Acute effects of lithium on dopaminergic responses: Iontophoretic studies in the rat visual cortex

Gottberg, Estela; Montreuil, Bernard; Reader, Tomás A.

doi:10.1002/syn.890020412

Cited by 30 publications

(7 citation statements)

References 29 publications

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“…The lack of DAergic effects upon local application is contrary to the inhibitory responses observed earlier [21,22]. Although DA can exert different actions depending on concentration [13], none of the DA concentrations used in this study changed the amplitude or SNR of the visually evoked responses.…”

Section: Neurophysiological Effects Of Da Injectioncontrasting

confidence: 67%

Dopamine-Induced Dissociation of BOLD and Neural Activity in Macaque Visual Cortex

et al. 2014

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Neuromodulators determine how neural circuits process information during cognitive states such as wakefulness, attention, learning, and memory. fMRI can provide insight into their function and dynamics, but their exact effect on BOLD responses remains unclear, limiting our ability to interpret the effects of changes in behavioral state using fMRI. Here, we investigated the effects of dopamine (DA) injections on neural responses and haemodynamic signals in macaque primary visual cortex (V1) using fMRI (7T) and intracortical electrophysiology. Aside from DA's involvement in diseases such as Parkinson's and schizophrenia, it also plays a role in visual perception. We mimicked DAergic neuromodulation by systemic injection of L-DOPA and Carbidopa (LDC) or by local application of DA in V1 and found that systemic application of LDC increased the signal-to-noise ratio (SNR) and amplitude of the visually evoked neural responses in V1. However, visually induced BOLD responses decreased, whereas cerebral blood flow (CBF) responses increased. This dissociation of BOLD and CBF suggests that dopamine increases energy metabolism by a disproportionate amount relative to the CBF response, causing the reduced BOLD response. Local application of DA in V1 had no effect on neural activity, suggesting that the dopaminergic effects are mediated by long-range interactions. The combination of BOLD-based and CBF-based fMRI can provide a signature of dopaminergic neuromodulation, indicating that the application of multimodal methods can improve our ability to distinguish sensory processing from neuromodulatory effects.

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Section: Neurophysiological Effects Of Da Injectioncontrasting

confidence: 67%

Dopamine-Induced Dissociation of BOLD and Neural Activity in Macaque Visual Cortex

et al. 2014

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“…It has been suggested that mesocortical dopaminergic inputs play a role in the mPFC and the sensory cortex (Bradshaw et al 1985;Gottberg et al 1988;Parkinson 1989;Reyes et al 2002). Dopaminergic fibers have been found in the AC (Campbell et al 1987;Harper and Wallace 1995;Goldsmith and Joyce 1996).…”

Section: Dopaminergic Inputs To the Ac Required For Sound Sequence DImentioning

confidence: 99%

Sound sequence discrimination learning motivated by reward requires dopaminergic D2 receptor activation in the rat auditory cortex

Kudoh¹,

Shibuki²

2006

Learn. Mem.

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We have previously reported that sound sequence discrimination learning requires cholinergic inputs to the auditory cortex (AC) in rats. In that study, reward was used for motivating discrimination behavior in rats. Therefore, dopaminergic inputs mediating reward signals may have an important role in the learning. We tested the possibility in the present study. Rats were trained to discriminate sequences of two sound components, and licking behavior in response to one of the two sequences was rewarded with water. To identify the dopaminergic inputs responsible for the learning, dopaminergic afferents to the AC were lesioned with local injection of 6-hydroxydopamine (6-OHDA). The injection attenuated sound sequence discrimination learning, while it had no effect on discrimination between the sound components of the sequence stimuli. Local injection of 6-OHDA into the nucleus accumbens attenuated sound discrimination learning. However, not only discrimination learning of sound sequence but also that of the sound components were impaired. SCH23390 (0.2 mg/kg, i.p.), a D1 receptor antagonist, had no effect on sound sequence discrimination learning, while it attenuated the licking behavior to unfamiliar stimuli. Haloperidol (0.5 mg/kg, i.p.), a D2 family antagonist, attenuated sound sequence discrimination learning, while it had no clear suppressive effect on discrimination of two different sound components and licking. These results suggest that D2 family receptors activated by dopaminergic inputs to the AC are required for sound sequence discrimination learning.

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“…In fact, lithium is affective in controlling dopamine stimulants related behaviours (Acquas and Fibiger, 1996;Barnes et al, 1986;Carli et al, 1997b;Dziedzicka-Wasyleweska et al, 1996;Goodwin and Jamison, 1990;Gottberg et al, 1988Gottberg et al, , 1989Post and Weiss, 1995;Richelson, 1995).…”

Section: Clinical Featuresmentioning

confidence: 94%

The role of mood stabilisers in the treatment of the depressive facet of bipolar disorders

Bourin

Prica

2007

Neuroscience & Biobehavioral Reviews

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Acute effects of lithium on dopaminergic responses: Iontophoretic studies in the rat visual cortex

Cited by 30 publications

References 29 publications

Dopamine-Induced Dissociation of BOLD and Neural Activity in Macaque Visual Cortex

Dopamine-Induced Dissociation of BOLD and Neural Activity in Macaque Visual Cortex

Sound sequence discrimination learning motivated by reward requires dopaminergic D2 receptor activation in the rat auditory cortex

The role of mood stabilisers in the treatment of the depressive facet of bipolar disorders

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