) showed better academic performance than other MMPs in two comparisons.Conclusions: Clinical risk factors and MMPs are strongly associated with either strati cation of the degree of disease of progression of IPAF or in two IPAF and IPF independent cohorts. To our knowledge, this is the rst to illustrate that MMP-12 and MMP-13 may be expected to become typical promising biomarkers in Improvement -IPAF and Exacerbation -IPAF, respectively.

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Acute exacerbation of interstitial pneumonia associated with collagen vascular diseases

Abstract: These data suggest that AE can occur in CVD-IP, and this condition is closely similar to that of IPF with poor prognosis. AE is most common in RA, and associated with higher ages.

Cited by 200 publications

References 26 publications

High Prevalence of Acute Exacerbation of Interstitial Lung Disease in Japanese Patients with Systemic Sclerosis

High Prevalence of Acute Exacerbation of Interstitial Lung Disease in Japanese Patients with Systemic Sclerosis

Recent‐onset systemic lupus erythematosus complicated by acute respiratory failure

Detection of interstitial pneumonia with autoimmune features and idiopathic pulmonary fibrosis are enhanced by involvement of matrix metalloproteinases levels and clinical diagnosis

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