Acute effects of milk polar lipids on intestinal tight junction expression: towards an impact of sphingomyelin through the regulation of IL-8 secretion?

Milard, Marine; Penhoat, Armelle; Durand, Annie; Buisson, C.; Loizon, Emmanuelle; Meugnier, Emmanuelle; Bertrand, Karène; Joffre, Florent; Cheillan, David; Garnier, L.; Viel, Sébastien; Laugerette, Fabienne; Michalski, Marie‐Caroline

doi:10.1016/j.jnutbio.2018.12.007

Cited by 27 publications

(14 citation statements)

References 69 publications

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“…MFGM and MFGM components can promote the formation of tight junctions, which result in the integrity of intestinal mucosal barrier. [ 22,43 ] In a previous study, no significant difference was observed regarding staining intensity of Claudin‐3 and Claudin‐4 in ileum between breast‐fed and infant‐formula‐fed pups. [ 23 ] In contrast, infant formula feeding decreased Claudin‐3 and Claudin‐4 expression compared to breast‐fed pups in our study, which was attributed to differences in the composition of infant formula.…”

Section: Discussionmentioning

confidence: 96%

Dietary Milk Fat Globule Membrane Restores Decreased Intestinal Mucosal Barrier Development and Alterations of Intestinal Flora in Infant‐Formula‐Fed Rat Pups

Gong

Yuan

Pang³

et al. 2020

Molecular Nutrition Food Res

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Scope: Milk fat globule membrane (MFGM), which contains abundant polar lipids and glycoproteins, can narrow the gap in growth and development between breast-fed and infant-formula-fed babies. The objective of this study is to evaluate the effect of MFGM supplementation in infant formula on intestinal epithelium maturation, tight junctions, and gut colonization in rat pups. Methods and results: Sprague Dawley rat pups consume one of the five diets from postnatal day 8, including rat breastfeeding (BF), infant formula (IF), and infant formula containing MFGM at 260 mg kg −1 body weight (BW), 520 mg kg −1 BW, or 1040 mg kg −1 BW. Results show that MFGM supplementation in infant formula can facilitate intestinal mucosal barrier maturation via promoting intestinal proliferation and differentiation, and increasing tight junction proteins. In addition, compared with that of the IF pups, the intestinal flora composition of MFGM-supplemented pups is more similar to that of BF pups. Conclusion: MFGM supplementation in infant formula can restore the intestinal development in infant-formula-fed pups, which suggests that the supplementation of MFGM in infant formula can better mimic breast milk.

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Section: Discussionmentioning

confidence: 96%

Dietary Milk Fat Globule Membrane Restores Decreased Intestinal Mucosal Barrier Development and Alterations of Intestinal Flora in Infant‐Formula‐Fed Rat Pups

Gong

Yuan

Pang³

et al. 2020

Molecular Nutrition Food Res

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“…The answer can be found in the literature data that demonstrate the importance of this lipid for the intestine health and for the maturation of the nervous system. In 2019 Milard et al [ 33 ] showed the milk SM beneficial effects on intestinal functions through the stimulation of the intestinal tight junction expression mediated by IL-8. Norris et al [ 34 ] described the protective properties of milk SM against dysfunctional lipid metabolism, gut dysbiosis, and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Human breast milk as source of sphingolipids for newborns: comparison with infant formulas and commercial cow’s milk

et al. 2020

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Background In the past two decades, sphingolipids have become increasingly appreciated as bioactive molecules playing important roles in a wide array of pathophysiology mechanisms. Despite advances in the field, sphingolipids as nutrients remain little explored. Today the research is starting to move towards the study of the sphingomyelin content in human breast milk, recommended for feeding infants. Methods In the present study, we performed a lipidomic analysis in human breast milk in relation with maternal diet during pregnancy, in infant formulas, and in commercial whole and semi-skimmed milks for adults. Mediterranean, carnivorous and vegetarian diets were considered. Results The results showed that total sphingomyelin, ceramide and dihydroceramide species are independent on the diet. Interestingly, the milk sphingolipid composition is species-specific. In fact, infant formulas and commercial milks for adults have a lower level of total sphingomyelin and ceramide content than human breast milk with very different composition of each sphingolipid species. Conclusions We conclude that human breast milk is a better source of sphingolipids than infant formulas for baby nutrition with potential implications for the brain development and cognitive functions.

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“…Endotoxemia is a persistent sub-clinical, low-grade inflammation due to circulating endotoxins, primarily LPS, which may be absorbed into circulation due to defects in the gut barrier. Milard et al [81] observed gut barrier effects when Caco-2/TC7 cells were treated with milk SM incorporated into mixed micelles. They observed significant inductions in the gene expression of tight junction proteins, which was related to a specific induction of interleukin-8 (IL-8) by milk SM.…”

Section: Anti-inflammatory Effectsmentioning

confidence: 99%

Milk Polar Lipids: Underappreciated Lipids with Emerging Health Benefits

et al. 2020

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Milk fat is encased in a polar lipid-containing tri-layer milk fat globule membrane (MFGM), composed of phospholipids (PLs) and sphingolipids (SLs). Milk PLs and SLs comprise about 1% of total milk lipids. The surfactant properties of PLs are important for dairy products; however, dairy products vary considerably in their polar lipid to total lipid content due to the existence of dairy foods with different fat content. Recent basic science and clinical research examining food sources and health effects of milk polar lipids suggest they may beneficially influence dysfunctional lipid metabolism, gut dysbiosis, inflammation, cardiovascular disease, gut health, and neurodevelopment. However, more research is warranted in clinical studies to confirm these effects in humans. Overall, there are a number of potential effects of consuming milk polar lipids, and they should be considered as food matrix factors that may directly confer health benefits and/or impact effects of other dietary lipids, with implications for full-fat vs. reduced-fat dairy.

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Acute effects of milk polar lipids on intestinal tight junction expression: towards an impact of sphingomyelin through the regulation of IL-8 secretion?

Cited by 27 publications

References 69 publications

Dietary Milk Fat Globule Membrane Restores Decreased Intestinal Mucosal Barrier Development and Alterations of Intestinal Flora in Infant‐Formula‐Fed Rat Pups

Dietary Milk Fat Globule Membrane Restores Decreased Intestinal Mucosal Barrier Development and Alterations of Intestinal Flora in Infant‐Formula‐Fed Rat Pups

Human breast milk as source of sphingolipids for newborns: comparison with infant formulas and commercial cow’s milk

Milk Polar Lipids: Underappreciated Lipids with Emerging Health Benefits

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