Acute Effects of Nitrate-Rich Beetroot Juice on Blood Pressure, Hemostasis and Vascular Inflammation Markers in Healthy Older Adults: A Randomized, Placebo-Controlled Crossover Study

Raubenheimer, Kyle; Hickey, Danica K.; Leveritt, Michael; Fassett, Robert G.; Zevallos, Joaquin Ortiz de; Allen, Jason D.; Briskey, David; Parker, Tony J.; Kerr, Graham; Peake, Jonathan M.; Pecheniuk, Natalie M.; Neubauer, Oliver

doi:10.3390/nu9111270

Cited by 63 publications

(50 citation statements)

References 37 publications

(107 reference statements)

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“…These improvements were associated with lower aortic ROS and IL-1 , IL-6, IFN-and TNF- (Sindler et al, 2011). In older adults, nitrate-rich beetroot juice decreased blood pressure and monocyte/platelet aggregation (Raubenheimer et al, 2017).…”

Section: Dietary Interventionsmentioning

confidence: 86%

“…These improvements were associated with lower aortic ROS and IL‐1β, IL‐6, IFN‐γ and TNF‐α (Sindler et al., ). In older adults, nitrate‐rich beetroot juice decreased blood pressure and monocyte/platelet aggregation (Raubenheimer et al., ). Trehalose, a disaccharide which has autophagy‐stimulating effects, improves EDD in both older humans and mice, and the aortas from old mice treated with trehalose exhibit lower IL‐1β, IL‐6 and TNF‐α production (LaRocca et al., ).…”

Section: Interventions To Ameliorate Age‐related Inflammation and Artmentioning

confidence: 99%

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Inflammation as a mediator of arterial ageing

Trott

Fadel

2019

Experimental Physiology

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New Findings What is the topic of this review?This review summarizes and synthesizes what is known about the contribution of inflammation to age‐related arterial dysfunction. What advances does it highlight?This review details observational evidence for the relationship of age‐related inflammation and arterial dysfunction, insight from autoimmune inflammatory diseases and their effects on arterial function, interventional evidence linking inflammation and age‐related arterial dysfunction, insight into age‐related arterial inflammation from preclinical models and interventions to ameliorate age‐related inflammation and arterial dysfunction. Abstract Advanced age is a primary risk factor for cardiovascular disease, the leading cause of death in the industrialized world. Two major components of arterial ageing are stiffening of the large arteries and impaired endothelium‐dependent dilatation in multiple vascular beds. These two alterations are major contributors to the development of overt cardiovascular disease. Increasing inflammation with advanced age is likely to play a role in this arterial dysfunction. The purpose of this review is to synthesize what is known about inflammation and its relationship to age‐related arterial dysfunction. This review discusses both the initial observational evidence for the relationship of age‐related inflammation and arterial dysfunction and the evidence that inflammatory autoimmune diseases are associated with a premature arterial ageing phenotype. We next discuss interventional and mechanistic evidence linking inflammation and age‐related arterial dysfunction in older adults. We also attempt to summarize the relevant evidence from preclinical models. Lastly, we discuss interventions in both humans and animals that have been shown to ameliorate age‐related arterial inflammation and dysfunction. The available evidence provides a strong basis for the role of inflammation in both large artery stiffening and impairment of endothelium‐dependent dilatation; however, the specific inflammatory mediators, the initiating factors and the relative importance of the endothelium, smooth muscle cells, perivascular adipose tissue and immune cells in arterial inflammation are not well understood. With the expansion of the ageing population, ameliorating age‐related arterial inflammation represents an important potential strategy for preserving vascular health in the elderly.

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Section: Dietary Interventionsmentioning

confidence: 86%

Section: Interventions To Ameliorate Age‐related Inflammation and Artmentioning

confidence: 99%

Inflammation as a mediator of arterial ageing

Trott

Fadel

2019

Experimental Physiology

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“…Acute effects after supplementation of BRJ High blood pressure (BP) is a known risk factor for cardiovascular diseases (Raubenheimer et al 2017). Blood pressure reduction as one of the potential effects of dietary nitrate has been thoroughly investigated.…”

Section: Effect On Blood Pressurementioning

confidence: 99%

“…Webb et al (2008) studied whether consumption of dietary nitrate through BRJ leads to acute BP reduction following bioconversion by oral bacteria to nitrite and subsequently to NO (Webb et al 2008). NO is known to be a potent vasodilator, and BRJ was indeed shown to cause a BP reduction (Curry et al 2016;Hobbs et al 2012;Jonvik et al 2016;Kapil et al 2010;McDonagh et al 2018;Raubenheimer et al 2017;Webb et al 2008). This effect is especially significant when concentrated BRJ is compared to non-concentrated BRJ, beetrootflapjack and BRJ containing soluble beetroot-crystals (McDonagh et al 2018).…”

Section: Effect On Blood Pressurementioning

confidence: 99%

The benefits and risks of beetroot juice consumption: a systematic review

Zamani

Joode

Hossein

et al. 2020

Critical Reviews in Food Science and Nutrition

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Beetroot juice (BRJ) has become increasingly popular amongst athletes aiming to improve sport performances. BRJ contains high concentrations of nitrate, which can be converted into nitric oxide (NO) after consumption. NO has various functions in the human body, including a vasodilatory effect, which reduces blood pressure and increases oxygen-and nutrient delivery to various organs. These effects indicate that BRJ may have relevant applications in prevention and treatment of cardiovascular disease. Furthermore, the consumption of BRJ also has an impact on oxygen delivery to skeletal muscles, muscle efficiency, tolerance and endurance and may thus have a positive impact on sports performances. Aside from the beneficial aspects of BRJ consumption, there may also be potential health risks. Drinking BRJ may easily increase nitrate intake above the acceptable daily intake, which is known to stimulate the endogenous formation of N-nitroso compounds (NOC's), a class of compounds that is known to be carcinogenic and that may also induce several other adverse effects. Compared to studies on the beneficial effects, the amount of data and literature on the negative effects of BRJ is rather limited, and should be increased in order to perform a balanced risk assessment.

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“…Quando ingerido, o nitrato e o nitrito podem ser convertidos endogenamente em óxido nítrico (NO) e espécies nitrosiladas, como descrito nos próximos tópicos. Sugerindo assim que o nitrato e nitrito, presentes nos vegetais, tenham uma grande importância nos efeitos cardiovasculares da dieta vegetariana (Raubenheimer et al 2017). …”

Section: Dietas Ricas Em Vegetais E Sua Importância Na Prevenção De Dunclassified

Efeitos de drogas inibidoras da secreção ácida do estômago sobre as respostas hipotensoras do nitrito de sódio

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Acute Effects of Nitrate-Rich Beetroot Juice on Blood Pressure, Hemostasis and Vascular Inflammation Markers in Healthy Older Adults: A Randomized, Placebo-Controlled Crossover Study

Cited by 63 publications

References 37 publications

Inflammation as a mediator of arterial ageing

Inflammation as a mediator of arterial ageing

The benefits and risks of beetroot juice consumption: a systematic review

Efeitos de drogas inibidoras da secreção ácida do estômago sobre as respostas hipotensoras do nitrito de sódio

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