Acute effects of radioiodine therapy on the voice and larynx of basedow-graves patients

Isolan-Cury, Roberta Werlang; Monte, Osmar; Cury, Adriano Namo; Silva, Marta Assumpção de Andrada e; Duprat, André de Campos; Marone, Marília Martins Silveira; Almeida, Renata de Albuquerque Cavalcanti; Iglesias, Alexandre

doi:10.1016/s1808-8694(15)31092-2

Cited by 5 publications

(4 citation statements)

References 15 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By any definition of good voice outcomes, comparison of the 3 groups classified according to RIT dose did not reveal any functional differences. This finding is in line with a previous study on the impact of RIT on vocal quality in patients with Graves disease (30). Recent studies also report no statistical differences in hoarseness associated with RIT dose (31,32).…”

Section: Discussionsupporting

confidence: 92%

Administration of Radioactive Iodine Therapy Within 1 Year After Total Thyroidectomy Does Not Affect Vocal Function

Ryu

et al. 2015

J Nucl Med

View full text Add to dashboard Cite

The purpose of this study was to evaluate the impact of radioactive iodine therapy (RIT) on vocal function during the early follow-up period after total thyroidectomy (TT) using perceptive and objective measurements, questionnaires regarding subjective symptoms, and data on vocal function in a prospectively enrolled and serially followed thyroid cancer cohort. Methods: Of 212 patients who underwent TT and were screened between January and December 2010 at our hospital, 160 were included in the final analysis. Patients with the following histories were excluded: lateral neck dissection, organic vocal fold disease, external radiotherapy, and voice evaluation during thyroxine withdrawal. Patients were stratified into 3 groups: TT, TT with low-dose RIT (1.1-2.2 GBq), and TT with high-dose RIT ($3.7 GBq). Voice evaluations were performed before surgery and at 1, 6, and 12 mo after TT. Results: Vocal characteristics were altered after TT, including changes on the grade, roughness, and strain scale; increased amplitude perturbation; decreased fundamental frequency; narrowed pitch range; and global disturbances in subjective functional parameters on the voice handicap index. However, the degree of vocal changes among the 3 groups did not significantly differ within the 1-y postoperative follow-up period. According to the results of subgroup analyses of patients who demonstrated good voice outcomes after TT, there were no significant functional differences among the 3 groups. Conclusion: RIT at any dose does not affect vocal function within 1 y of TT.

show abstract

Section: Discussionsupporting

confidence: 92%

Administration of Radioactive Iodine Therapy Within 1 Year After Total Thyroidectomy Does Not Affect Vocal Function

Ryu

et al. 2015

J Nucl Med

View full text Add to dashboard Cite

show abstract

“…There are few studies on the impact of RIA implementation on voice quality. [20][21][22] We did not find any correlation between RIA and voice change, consistent with a previous study by Ryu et al 22 Previous studies on the effects of the extent of thyroidectomy have produced contradictory results. [23][24][25] In this study, significantly greater differences in the results of perceptual and subjective analyses were found for the total thyroidectomy group compared to the lobectomy group.…”

Section: Discussionsupporting

confidence: 90%

“…With the use of a standardised technique that minimises superior and recurrent laryngeal nerve injuries and manipulation of the strap muscles, surgical factors do not appear to influence voice changes. There are few studies on the impact of RIA implementation on voice quality 20–22 . We did not find any correlation between RIA and voice change, consistent with a previous study by Ryu et al 22 Previous studies on the effects of the extent of thyroidectomy have produced contradictory results 23–25 .…”

Section: Discussionsupporting

confidence: 90%

Prospective voice assessment after uncomplicated thyroidectomy: A comprehensive analysis of a single centre experience

Nam

Bae

Lee

et al. 2022

Clinical Otolaryngology

View full text Add to dashboard Cite

Objectives Voice change after uncomplicated thyroidectomy has been an important issue in the field of thyroid surgery. The aim of this study was to promote understanding of voice change after uncomplicated thyroidectomy by analysing the results for a large number of patients from a single institute. Design We retrospectively reviewed the medical records of 2879 consecutive patients who underwent thyroidectomy and voice evaluation between January 2014 and December 2019 in a single institute. All the patients had their vocal status assessed using videostroboscopy, acoustic voice analyses, aerodynamic study, and Thyroidectomy‐related Voice and Symptom Questionnaire (TVSQ) scores preoperatively and at 1, 3, and 6 months postoperatively. We analysed the pattern of voice changes over time and differences in voice parameters based on clinical factors. To confirm the usefulness of the TVSQ, the correlation between TVSQ scores and objective parameters was analysed. Lastly, predictive factors for persistent voice symptoms were analysed. Setting Tertiary referral hospital. Results The frequency ranges and TVSQ scores exhibited significant deterioration until 6 months following surgery. Among clinical factors, the extents of thyroidectomy and neck dissection were associated with worse voice parameters. The TVSQ score was significantly correlated with objective voice parameters. The extents of thyroidectomy and neck dissection were predictive of persistent voice symptoms at 6 months after thyroidectomy. Conclusion After uncomplicated thyroidectomy, most voice parameters tended to recover, but some parameters remained aggravated even at 6 months after surgery. With more extensive surgery, worse voice quality and the higher risk of persistent voice symptoms may be anticipated.

show abstract

“…Fifteen patients with thyroid cancer underwent additional radioiodine therapy. Since I-131 therapy does not affect voice quality, the study-group could be considered homogenous from this perspective [16,17]. The status of the glottis (particularly the mobility of the vocal folds) was evaluated using a 70° rigid endoscope during regular control examinations of patients under local anesthesia.…”

Section: Patientsmentioning

confidence: 99%

Functional results of endoscopic arytenoid abduction lateropexy for bilateral vocal fold palsy

Rovó

Matievics

Sztanó

et al. 2021

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Purpose Endoscopic arytenoid abduction lateropexy (EAAL) is a reliable surgical solution for the minimally invasive treatment of bilateral vocal fold palsy (BVFP), providing a stable airway by the lateralization of the arytenoid cartilages with a simple suture. The nondestructive manner of the intervention theoretically leads to higher regeneration potential, thus better voice quality. The study aimed to investigate the respiratory and phonatory outcomes of this treatment concept. Methods 61 BVFP patients with significant dyspnea associated with thyroid/parathyroid surgery were treated by unilateral EAAL. Jitter, Shimmer, Harmonics to Noise Ratio, Maximum Phonation Time, Fundamental frequency, Voice Handicap Index, Dysphonia Severity Index, Friedrich’s Dysphonia Index, Global-Roughness-Breathiness scale, Quality of Life, and Peak Inspiratory Flow were evaluated 18 months after EAAL. Results All patients had a stable and adequate airway during the follow-up. Ten patients (16.4%) experienced complete bilateral motion recovery with objective acoustic parameters in the physiological ranges. Most functional results of the 13 patients (21.3%) with unilateral recovery also reached the normal values. Fifteen patients (24.6%) had unilateral adduction recovery only, with slightly impaired voice quality. Eleven patients (18.0%) had false vocal fold phonation with socially acceptable voice. In 12 patients (19.7%) no significant motion recovery was detected on the glottic level. Conclusion EAAL does not interfere with the potential regeneration process and meets the most important phoniatric requirements while guaranteeing the reversibility of the procedure—therefore serving patients with transient palsy. Further, a socially acceptable voice quality and an adequate airway are ensured even in cases of permanent bilateral vocal fold paralysis.

show abstract

Acute effects of radioiodine therapy on the voice and larynx of basedow-graves patients

Abstract: Radioiodine therapy does not affect voice quality.

Cited by 5 publications

References 15 publications

Administration of Radioactive Iodine Therapy Within 1 Year After Total Thyroidectomy Does Not Affect Vocal Function

Administration of Radioactive Iodine Therapy Within 1 Year After Total Thyroidectomy Does Not Affect Vocal Function

Prospective voice assessment after uncomplicated thyroidectomy: A comprehensive analysis of a single centre experience

Functional results of endoscopic arytenoid abduction lateropexy for bilateral vocal fold palsy

Contact Info

Product

Resources

About