2021
DOI: 10.3390/ijms23010290
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Acute Ethanol Exposure during Synaptogenesis Rapidly Alters Medium Spiny Neuron Morphology and Synaptic Protein Expression in the Dorsal Striatum

Abstract: Fetal alcohol spectrum disorders are caused by the disruption of normal brain development in utero. The severity and range of symptoms is dictated by both the dosage and timing of ethanol administration, and the resulting developmental processes that are impacted. In order to investigate the effects of an acute, high-dose intoxication event on the development of medium spiny neurons (MSNs) in the striatum, mice were injected with ethanol on P6, and neuronal morphology was assessed after 24 h, or at 1 month or … Show more

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Cited by 4 publications
(3 citation statements)
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References 52 publications
(66 reference statements)
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“…This is not surprising given that the prelimbic cortex is a region shown to play a role in alcohol-drinking reinforcement ( Engleman et al, 2020 ). These data are consistent with other brain areas (basal ganglia) where reductions in spine densities observed immediately after exposure seemed to reverse by 1 month of age ( Clabough et al, 2022 ). It is possible that alterations occurred in synaptogenesis and/or pruning earlier in the exposure period and recovered by weaning when the first measures were taken.…”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…This is not surprising given that the prelimbic cortex is a region shown to play a role in alcohol-drinking reinforcement ( Engleman et al, 2020 ). These data are consistent with other brain areas (basal ganglia) where reductions in spine densities observed immediately after exposure seemed to reverse by 1 month of age ( Clabough et al, 2022 ). It is possible that alterations occurred in synaptogenesis and/or pruning earlier in the exposure period and recovered by weaning when the first measures were taken.…”
Section: Discussionsupporting
confidence: 90%
“…In early alcohol exposure models, acute exposures led to increased dendritic pruning in the prefrontal cortex, resulting in significant synapse loss (Socodato et al, 2020). Also, acute ethanol exposure during synaptogenesis (from P5 to P7) led to drastically decreased spine densities in the caudate/putamen, however, these densities recovered to normal levels by around P30 (Clabough et al, 2022).…”
Section: Lee and Dendritic Spine Densities In Frontal Cortexmentioning
confidence: 99%
“…Next, 6–8 MSNs were selected for each hemisphere, and 3 dendrites were selected per MSN for accuracy. The following criteria were used to select MSNs randomly: well‐impregnated neurons; clearly visible branches or other precipitates not obscured by other neurons; absence of visibly broken processes on the neuron; MSN visually resembled a typical medium spiny neuron (Clabough et al., 2021).…”
Section: Methodsmentioning
confidence: 99%