Acute effects of the resistance exercise associated with different blood flow restriction pressures on bone remodeling biomarkers

Copatti, Sedinei Lopes; Bonorino, Sabrina Lencina; Copatti, Anieli da Costa; Saretto, Chrystianne Barros; Grossl, Fernando Schorr; Silva-Grigoletto, Marzo Edir Da; Córralo, Vanessa da Silva; Sá, Clodoaldo Antônio De

doi:10.1016/j.jesf.2022.02.005

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…However, a recently published article used cycling ergometer-based training performed twice per week with BFR and found that this prehabilitation training induced significant improvements in preoperative as well as postoperative clinical outcomes among patients with knee OA (21). In the same vein, another recent study (13) that analyzed the acute responses to LL-BFR in young females found that protocols with BFR were more effective than LL resistance exercise alone to promote a metabolic condition favorable to bone anabolism. In addition, another recent study ( 8) that looked at acute and chronic bone marker and endocrine responses to resistance exercise with and without BFR in young men found that LL-BFR was effective for stimulating acute bone formation marker and hormone responses.…”

Section: Discussionmentioning

confidence: 99%

Neuromuscular Responses and Perceptions of Health Status and Pain-Related Constructs in End-Stage Knee Osteoarthritis During Resistance Training With Blood Flow Restriction

Ogrezeanu,

López-Bueno,

Sanchís-Sánchez

et al. 2023

Journal of Strength &Amp; Conditioning Research

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Ogrezeanu, DC, López-Bueno, L, Sanchís-Sánchez, E, Carrasco, JJ, Cuenca-Martínez, F, Suso-Martí, L, López-Bueno, R, Cruz-Montecinos, C, Martinez-Valdes, E, Casaña, J, and Calatayud, J. Neuromuscular responses and perceptions of health status and pain-related constructs in end-stage knee osteoarthritis during resistance training with blood flow restriction. J Strength Cond Res XX(X): 000–000, 2023—We aimed to evaluate the neuromuscular responses and their relationship with health status, kinesiophobia, pain catastrophizing, and chronic pain self-efficacy in patients with end-stage knee osteoarthritis during acute resistance training with different levels of blood flow restriction (BFR). Seventeen patients with end-stage knee osteoarthritis participated in 3 experimental sessions separated by 3 days, performing 4 sets of knee extensions with low load and 3 levels of concurrent BFR performed in a random order: control (no BFR), BFR at 40% arterial occlusion pressure (AOP), and BFR at 80% AOP. Normalized root-mean-square (nRMS), nRMS spatial distribution (centroid displacement, modified entropy, and coefficient of variation), and normalized median frequency (nFmed) were calculated from the vastus medialis (VM) and lateralis (VL) using high-density surface electromyography. Subjects were asked to report adverse effects after the sessions. In the VM, nRMS was higher with 80% AOP than with 40% AOP (p = 0.008) and control (p < 0.001), whereas there were no differences between conditions in the VL. Normalized root-mean-square also showed an association with pain catastrophizing, chronic pain self-efficacy, and health status (VM: −0.50, 0.49, −0.42; VL: −0.39, 0.27, −0.33). Spatial distribution varied between conditions but mostly in the VL. Overall, nFmed did not vary, with only a slight increase in the VL with 40% AOP, between set 3 and 4. BFR during knee extensions at 80% AOP increases VM activity and VL amplitude distribution more than 40% AOP and control. Importantly, muscle activity increases are modulated by pain catastrophizing, chronic pain self-efficacy, and health status in these patients, and kinesiophobia seems to especially modulate entropy.

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Section: Discussionmentioning

confidence: 99%

Neuromuscular Responses and Perceptions of Health Status and Pain-Related Constructs in End-Stage Knee Osteoarthritis During Resistance Training With Blood Flow Restriction

Ogrezeanu,

López-Bueno,

Sanchís-Sánchez

et al. 2023

Journal of Strength &Amp; Conditioning Research

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The Bone Biomarker Response to an Acute Bout of Exercise: A Systematic Review with Meta-Analysis

et al. 2022

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Idiosyncratic bone responses to blood flow restriction exercise: new insights and future directions

Hughes,

Centner

2024

Journal of Applied Physiology

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Applying blood flow restriction (BFR) during low load exercise induces beneficial adaptations of the myotendinous and neuromuscular system. Despite the low mechanical tension, BFR exercise facilitates a localized hypoxic environment and increase in metabolic stress, widely regarded as the primary stimulus for tissue adaptations. First evidence indicates that low load BFR exercise is effective in promoting an osteogenic response in bone, although this has previously been postulated to adapt primarily during high-impact weight-bearing exercise. Besides studies investigating the acute response of bone biomarkers following BFR exercise, first long-term trials demonstrate beneficial adaptations in bone in both healthy and clinical populations. Despite the increasing number of studies, the physiological mechanisms are largely unknown. Moreover, heterogeneity in methodological approaches such as biomarkers of bone metabolism measured, participant and study characteristics, and time-course of measurement render it difficult to formulate accurate conclusions. Furthermore, incongruity in the methods of BFR application (e.g., cuff pressure) limits the comparability of datasets and thus hinders generalizability of study findings. Appropriate use of biomarkers, effective BFR application and befitting study design has the potential to progress knowledge on the acute and chronic response of bone to BFR exercise and contribute toward the development of a novel strategy to protect or enhance bone health. Therefore, the purpose of the present synthesis review is to: i) evaluate current mechanistic evidence; ii) discuss and offer explanations for similar and contrasting data findings; and iii) create a methodological framework for future mechanistic and applied research.

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Acute effects of the resistance exercise associated with different blood flow restriction pressures on bone remodeling biomarkers

Cited by 3 publications

References 39 publications

Neuromuscular Responses and Perceptions of Health Status and Pain-Related Constructs in End-Stage Knee Osteoarthritis During Resistance Training With Blood Flow Restriction

Neuromuscular Responses and Perceptions of Health Status and Pain-Related Constructs in End-Stage Knee Osteoarthritis During Resistance Training With Blood Flow Restriction

The Bone Biomarker Response to an Acute Bout of Exercise: A Systematic Review with Meta-Analysis

Idiosyncratic bone responses to blood flow restriction exercise: new insights and future directions

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