INTRODUCTIONChronic heart failure (CHF) is the final stage of heart disease and one of the important reasons for morbidity and mortality globally (1, 2). The overall prevalence of HF is 1%-2% and increases with age, and therefore, is more than 10% in patients over 70-years (3).CHF is a complex clinical syndrome with the left ventricle unable to fill with or eject blood owing to structural or functional impairment. Coronary artery diseases (CAD) and hypertension are two important causes of HF. The most important symptoms of CHF are fatigue, dyspnea, and exercise intolerance accompanied by a decreased quality of life (4). Autonomic imbalance, sympathetic activation, and vagal withdrawal, in CHF, results from biochemical alterations in central autonomic nuclei as well as the altered function of peripheral autonomic reflexes to improve cardiac output via increasing heart rate and stroke volume to compensate for perfusion problems. Prolongation of this condition becomes maladaptive and contributes to the progression of the disease and fatal events because of impairment of neuroendocrine and baroreceptor activation, which causes vasoconstriction increased oxygen consumption, and high hemodynamic load (5-7).The autonomic function can be evaluated through baroreceptor sensitivity, measuring heart rate variability (HRV), heart rate recovery (HRR), and muscle sympathetic ABSTRACT Objective: Autonomic imbalance in patients with chronic heart failure (CHF) and cardiovascular diseases (CVD) is characterized by reduced parasympathetic and enhanced sympathetic activity. Aerobic exercise improves autonomic function in patients with CHF and CVD. However, little is known about the effects of resistance training (RT) on cardiac autonomic function. Therefore, we aimed to investigate the effects of RT added on aerobic training on autonomic function in patients with CHF and CVD.
Data sources:The relevant clinical trials were searched in PubMed, Physiotherapy evidence Database (PEDro, Science Direct and Google Scholar databases using the following keywords, "resistance or strength training", "chronic heart failure", "coronary artery disease", "myocardial infarction", "hypertension", "cardiovascular disease", "heart rate variability (HRV)", "heart rate recovery (HRR)", "muscle sympathetic nerve activity (MSNA)", and "autonomic function".Data synthesis: Twelve articles with 323 subjects were eligible to be evaluated. The outcome measures included HRV, HRR, and MSNA. There were seven studies on CHF, two on CAD, and three studies on hypertension. Meta-analysis of all the studies showed that combined RT and aerobic training decreased MSNA significantly in patients with CHF and CAD (mean difference: -3.796; CI: -6.779 to 0.813; p=0.013; I 2 =93.5%). No study evaluated the effects of RT or combined training on HRR.
Conclusion:We could not find sufficient data about the effects of RT alone on HRV and HRR, but the results showed that combined RT and aerobic training improved MSNA in patients with CHF and CAD, significantly. Further studies with...