“…No change (Faraco et al, 2015b) Increase (slight) (Faraco et al, 2015b) SvO2 Increase (Faraco et al, 2015b) Increase (Faraco et al, 2015b) * Assumed (See section 4.3) † Contributing effects of hypocapnia for non-isocapnic stimuli Hct typically ranges between 36-54% (Billett, 1990), with natural fluctuations arising as a function of age, (Adeli et al, 2015;Daniel, 1973) and potentially race (Beutler and West, 2017;Cheng et al, 2004). The need for individualised knowledge of Hct becomes critical in anaemia, with significant reductions observed in a wide range of pathology (Babitt and Lin, 2012;Goodnough et al, 2003;Muncie and Campbell, 2009;Rees et al, 2010;van Iperen et al, 2001), secondary to therapy (Groopman and Itri, 1999;Ludwig et al, 2004;Rodgers et al, 2012), and in response to poor nutrition (Baker and Demaeyer, 1979 (Joseph et al, 2016;Li et al, 2017). Furthermore, Hct is known to be reduced in microvasculature in comparison to larger vessels.…”