Acute Encephalitis Syndrome and Scrub Typhus in India

Murhekar, Manoj

doi:10.3201/eid2308.162028

Cited by 18 publications

(17 citation statements)

References 3 publications

(5 reference statements)

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“…Now several recent studies found that as much as 20 to 30% of AES in endemic areas of India are due to scrub typhus and have suggested that early initiation of antimicrobials against Rickettsial infections (such as doxycycline and azithromycin) is critical to avoid fatality in AES. 5,6 Based on our clinical judgement and epidemiological experience, we had started doxycycline empirically, which was later proved to be right by laboratory tests.…”

Section: Discussionmentioning

confidence: 99%

Acute Disseminated Encephalomyelitis as a Complication of Scrub Typhus in Children

Roy

Chakrabartty

2018

J Pediatr Infect Dis

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Scrub typhus is a re-emerging threat throughout the world. The spectra of clinical pictures and possible complications are both varied and being increasingly reported. Acute disseminated encephalomyelitis (ADEM) is an infrequent demyelinating disorder of the central nervous system that is precipitated by infections and immunizations. There are only two documented cases of ADEM-associated scrub typhus published in the medical literature. We report the first pediatric case wherein a 5-year-old boy presented with high fever, altered sensorium, seizure, quadriparesis, and neck rigidity. He was ultimately diagnosed as a case of scrub typhus with ADEM. After treatment with intravenous doxycycline and methylprednisolone, the fever subsided but residual neurodeficits, such as inability to sit, stand, and talk, as well as bowel bladder dysfunctions persisted. He was subsequently transferred to long-term rehabilitation care.

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Section: Discussionmentioning

confidence: 99%

Acute Disseminated Encephalomyelitis as a Complication of Scrub Typhus in Children

Roy

Chakrabartty

2018

J Pediatr Infect Dis

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“…Every year, during the monsoon season and afterward, acute encephalitis syndrome (AES) emerges as an epidemic in different pockets of India. 3 Usually, the major number of cases is reported from a few states like Uttar Pradesh, West Bengal, Assam, and Tripura. 3 Acute encephalitis is a medical emergency, especially in children and physicians must decide on a proper treatment algorithm quickly.…”

Section: Discussionmentioning

confidence: 99%

Scrub Typhus Encephalitis: A Case Series from West Bengal

Thakur¹

2017

Bengal Physician Journal

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“…In India, rickettsial diseases have emerged as important vector-borne diseases. There is an increasing incidence of ST being reported across the country16; however, there are scarce reports on other major rickettsial diseases such as SFGR and TGR. Possible reasons for underreporting might be the lack of differential diagnosis, confusing clinical presentation and unawareness.…”

mentioning

confidence: 99%