Acute effects of splint immobilization of the forearm on in vivo microcirculation and histomorphology of the human skin

Altıntaş, Ahmet; Vogt, Peter M.; Altintas, M.A.

doi:10.1002/jemt.22317

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…In contrast, Tp and 50% decay time tended to decrease with increase in inter-probe distance. Since deep tissues that contain muscle have more capillaries than epidermal tissue [10,11], more vasodilator metabolites accumulate and dilate blood vessels during occlusion [12,13]. This is supported by the simultaneous DCS and tissue oxygen saturation measurements performed by Yu et al [9], showing that deeper tissues consume more oxygen than the shallow tissues during cuff occlusion.…”

Section: Discussionmentioning

confidence: 90%

Detection of Blood Flow Speed in Shallow and Deep Tissues Using Diffuse Correlation Spectroscopy

Nakabayashi

Ono

2017

ABE

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Diffuse correlation spectroscopy (DCS) is an emerging optical technique for noninvasive measurement of hemodynamics of living tissues. Using emitter and detector optical probes attached to the body surface, DCS estimates the mean speed of blood ow in the tissue, through which the emitted near-infrared light propagates (blood ow index: BFI). The advantage of DCS is that the mean blood ow in deeper tissues such as muscle layers can be measured noninvasively. To investigate the sensitivity of DCS in detecting the physiological changes of blood ow in deep and shallow tissues, we measured the blood ow speed in 14 healthy participants during a reactive hyperemia test and skin temperature changes. In the reactive hyperemia test, blood ow returned to the steady state faster in deep tissues than in shallow tissues, and temperature-dependent reallocation of local blood ow in shallow and deep tissues was clearly observed. These results demonstrate that DCS can measure the differences in physiological blood ow dynamics in deep and shallow tissues, suggesting the potential use of DCS to noninvasively quantify changes at microcirculation level in both shallow and deep tissue layers.Keywords: diffuse correlation spectroscopy, blood ow speed, reactive hyperemia test, thermoregulatory control of blood ow.Adv Biomed Eng. 6: pp. 53-58, 2017.

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Section: Discussionmentioning

confidence: 90%

Detection of Blood Flow Speed in Shallow and Deep Tissues Using Diffuse Correlation Spectroscopy

Nakabayashi

Ono

2017

ABE

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“…We also reported that the hypoxic condition of the skeletal muscle induced by immobilization promoted the increase in myofibroblasts, which facilitated muscle fibrosis (7). In human subjects, Altintas et al demonstrated that immobilization of the forearm by splinting for 72 h reduced skin microcirculation (30). We thus speculate that in addition to the mechanical stimulation to the immobilized muscle, an increase in the blood flow in the immobilized muscle is needed to inhibit muscle fibrosis.…”

Section: Discussionmentioning

confidence: 59%

Cyclic muscle twitch contraction inhibits immobilization-induced muscle contracture and fibrosis in rats

Yoshimura¹,

Sakamoto

Honda

et al. 2016

Connective Tissue Research

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We investigated the effects of cyclic muscle twitch contraction caused by neuromuscular electrical stimulation (NMES) on immobilization-induced muscle contracture and fibrosis in rats. Twenty-nine rats were divided into control, immobilization, and immobilization with muscle contraction groups. The ankle joints of the immobilization and muscle contraction rats were fixed in full plantar flexion with a plaster cast for 4 weeks. In the muscle contraction group, cyclic muscle twitch contraction of the soleus muscle was induced using a commercial device (1 Hz, 4 ± 2 mA, 60 min/day, 5 times/week) with the ankle joint immobilized. The dorsiflexion range of ankle joint motion in the muscle contraction group was significantly greater than that in the immobilization group. The expressions of fibrosis-related genes (i.e., hypoxia inducible factor-1α, transforming growth factor-β1, α-smooth muscle actin, and types I and III collagen) were significantly decreased in the muscle contraction group compared to the immobilization group. The fluorescence intensities of type I and type III collagen in the perimysium and endomysium in the muscle contraction group were significantly decreased compared to the immobilization group. These results suggest that cyclic muscle twitch contraction induced by NMES might alleviate skeletal muscle fibrosis, reducing immobilization-induced muscle contracture.

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“…The immobilization causes changes in several tissues such as bone (JU, SONE, OHNARU et al, 2012), joint capsule (ANDO, SUDA, HAGIWARA et al, 2012), cartilage (PORTINHO, BOIN and BERTOLINI, 2008), skin (ALTINTAS, VOGT and ALTINTAS, 2014) and tendon (ARO, VIDAL, TOMIOSSO et al, 2008). But, despite being a resource used in various types of injuries, it is little used in lesions of skeletal muscle, being observed that 5 and 14 days of immobilization is no significant loss in strength and muscle tropism.…”

Section: Introductionmentioning

confidence: 99%

Remobilization in aquatic medium of rat soleus immobilized in lengthening

et al. 2015

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Introduction: The aim of this study was to evaluate histomorphometrically two protocols of aquatic exercise on soleus of rats immobilized in dorsiflexion. Material and Methods: It was used 30 Wistar rats, randomly distributed in five groups: G1 -right hindlimb immobilized in maximum dorsiflexion, for 15 consecutive days, after this the animals were euthanized; G2 -also immobilized in maximum dorsiflexion, for 15 consecutive days, then the animals were freely remobilized; G3 -submitted to remobilization by free swim; G4 -submitted to remobilization with overload of 10% of body weight; G5 -remobilization by jumping in water with overload of 50% of body weight. The immobilization model used was made by plaster cast directly in the lower right limb of each animal. After removing the immobilization, the animals were submitted to remobilization for 10 days according to the group. At the end of the remobilization, the right and left soleus muscles were isolated, cleaned and weighed on an analytical balance, each muscle was sectioned longitudinally, and the medial part was used to evaluation of longitudinal parameters and the medial for cross-sectional assessment. Results: for the estimate of sarcomeres in series, muscular and sarcomere length there were not significant differences. For the muscle mass and fibers diameter there were difference between right and left soleus, but not for the groups. Conclusion: the used protocol of immobilization/remobilization was insufficient to cause changes in the overall longitudinal soleus, but the immobilization produced reduced mass and diameter of the fibers, which are not reversed with remobilization protocols.

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Acute effects of splint immobilization of the forearm on in vivo microcirculation and histomorphology of the human skin

Cited by 5 publications

References 25 publications

Detection of Blood Flow Speed in Shallow and Deep Tissues Using Diffuse Correlation Spectroscopy

Detection of Blood Flow Speed in Shallow and Deep Tissues Using Diffuse Correlation Spectroscopy

Cyclic muscle twitch contraction inhibits immobilization-induced muscle contracture and fibrosis in rats

Remobilization in aquatic medium of rat soleus immobilized in lengthening

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