Acute Epigallocatechin-3-Gallate Supplementation Alters Postprandial Lipids after a Fast-Food Meal in Healthy Young Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

Abstract

A high-fat fast-food meal negatively impacts postprandial metabolism even in healthy young people. In experimental studies, epigallocatechin-3-gallate (EGCG), a bioactive compound present in green tea, has been described as a potent natural inhibitor of fatty acid synthase. Thus, we sought to evaluate the effects of acute EGCG supplementation on postprandial lipid profile, glucose, and insulin levels following a high-fat fast-food meal. Fourteen healthy young women 21 ± 1 years and body mass index 21.4 ± 0.41 kg/m2 were enrolled in a randomized, double-blind, placebo-controlled crossover study. Participants ingested capsules containing 800 mg EGCG or placebo immediately before a typical fast-food meal rich in saturated fatty acids. Blood samples were collected at baseline and then at 90 and 120 min after the meal. The EGCG treatment attenuated postprandial triglycerides (p = 0.029) and decreased high-density lipoprotein cholesterol (HDL-c) (p = 0.016) at 120 min. No treatment × time interaction was found for total cholesterol, low-density lipoprotein (LDL-c), and glucose or insulin levels. The incremental area under the curve (iAUC) for glucose was decreased by EGCG treatment (p < 0.05). No difference was observed in the iAUC for triglycerides and HDL-c. In healthy young women, acute EGCG supplementation attenuated postprandial triglycerides and glucose but negatively impacted HDL-c following a fast-food meal.

The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline

“…A significant number of clinical trials have been conducted on the EGCG polyphenolic flavonoid component of green tea. An examination of a selection of these trials [ 265 , 276 , 277 , 278 , 279 , 280 , 281 , 282 , 283 , 284 , 285 ] amply demonstrate the diverse biological properties of EGCG and its potential therapeutic applications. EGCG can potentially improve cognition in children with Down syndrome [ 276 ].…”

“…EGCG supplementation improves blood pressure, lipid profiles, plasma atherogenic index, and oxidative status in type 2 diabetes [ 283 ] when used in a controlled clinical trial on subjects receiving a high fat diet improved lipid profiles. EGCG has been described as a potent natural inhibitor of fatty acid synthase [ 284 ]. EGCG shows promise in an animal model of AD in the regulation of α-, β-, γ-secretase activity, inhibiting tau phosphorylation, has antioxidative, anti-inflammatory, antiapoptotic activity, and inhibits AChE activity, all contributing to EGCG’s neuroprotective properties [ 265 ].…”

Immunomodulatory Role of Plants and Their Constituents on the Management of Metabolic Disorders: An Evidence-Based Review

“…Among the thirty-six eligible studies, ten studies enrolled patients with either T2DM or prediabetes, 13 , 27–34 , 49 seven studies enrolled overweight or obese subjects, 14–16 , 36 , 42 , 45 , 47 three studies enrolled patients with metabolic syndrome or their risk factors, 19 , 20 , 50 three studies evaluated patients dyslipidemia, 12 , 21 , 35 two studies enrolled patients with hepatic steatosis or non-alcoholic fatty liver disease (NAFLD), 39 , 41 other studies enrolled patients with CVD or CVD risk factors, 37 , 40 diabetic nephropathy, 38 and healthy volunteers. 1 , 22 , 25 , 26 , 43 , 44 , 46 , 48 …”

“… 61 In a clinical study conducted by Morais et al, it was elucidated that EGCG’s role in mitigating insulin resistance and liver TG concentrations is linked to diminished lipid uptake and a decrease in inflammatory cytokine levels. 46 …”

“…Conversely, the slope related to ischemic-reperfusion remained unaffected by the treatment (P = 0.83) Valderas-Martinez et al, 2016 25 CVD RCT, open, crossover, and prospective 40 Non-smokers not receiving medication or vitamin supplements Healthy Tomato sauce with olive oil Control 14 days Tomato sauce augmented with refined olive oil may modulate the lipid profile and influence soluble inflammatory biomarkers associated with the initiation and progression of atherosclerosis. de Morais Junior et al, 2020 46 Hypertriglyceridemia RCT, double-blind, placebo-controlled, and crossover 14 Young women Aged 18 to 25 years old Healthy EGCG N/a Acute (90 and 120 min after the meal) EGCG moderated postprandial triglyceride (TG) and glucose levels; however, it adversely influenced HDL-C subsequent to the consumption of a high-fat fast-food meal Lopez et al, 2017 47 Obesity RCT, double-blind, placebo-controlled, parallel-groups design, and single-center 105 Overweight; men or women Aged ≥35 to ≤70 years old Normally active or judged to be in good health on the basis of medical history and physical examination T. chebula fruit N/a 84 days (14 weeks period) Relative to the placebo, the treatment notably ameliorated various parameters: mKOOS global scores (P = 0.023), both total and physical function dimensions of mWOMA, VAS indices for Knee Discomfort (P = 0.001), VAS evaluations for systemic joint functionality (P < 0.029), VAS measurements reflecting reduced knee joint soreness (P = 0.022), AyuFlex2 (P = 0.043), the distance traversed during the 6-minute walk assessment (P = 0.047), and the post-walk VAS discomfort scores (P = 0.026). Additionally, there was a suggestive decline in COMP levels, although this did not reach statistical signif...…”