Acute eosinophilic leukemia with a translocation (10p +; 11q−)

Broustet, A; Bernard, P; Dachary, Dominique; David, B.; Marit, Gérald; Lacombe, Francis; Issanchou, A.M.

doi:10.1016/0165-4608(86)90213-x

Cited by 25 publications

(9 citation statements)

References 31 publications

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“…Furthermore, isochromo some 17 [9], translocation (8;22) [10] and translocation (10;11) [11] have also been reported in EoL. Although it has been postulated that a specific region of these chromosomes be responsible for the development of the eosinophilia, in the present case, no gross abnor mality of these chromosomes was observed and the Ph1 chromosome was absent.…”

Section: Discussioncontrasting

confidence: 41%

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Acute Eosinophilic Leukemia in a Patient with Preexistent Myelodysplastic Syndrome

Murakawa

Shibuya²,

Taniguchi³

et al. 1991

Acta Haematol

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A case of acute eosinophilic leukemia (EoL) that occurred in a patient with preexistent myelodysplastic syndrome is reported. The patient was initially diagnosed as having refractory anemia (RA) on the basis of pancytopenia with dysplasia and chromosomal abnormalities. Two years later, he was readmitted because of progression of pancytopenia, and bone marrow and peripheral blood showed immature dysplastic eosinophils. Clonal assay of peripheral blood mononuclear cells revealed autonomous growth of colony-forming unit eosinophils. Cytotoxic chemotherapy did not induce remission, and extensive myelofibrosis developed. Cytogenetic analysis in the RA state showed +1p^- and -7 whereas complicated abnormalities including +1p^-, 3q^- and 7p^- dominated in the EoL state.

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Section: Discussioncontrasting

confidence: 41%

“…Furthermore, other chromosomal abnormalities have also been reported in eosinophilic leukemias [9][10][11]18], and it has been noted that these abnormalities might be responsible for the development of neoplastic eosinophilia.…”

Section: Introductionmentioning

confidence: 99%

Acute Eosinophilic Leukemia in a Patient with Preexistent Myelodysplastic Syndrome

Murakawa

Shibuya²,

Taniguchi³

et al. 1991

Acta Haematol

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“…It has also been reported in one case of acute myelocytic leukemia (FAB class M1) (Raimondi et al, 1989) and two cases of eosinophilic leukemia (Broustet et al, 1986;Fischkoff et al, 1988). It is interesting to note that in cases of AML with 10~13-14 involvement, the translocation partner is usually chromosome 11, most commonly at llq21.…”

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confidence: 90%

Characterization of a t(I0; II) (pI3‐I4; qI4‐2I) in the monoblastic cell line U937

Shipley

Williams²,

O'Byrne

et al. 1995

Genes Chromosomes & Cancer

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Previous analysis of the monoblastic cell line U937 has shown that several sublines contain a rearranged chromosome arm 11q. In order to determine the true nature of the rearrangement, fluorescence in situ hybridization (FISH) was carried out with various combinations of single copy anonymous markers, clones containing genes, a chromosome 10 paint, and an 11 centromere specific sequence. The rearrangement was deduced to be a reciprocal translocation between chromosomes 10 and 11 described as t(10;11)(p13-14;q14-21). The breakpoint on chromosome 11 is telomeric to the INT2 gene and the pHS11 probe at 11q13, and centromeric to the marker D11S36 localized to 11q14.3-q22.1 and the MLL gene at 11q23. Similar translocations have been reported in various acute leukemias, principally of the monocytic lineage, and also in T-cell precursor acute lymphocytic leukemias. Further characterization of the genetic rearrangements in U937 may lead to the isolation of genes important in leukemogenesis and provide an in vitro system for their study.

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“…Also in a case with refractory anaemia, markedly increased eosinophils were found, but the aberrant karyotype was not found in the eosinophils (Perez-Losada et al, 1994). In HES, several patients with different chromosome abnormalities have been decribed, which suggests a malignant monoclonal myeloproliferative disorder in these cases (Malbrain et al, 1996;Broustet et al, 1986;Mori et al, 1986;Fischkoff et al, 1988;Yoo et al, 1988;Needleman et al, 1990;Ribeiro et al, 1993;Sato et al, 1994). However, these cases lacked direct evidence that the eosinophils were part of the malignant clone.…”

mentioning

confidence: 99%

Chronic eosinophilic leukaemia (CEL): a distinct myeloproliferative disease

Weide¹,

Rieder

Mehraein

et al. 1997

Br J Haematol

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Chronic eosinophilic leukaemia has not yet been clearly defined, mainly due to the fact that it has not been conclusively shown as a monoclonal disease which should be separated from chronic myelogenous leukaemia, acute myelogenous leukaemia with eosinophilia (AML, FAB M4Eo), and the idiopathic hypereosinophilic syndrome. We report a patient with a white blood cell count of 17.6 × 109/l with 74% eosinophils, normal platelet count and haemoglobin. No blasts were seen in the peripheral blood and the percentage of blasts in the bone marrow was <3%. A diagnosis of chronic eosinophilic leukaemia was made. Chromosome analysis of a bone marrow aspirate disclosed a trisomy 15 together with loss of the Y chromosome. Moreover, FISH analysis on May‐Grünwald‐Giemsa‐stained peripheral blood smears demonstrated trisomy 15 in the eosinophils. 3 months after initial diagnosis the patient went into blast crisis and died. The blast cells exhibited trisomy 15 and loss of the Y chromosome in a complex, aberrant karyotype. In conclusion, the case shows that chronic eosinophilic leukaemia is a monoclonal, myeloproliferative disease with eosinophils as part of the malignant clone. Clinically, chronic eosinophilic leukaemia can be separated into a chronic phase and a blast crisis.

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Acute eosinophilic leukemia with a translocation (10p +; 11q−)

Cited by 25 publications

References 31 publications

Acute Eosinophilic Leukemia in a Patient with Preexistent Myelodysplastic Syndrome

Acute Eosinophilic Leukemia in a Patient with Preexistent Myelodysplastic Syndrome

Characterization of a t(I0; II) (pI3‐I4; qI4‐2I) in the monoblastic cell line U937

Chronic eosinophilic leukaemia (CEL): a distinct myeloproliferative disease

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