Acute Effects of Nutritive and Non-Nutritive Sweeteners on Postprandial Blood Pressure

Abstract

Postprandial hypotension (PPH) is under-recognised, but common, particularly in the elderly, and is of clear clinical importance due to both the independent association between PPH and an increase in mortality and lack of effective management for this condition. Following health concerns surrounding excessive consumption of sugar, there has been a trend in the use of low- or non-nutritive sweeteners as an alternative. Due to the lack of literature in this area, we conducted a systematic search to identify studies relevant to the effects of different types of sweeteners on postprandial blood pressure (BP). The BP response to ingestion of sweeteners is generally unaffected in healthy young subjects, however in elderly subjects, glucose induces the greatest decrease in postprandial BP, while the response to sucrose is less pronounced. The limited studies investigating other nutritive and non-nutritive sweeteners have demonstrated minimal or no effect on postprandial BP. Dietary modification by replacing high nutritive sweeteners (glucose, fructose, and sucrose) with low nutritive (d-xylose, xylitol, erythritol, maltose, maltodextrin, and tagatose) and non-nutritive sweeteners may be a simple and effective management strategy for PPH.

Non‐pharmacological interventions for older adults with postprandial hypotension: A scoping review

“…Having coffee with meals may also benefit older adults with PPH, but the finding was validated among 'healthy' older adults who showed a postprandial decrease in SBP but may not have a PPH diagnosis (Ong et al, 2014). Additionally, researchers proposed that using low/non-nutritive sweeteners (including xylose, erythritol, or sucralose)-which may have little effect on maintaining the homeostasis of postprandial SBP-to replace high-nutritive sweeteners (including glucose, fructose or sucrose) may be promising for older adults with PPH (Pham et al, 2019). This proposal may remain unvalidated in older adults with PPH as of the retrieval date of this review.…”

“…With baroreflex dysfunction, the peripheral blood volume is not timely and adequately compensated for by an increase in heart rate, peripheral vascular resistance, stroke volume and cardiac output. This leads to a decrease in postprandial SBP (Pham et al, 2019). PPH not only increases the risk of falls (Nair et al, 2016), syncope (Brignole et al, 2018), and new cardiovascular and cerebrovascular diseases but is also a prominent risk factor for death in older people (Jenkins et al, 2022).…”

Empirical facts about Erythritol’s effects on whole body systems: A systematic Review

“…Taking 30g of Erythritol for 2-4 weeks lowers small intestine glucose absorption, improves arterial endothelial function, reduces serum levels, and mesenteric artery blood flow doubles (9,8,11). Cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1), and peptide tyrosine (PYY) reduce gastric emptying and the desire for further energy consumption (19).…”

Determination of the Chemical Stability of Cyanocobalamin in Medical Food by a Validated Immunoaffinity Column-Linked HPLC Method

“…Nutritive sweeteners commonly found in beverages and foods contain sucrose, fructose, and glucose. Some other sweeteners with lower energy levels such as xylitol, maltose, maltodextrin, and stevia have been used [29]. Sorbitol, a well-known polyol sweetener, has glycemic regulation properties [30].…”