Acute encephalopathy with biphasic seizures and late reduced diffusion in a Spanish girl

García‐Boyano, Miguel; Caballero-Caballero, José Manuel; Alguacil-Guillén, Marina; Baquero-Artigao, Fernando

doi:10.1016/j.braindev.2019.12.004

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…It seems that HHV-7 infection is linked to severe and uncommon neurologic entities. 14,15 In our case, at the end of treatment with ganciclovir-a nucleoside analog-, the CSF PCR was negative for HHV-7. There are limited pharmaceutical agents for the treatment of severe HHV-7 infection.…”

Section: Case Reportmentioning

confidence: 57%

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Α case of seronegative autoimmune encephalitis associated with human herpesvirus‐7 (HHV‐7)

Christou

Mastrogianni

Bourousis

et al. 2021

Journal of Medical Virology

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In the last 10 years, an increased number of patients presenting with acute encephalitis is being observed, a finding that is attributed to autoimmune mechanisms.Despite the fact that autoantibodies usually target the neuronal cell surface or synaptic proteins in the central nervous system (CNS), in many cases these remain undetectable, constituting a future diagnostic and therapeutic challenge. Human herpesvirus-7 (HHV-7) is proven to be a neurotropic virus, causing various neurological complications mostly in the adult population. We present the case of a 10-year-old girl, with confirmed active HHV-7 infection of the CNS, who developed acute seronegative autoimmune encephalitis. To our best knowledge, there is no literature concerning pediatric cases of autoimmune encephalitis following HHV-7 infection.

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Section: Case Reportmentioning

confidence: 57%

“…AESD is a new encephalopathy syndrome, characterized by biphasic seizures and reduced diffusion on MRI the first week of illness. It seems that HHV‐7 infection is linked to severe and uncommon neurologic entities 14,15 …”

Section: Discussionmentioning

confidence: 99%

Α case of seronegative autoimmune encephalitis associated with human herpesvirus‐7 (HHV‐7)

Christou

Mastrogianni

Bourousis

et al. 2021

Journal of Medical Virology

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“…AESD has been almost exclusively reported in the Japanese literature, comprising 34% of the acute encephalopathies seen and most commonly associated with HHV‐8 and influenza A viruses 2 . However, AESD has also been described in Europe, Australia, and North America 3–6 . Patients are usually previously well and present with altered level of consciousness and variable focal neurological signs usually coming from symmetrical lesions in the frontal‐temporal region; 34% recover completely, while 61% experience mild to moderate persistent deficits 1,2 .…”

Section: Introductionmentioning

confidence: 99%

“…2 However, AESD has also been described in Europe, Australia, and North America. [3][4][5][6] Patients are usually previously well and present with altered level of consciousness and variable focal neurological signs usually coming from symmetrical lesions in the frontal-temporal region; 34% recover completely, while 61% experience mild to moderate persistent deficits. 1,2 The condition is fatal in less than 2% of cases.…”

mentioning

confidence: 99%

Acute encephalopathy with biphasic seizures and late reduced diffusion with concurrent transverse myelitis

Austin‐Keiller,

Saint‐Martin,

Myers

2024

Epileptic Disorders

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We describe a patient with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) with unique features, including concurrent transverse myelitis. A 2‐year‐old previously healthy girl had clinical findings consistent with AESD, occurring in association with influenza A infection. The posterior brain regions were most severely affected, resulting in cortical blindness. She also developed bilateral limb weakness, and spine MRI revealed transverse myelitis in the cervical region. She was treated acutely with intravenous methylprednisolone. Serum anti‐myelin oligodendrocyte glycoprotein and anti‐aquaporin‐4 antibodies were negative, as was an anti‐extractable nuclear antigen panel. Although her clinical presentation was severe, she improved dramatically over the following months, and 6 months following initial presentation, her parents felt she had returned to baseline. This is the first report of AESD occurring in combination with transverse myelitis. The co‐occurrence of the two conditions is unlikely to be coincidental, suggesting that there may be a shared or overlapping immunological pathway involved. The patient's recovery was impressive, which could partially relate to the acute treatment with corticosteroids.

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Risk Factors of Prehospital Emergency Care for Acute Encephalopathy in Children With Febrile Status Epilepticus

Arai

Okanishi

Kanai

et al. 2023

Pediatric Neurology

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Acute encephalopathy with biphasic seizures and late reduced diffusion in a Spanish girl

Cited by 4 publications

References 10 publications

Α case of seronegative autoimmune encephalitis associated with human herpesvirus‐7 (HHV‐7)

Α case of seronegative autoimmune encephalitis associated with human herpesvirus‐7 (HHV‐7)

Acute encephalopathy with biphasic seizures and late reduced diffusion with concurrent transverse myelitis

Risk Factors of Prehospital Emergency Care for Acute Encephalopathy in Children With Febrile Status Epilepticus

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