Acute effects of marathon running on levels of serum lipoproteins and androgenic hormones in healthy males

Kuusi, Timo; Kostiainen, Ella; Vartiainen, Erkki; Pitkänen, Lahja; Ehnholm, Christian; Korhonen, Heikki; Nissinen, Aulikki; Puska, Pekka

doi:10.1016/0026-0495(84)90007-6

Cited by 51 publications

(24 citation statements)

References 29 publications

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“…Other approaches to studying apo A-I in exercisers have yielded less consistent results than cross-sectional studies. Studies on acute effects show that apo A-I may [22] or may not increase [23,24] after extended bouts of exercise. Some training studies show an increase in apo A-I [25], whereas others show no change [26][27][28][29].…”

Section: Discussion Apo A-i and A-iimentioning

confidence: 99%

Effects of weight-loss by exercise and by diet on apolipoproteins A-I and A-II and the particle-size distribution of high-density lipoproteins in men

Williams¹,

Krauss²,

Vranizan³

et al. 1992

Metabolism

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We studied separately the effects of weight-loss by dieting or by running on apolipoprotein (apo) A-I, apo A-II, and high-density lipoprotein (HDL) subfractions in sedentary, moderately overweight men assigned at random into three groups: exercise without calorie restriction, calorie restriction without exercise, and control. The absorbance of protein-stained polyacrylamide gradient gels was used as an index of mass concentrations for five HDL subclasses that have been identified by their particle sizes: HDL 3c (7.2 to 7.8 nm), HDL 3b (7.8 to 8.2 nm), HDL 3a (8.2 to 8.8 nm), HDL 2a (8.8 to 9.7 nm), and HDL 2b (9.7 to 12.8 nm). During the l-year trial, the exercisers ran (mean ± SD) 15.8 ± 8.1 km/wk, and the dieters reported eating 340±71 fewer calories per day than at baseline. Total body weight and fat weight were both reduced significantly more in dieters (−7.2 ± 4.1 and −6.2 ± 4.1 kg, respectively) and in exercisers (−4.0 ± 3.9 and −4.6 ± 3.5 kg) than in controls (0.6 ± 3.7 and −0.7 ± 2.7 kg). As compared with mean changes in controls, exercisers and dieters each decreased HDL 3b and increased HDL 2b . Exercisers also significantly increased plasma apo A-I concentrations. Analysis of covariance was used to statistically adjust the mean lipoprotein changes for the effects of weight-loss. The adjustment eliminated the significant reductions in HDL 3b and the significant increases in HDL 2b in exercisers and dieters, and it eliminated the significant increase in apo A-I in exercisers. When adjusted, the dieters' mean changes in HDL 2b had significantly decreased relative to those of both exercisers and controls. These results suggest that the changes in HDL 3b , HDL 2b , and apo A-I during 12 months of exercise could be due to metabolic changes associated with exerciseinduced weight-loss. Reduced calorie flux or other factors appear to attenuate the increase in HDL 2b and apo A-I during diet-induced weight-loss.Running increases the plasma mass and cholesterol concentrations of high-density lipoprotein (HDL) 2 in men [1][2][3]. The HDL 3 response to running is less clear, with some studies showing an increase and other studies showing either a decrease or no change [1,2,4]. HDLs may be further divided into two HDL 2 and three HDL 3 subclasses by nondenaturing polyacrylamide gradient gel electrophoresis [5]. They are defined by their estimated particle diameters: HDL 3c (7.2 to 7.8 nm), HDL 3b (7.8 to 8.2 nm), HDL 3a (8.2 to 8.8 nm), HDL 2a (8.8 to 9.7 nm), and HDL 2b (9.7 to 12.9 nm) [5]. These HDL subclasses show relationships to other lipoprotein variables that suggest that HDL 2a and HDL 2b are inversely related, and HDL 3b is positively related to coronary heart disease risk [6]. To our knowledge, the effects of exercise or diet on HDL subclass measurements by gradient gel electrophoresis have not been previously reported. This report describes the effects of diet-induced weight-loss and exercise-induced weight-loss on plasma apolipoprotein (apo) A-I and apo A-II concentrations, and on protein-staine...

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Section: Discussion Apo A-i and A-iimentioning

confidence: 99%

Effects of weight-loss by exercise and by diet on apolipoproteins A-I and A-II and the particle-size distribution of high-density lipoproteins in men

Williams¹,

Krauss²,

Vranizan³

et al. 1992

Metabolism

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“…The gonadotrophin response to acute exercise in the male is also controversial (Sutton et al, 1973;Dessypris et al, 1976;Kuoppasalmi et al, 1976;Gawel et al, 1979;Grossman etaf., 1984;Kuusi et a/., 1984;Cumminget al, 1986). Testosterone rises during short-term exercise (Sutton et al, 1973;Kuoppasalmi et al, 1976;Gawel et al, 1979;Grossman et al, 1984) but then falls with more prolonged exertion such as marathon running or military training (Dessypris et al, 1976;Kuusi et al, 1984;Aakvaag & Opstad, 1985). This rise in testosterone seems to be simultaneous with any rise in LH, rather than following it, and may therefore not be mediated by gonadotrophin secretion (Cumming et al, 1986).…”

Section: Gonadotrophins and Gonadal Steroidsmentioning

confidence: 99%

Hormonal Responses to Exercise and Training: A Short Review

Howlett

1987

Clinical Endocrinology

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“…Testosterone production in the testes is primarily regulated by pituitary luteinising hormone (LH) produced in the pituitary. During marathon running and prolonged exercise, LH levels have been shown both to decrease4 11 and to remain unchanged 2 3 12 13. This discrepancy may be due to the pulsatile release of LH.…”

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confidence: 99%