Acute Effects of Two Angiotensin Receptor Blockers on Vascular Hemodynamics, Arterial Stiffness, and Oxidative Stress in Patients with Mild to Moderate Hypertension: An Open Label Parallel Group Study

Pathapati, Rama Mohan; Kumar, Meriga Rajesh; Chirra, Bhakthavatsala Reddy; Buchineni, Madhavulu; Tr, Sujith; Devaraju, Sreebhushan Raju; Naidu, M. U. R.

doi:10.1155/2013/186759

Cited by 8 publications

(8 citation statements)

References 19 publications

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“…It is well known that endothelial dysfunction, occurs in diabetic complications (6), associates with atherosclerotic progression (4) and elevates in oxidative stress. In diabetic SHRs, variable observation in terms of increased or decreased SBP and MAP are reported (41), (42), whereas, in our study ndings, the MAP and SBP values of diabetic SHRs were considerably higher, which could be due to the rapid destruction of nitric oxide (NO) in STZ induced SHRs (43), although, diminished NO bioactivity and bioavailability are key characteristics for arterial hypertension and endothelial disorders (44).…”

Section: Discussioncontrasting

confidence: 57%

Exogenous adiponectin with full Peroxisome proliferator-activated receptor agonists (pioglitazone) abrogates streptozotocin induced oxidative stress and vascular abnormalities in Spontaneously hypertensive rats.

Afzal

Sattar

Johns

et al. 2020

Preprint

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Background Oxidative stress, associates with metabolic and anthropometric perturbations, leads to reactive oxygen species production and decrease in plasma adiponectin concentration. We investigated pharmacodynamically the pathophysiological role and potential implication of exogenously administered adiponectin with full and partial peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonists on modulation of oxidative stress, metabolic dysregulation and antioxidant potential in streptozotocin induced Spontaneously hypertensive rats (SHR).Methods Group I (WKY) serve as normotensive control, whereas 42 male SHRs were randomized equally into 7 groups (n = 6), group II: SHR control, groups III: SHR diabetic control, group IV, V and VI treated with irbesartan (30 mg/kg), pioglitazone (10 mg/kg) and adiponectin (2.5 µg/kg), whereas, groups VII and VIII received co-treatments as irbesartan + adiponectin), (pioglitazone + adiponectin) respectively. Diabetes was induced using an intra-peritoneal injection of Streptozotocin (40 mg/kg). Plasma adiponectin, lipid contents, arterial stiffness with oxidative stress bio-markers were measured using an in-vitro and in-vivo analysis.Results Diabetic SHRs exhibited hyperglycaemia, hypertriglyceridemia, hypercholesterolemia, increased arterial stiffness with reduced plasma adiponectin and antioxidant enzymatic levels (P < 0.05). Diabetic SHRs pre-treated with pioglitazone and adiponectin separately exerted improvements in antioxidant enzyme activities, abrogated arterial stiffness, offset the increased production of reactive oxygen species and dyslipidaemic effects of STZ, except for blood pressure values which were more pronounced with irbesartan treated groups (all P < 0.05).Conclusions The combined treatment of exogenously administered adiponectin with full PPAR-γ agonist augmented the improvement in lipid contents and adiponectin concentration, restores arterial stiffness with antioxidant potential effects, indicating degree of synergism between adiponectin and full PPAR-γ agonists (pioglitazone).

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Section: Discussioncontrasting

confidence: 57%

Exogenous adiponectin with full Peroxisome proliferator-activated receptor agonists (pioglitazone) abrogates streptozotocin induced oxidative stress and vascular abnormalities in Spontaneously hypertensive rats.

Afzal

Sattar

Johns

et al. 2020

Preprint

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“…However, many studies do not support our findings. Pathapati et al; [20] found no statistically significant difference between the two groups with respect to reduction in SBP and DBP both. In another study by Luis DA et al; [21] both drugs had similar blood pressure lowering effect in hypertensive obese patients.…”

Section: Baseline Investigations Done In All Patients -mentioning

confidence: 89%

A Short Term Comparative Evaluation of Antihypertensive Efficacy and Safety of Olmesartan versus Telmisartan in Patients of Stage 1 Hypertension

Gupta¹,

Chandra²,

Kapoor³

et al. 2016

SJAMS

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Angiotensin type-1 receptor blockers (ARBs) are being one of the first-line treatments for hypertension. Despite the availability of various types of ARBs, there are no comparative studies of their effects in North Indian patients. In this open-label, prospective, randomized study, we compared the antihypertensive effects of olmesartan (20 mg/day) versus telmisartan (40 mg/day) in newly diagnosed patients of stage I hypertension as defined under JNC-VII guidelines. 60 patients were randomized into 2 groups. The odd numbers was allotted to olmesartan (group A) & even numbers to telmisartan (group B). Group A was allotted olmesartan 20 mg/day and group B was given telmisartan 40 mg/day for 12 weeks. Efficacy and safety was assessed by the changes in the blood pressure in terms of adverse event rates and control of blood pressure, including abnormal clinical laboratory variables related to kidney function and serum electrolyte levels. The follow up was done at 2, 4, 8 and 12 weeks. We analyzed the blood pressure lowering effects of each drug by blood pressure monitoring at 0, 2, 4, 8, 12 weeks and metabolic parameters were assessed. Olmesartan lowered mean systolic and diastolic blood pressure more significantly than telmisartan. Our results indicate that olmesartan has more potent arterial blood pressure lowering effect than telmisartan. None of the patient complained about any adverse effect with the use of either olmesartan (20mg per day) or telmisartan (40mg/day).

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“…Under water shortage conditions, excessive loss of perspiration may damage the body's cardiovascular and thermoregulatory function (7)(8)(9). In response to the high temperature, the human body needs heat dissipation and expansion of body surface blood vessels, the amount of blood in the body surface increases, and the amount of blood supply for heart, cerebrovascular is relatively reduced, leading to cerebral ischemic and hypoxic reactions (10,11). The experiment results showed that, with the increase of heat exposure intensity, the rat heart rate had a tendency to slow down.…”

Section: Discussionmentioning

confidence: 99%

Effect of dehydration heat exposure on thoracic aorta reactivity in rats

et al. 2016

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Abstract. The aim of the present study was to investigate the effect of one week dehydration heat exposure on thoracic aorta reactivity in rats. Eighteen Male Sprague-Dawley rats were randomly divided into 3 groups (n=6 each group): Control group (CN), heat exposure group (HE), dehydration heat exposure group (DHE). The CN group was exposed to a room temperature of 24˚C, while the HE and DHE groups were exposed to a heat temperature of 32˚C. After 7 days of heat exposure, the heart rate and blood pressure of the rats were measured, and the noradrenaline (NA)-induced contraction on the aorta rings was measured by tension recording. The average contents of malondialdehyde (MDA) and superoxide dismutase (SOD) in serum were detected using ELISA. The expression of apoptotic genes in the thoracic aorta was measured using RT-PCR. Compared with CN, the heart rate in the HE and DHE groups had a tendency to become retarded, but there was no significant difference (P>0.05). In the HE group, the systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) of the rats were significantly higher than that of the CN (P<0.05). In the DHE group, the SBP of rats was significantly higher than that of the CN (P<0.05), while the SBP, DBP, and MAP of the rats were decreased compared to the rats in the HE group, although there was no statistical significance (P>0.05). In the HE and DHE groups, the NA-induced contraction on the rats thoracic aorta ring was larger than that of the CN (P<0.05), albeit there was no significant difference between the HE and DHE groups (P>0.05). The serum SOD content decreased in the HE and DHE groups, however, the reduction was significant only in the DHE group (P<0.05). The content of MDA in serum was significantly increased in the DHE group (P<0.05). The expression of BAX was significantly upregulated whereas Bcl2 expression was decreased in the DHE group (P<0.05). The results showed that a high temperature was harmful to the body, especially in the case of lack of food and water. Additionally, the heat exposure elevated blood pressure, and increased arterial reactivity, which were related to the elevated production of MDA, led to the impaired production of SOD, and an increase of cell apoptosis. These findings are useful to understand the influence of dehydrated heat exposure on the vascular function, and they provide certain theoretical and experimental guidance for protection under high temperature. IntroductionHigh temperature has a severe influence on an individual's work, life and body, and it is easy for the individual to become exhausted, irritable and exasperation. A high temperature constitutes a risk factor for the occurrence of cerebrovascular, heart and respiratory diseases; consequently, the death rate increases correspondingly, particularly among the elderly (1-3). At present, the effect of a high temperature especially the dehydration of thermal on the physiological function of human, is lacking in terms of comprehensive knowledge and understanding.On the ...

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Acute Effects of Two Angiotensin Receptor Blockers on Vascular Hemodynamics, Arterial Stiffness, and Oxidative Stress in Patients with Mild to Moderate Hypertension: An Open Label Parallel Group Study

Cited by 8 publications

References 19 publications

Exogenous adiponectin with full Peroxisome proliferator-activated receptor agonists (pioglitazone) abrogates streptozotocin induced oxidative stress and vascular abnormalities in Spontaneously hypertensive rats.

Exogenous adiponectin with full Peroxisome proliferator-activated receptor agonists (pioglitazone) abrogates streptozotocin induced oxidative stress and vascular abnormalities in Spontaneously hypertensive rats.

A Short Term Comparative Evaluation of Antihypertensive Efficacy and Safety of Olmesartan versus Telmisartan in Patients of Stage 1 Hypertension

Effect of dehydration heat exposure on thoracic aorta reactivity in rats

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