Acute Effects of Nicotine and Smoking on Blood Flow, Tissue Oxygen, and Aerobe Metabolism of the Skin and Subcutis

Sørensen, Lars Tue; Jørgensen, Solvejg; Petersen, Lone; Hemmingsen, Ulla; Bülow, Jens; Loft, Steffen; Gottrup, Finn

doi:10.1016/j.jss.2008.02.066

Cited by 188 publications

(129 citation statements)

References 47 publications

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“…Amongst over 4000 substances detected in tobacco smoke, several ones negatively impact healing processes [56]. To this end, nicotine strongly promotes vasoconstriction leading to disturbed microcirculation that negatively impacts WH [56,57]. Further, smoking attenuates the inflammation phase by impairing white blood cell migration, reducing neutrophil bactericidal activity, and depressing IL-1 production [56,58].…”

Section: Smoking Strongly Impairs Wound Healingmentioning

confidence: 99%

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

Avishai¹,

2017

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Whereas the physiologic wound healing (WH) successfully proceeds through the clearly defined sequence of the individual phases of wound healing, chronic non-healing wounds/ulcers fail to complete the individual stages and the entire healing process. There are many risk factors both modifiable (such as stress, smoking, inappropriate alcohol consumption, malnutrition, obesity, diabetes, cardio-vascular disease, etc.) and non-modifiable (such as genetic diseases and ageing) strongly contributing to the impaired WH. Current statistics demonstrate that both categories are increasingly presented in the populations, which causes dramatic socio-economic burden to the healthcare sector and society at large. Consequently, innovative concepts by predictive, preventive and personalised medicine are crucial to be implemented in the area. Individual risk factors, causality, functional interrelationships, molecular signature, predictive diagnosis, and primary and secondary prevention are thoroughly analysed followed by the expert recommendations in this paper.

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Section: Smoking Strongly Impairs Wound Healingmentioning

confidence: 99%

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

Avishai¹,

2017

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“…In a study made by Rodriguez-Argueta et al [20], they discussed how the cigarette components affected the bone vascularization, the nicotine is a potent vasoconstrictor that reduces blood flow and nutrient delivery to healing sites, causing tissue glucose reduction and acidosis. The carbon monoxide also reduces the oxygen-carrying capacity of erythrocytes, and hydrogen cyanide causes tissue hypoxia [20,24,27]. Additionally, the very poor systemic health did not allow an adequate treatment and she did not respond to several attempts.…”

Section: Discussionmentioning

confidence: 99%

Jaw osteonecrosis after dental implants associated with oral bisphosphonates – case report of resection of mandible

Corso

Todero

Sebastiani

et al. 2017

RSBO

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Osteonecrosis of the jaw is associated with defects in vascularization and with the use of oral bisphosphonates. Osseous exposition and infection may occur. Recommended treatment is variable, from antibiotic medication, bony decortication to resections of the mandible in severe cases. Reconstruction of mandible, in cases of resections is essential for maintaining esthetic profile and adequate form and function. Objective: To report a case about the dangers oforal bisphosphonates in association with invasive procedures such as dental implants Case report: Female patient, 64 years-old, with osteonecrosis of the jaw caused by use of oral bisphosphonates after rehabilitation with dental implants. She had an edentulous and atrophic mandible and poor healthy. After diagnosis, partial resection of the jaw was performed together with the reconstruction with titanium plate, with no success. Then, iliac bone graft fixed by plates and screws was attempted, again with no success. Conclusion: Despiteof the small number of cases of osteonecrosis associated with oral bisphosphonate reported in the literature, a simple implant surgery could result in adverse consequences if the use of this medication were overlooked in the anamnesis.

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“…Nicotine has vasoactive effects, decreasing blood flow, and consequently the amount of oxygen in the tissues [16]. Alcohol drinking is often associated with bad health habits and self-care, damaging the wound closure.…”

Section: Sociodemographic Clinical and Care Influence In The Healinmentioning

confidence: 99%

Aspects Related to Venous Ulcer Healing and its Influence on Quality of Life

Torres¹,

Mansano-Scholosser²,

Araújo³

et al. 2016

Worldwide Wound Healing - Innovation in Natural and Conventional Methods

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Nowadays, the varicose ulcers (VUs) are one of the most worrying leg ulcers and are an important global health problem, with high costs related to the treatment and its complications. Moreover, the quality of life (QOL) of the patient could be affected by pain, sleep disorders, functional impairment, depression, and isolation. The VU patient care is complex, and it is necessary to know the aspects that contribute to the healing process for developing effective strategies. The members of the multidisciplinary health team should identify sociodemographic, clinical, and care aspects that interfere in tissue repair and therefore impacting the QOL. Self-efficacy, adherence to treatment, and self-esteem are other important aspects also related to healing and QOL, with implications for health care and the multidisciplinary team. To sum up, the use of multidisciplinary protocols allows the systematization of care for people with VUs in order to standardize therapeutic interventions with the aim to decrease the healing process time and, as a consequence, to improve the QOL.

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Acute Effects of Nicotine and Smoking on Blood Flow, Tissue Oxygen, and Aerobe Metabolism of the Skin and Subcutis

Cited by 188 publications

References 47 publications

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

Jaw osteonecrosis after dental implants associated with oral bisphosphonates – case report of resection of mandible

Aspects Related to Venous Ulcer Healing and its Influence on Quality of Life

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