Acute endurance exercise increases plasma membrane fatty acid transport proteins in rat and human skeletal muscle

Bradley, Nicolette S.; Snook, Laelie A.; Jain, Swati; Heigenhauser, George J. F.; Bonen, Arend; Spriet, Lawrence L.

doi:10.1152/ajpendo.00254.2011

Cited by 34 publications

(41 citation statements)

References 32 publications

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“…Long chain fatty acid transport into skeletal muscle is a highly regulated process involving several LCFA transport proteins [18, 34–37]. Some of these transport proteins have also been shown to translocate to the plasma membrane during moderate exercise, acutely increasing the ability of skeletal muscle to transport FFAs into the cell [34, 36].…”

Section: The Regulation Of Fat Metabolism: a New Eramentioning

confidence: 99%

New Insights into the Interaction of Carbohydrate and Fat Metabolism During Exercise

2014

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Fat and carbohydrate are important fuels for aerobic exercise and there can be reciprocal shifts in the proportions of carbohydrate and fat that are oxidized. The interaction between carbohydrate and fatty acid oxidation is dependent on the intracellular and extracellular metabolic environments. The availability of substrate, both from inside and outside of the muscle, and exercise intensity and duration will affect these environments. The ability of increasing fat provision to downregulate carbohydrate metabolism in the heart, diaphragm and peripheral skeletal muscle has been well studied. However, the regulation of fat metabolism in human skeletal muscle during exercise in the face of increasing carbohydrate availability and exercise intensity has not been well studied until recently. Research in the past 10 years has demonstrated that the regulation of fat metabolism is complex and involves many sites of control, including the transport of fat into the muscle cell, the binding and transport of fat in the cytoplasm, the regulation of intramuscular triacylglycerol synthesis and breakdown, and the transport of fat into the mitochondria. The discovery of proteins that assist in transporting fat across the plasma and mitochondrial membranes, the ability of these proteins to translocate to the membranes during exercise, and the new roles of adipose triglyceride lipase and hormone-sensitive lipase in regulating skeletal muscle lipolysis are examples of recent discoveries. This information has led to the proposal of mechanisms to explain the downregulation of fat metabolism that occurs in the face of increasing carbohydrate availability and when moving from moderate to intense aerobic exercise.

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Section: The Regulation Of Fat Metabolism: a New Eramentioning

confidence: 99%

New Insights into the Interaction of Carbohydrate and Fat Metabolism During Exercise

2014

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“…23 FABP-PM protein is consistently higher in skeletal muscle from trained humans. 17 Exerciseinduced alterations in FABP-PM regulation in humans may also be related to exercise intensity as moderate-intensity exercise does not alter protein expression, 21,22 whereas high-intensity exercise increases protein content. 23,24 While evidence indicates exercise training generally induces expression of these transporters, it is important to note that these changes are often subtle and are not consistently reported.…”

Section: Fatty Acid Transportersmentioning

confidence: 99%

Exercise and Regulation of Lipid Metabolism

Noland

2015

Progress in Molecular Biology and Translational Science

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“…Both training protocols in the present study induced upregulation of FAT/CD36, but not FABP pm , protein levels and both protocols produced FAT/CD36 increases of similar magnitude (46% and 43% increases for cold and exercise training, respectively). Exercise training generally increases both FAT/ CD36 and FABP pm protein levels and sarcolemmal fatty acid transport rates in mammals (Bonen et al, 1999;Bradley et al, 2012). Furthermore, FAT/CD36 knock-out mice also had lower myocyte fatty acid uptake during shivering under cold stress (Putri et al, 2015).…”

Section: Trans-sarcolemmal Lipid Transportmentioning

confidence: 99%

Acute cold and exercise training upregulate similar aspects of fatty acid transport and catabolism in house sparrows, Passer domesticus

Zhang

Carter

Eyster

et al. 2015

Journal of Experimental Biology

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Summit maximum thermoregulatory metabolic rate (M sum ) and maximum exercise metabolic rate (MMR) both increase in response to acute cold or exercise training in birds. Because lipids are the main fuel supporting both thermogenesis and exercise in birds, adjustments to lipid transport and catabolic capacities may support elevated energy demands from cold and exercise training. To examine a potential mechanistic role for lipid transport and catabolism in organismal cross-training effects (exercise effects on both exercise and thermogenesis, and vice versa), we measured enzyme activities and mRNA and protein expression in pectoralis muscle for several key steps of lipid transport and catabolism pathways in house sparrows (Passer domesticus) during acute exercise and cold training. Both training protocols elevated pectoralis protein levels of fatty acid translocase (FAT/CD36), cytosolic fatty acid-binding protein, and citrate synthase (CS) activity. However, mRNA expression of FAT/CD36 and both mRNA and protein expression of plasma membrane fatty acid-binding protein did not change for either training group. CS activities in supracoracoideus, leg and heart, and carnitine palmitoyl transferase (CPT) and β-hydroxyacyl CoA-dehydrogenase activities in all muscles did not vary significantly with either training protocol. Both M sum and MMR were significantly positively correlated with CPT and CS activities. These data suggest that up-regulation of trans-sarcolemmal and intramyocyte lipid transport capacities and cellular metabolic intensities, along with previously documented increases in body and pectoralis muscle masses and pectoralis myostatin (a muscle growth inhibitor) levels, are common mechanisms underlying the training effects of both exercise and shivering in birds.

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Acute endurance exercise increases plasma membrane fatty acid transport proteins in rat and human skeletal muscle

Cited by 34 publications

References 32 publications

New Insights into the Interaction of Carbohydrate and Fat Metabolism During Exercise

New Insights into the Interaction of Carbohydrate and Fat Metabolism During Exercise

Exercise and Regulation of Lipid Metabolism

Acute cold and exercise training upregulate similar aspects of fatty acid transport and catabolism in house sparrows, Passer domesticus

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