Acute effects of digitalis and enalapril on the neurohormonal profile of chagasic patients with severe congestive heart failure

Khoury, Antonio; Dávila, Diego F.; Bellabarba, Gabriela Arata de; Donis, José H.; Torres, Argenis; Lemorvan, Cecilia; Hernández, Luís E.; Bishop, Walter

doi:10.1016/s0167-5273(96)02776-3

Cited by 35 publications

(22 citation statements)

References 33 publications

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“…Although no long-term prospectively controlled study has been reported assessing the impact on survival of chagasic patients treated with ACE-inhibitors or any other pharmacological interventions, there is no reason to expect that their beneficial effect would be any different from that observed in heart failure due to other etiologies. In fact, there seems to be a favorable acute neuromodulating effect of ACE-inhibition in chagasic patients 174 .…”

Section: Management Of Chagas' Heart Diseasementioning

confidence: 99%

Chagas' heart disease

Marin-Neto¹,

Simões²,

Sarabanda³

1999

Arq. Bras. Cardiol.

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Section: Management Of Chagas' Heart Diseasementioning

confidence: 99%

Chagas' heart disease

Marin-Neto¹,

Simões²,

Sarabanda³

1999

Arq. Bras. Cardiol.

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“…Digitalis, angiotensin-converting enzyme inhibitors [19] and beta-blockers [20] have proven to be useful in reducing neurohormonal activation in patients with advanced Chagas cardiomyopathy.…”

Section: Discussionmentioning

confidence: 99%

Emerging and under-recognized Chagas cardiomyopathy in non-endemic countries

Cortez

Providência

Ramos

et al. 2012

WJC

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Due to recent population emigration movements, an epidemic of Chagas disease is currently menacing most developed countries. The authors report the case of a 53-year-old Brazilian woman living in Europe for the last 10 years who developed heart failure symptoms, having a previous symptomatic sinus node disease with a pacemaker implant at age of 40 years. The diagnosis was based on serology and myocardial biopsy and the patient was treated with nifurtimox. The authors emphasize the need of a high level of suspicion in patients with suggestive epidemiology and the need of populational screening of specific high risk groups. New treatment options are also discussed.

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“…These individuals are candidates for preventive treatment with angiotensin-converting enzyme inhibitors, which can delay the appearance of symptoms and reduce mortality in the presence of left ventricular dysfunction 17 . Although the beneficial effects of these drugs on the survival of patients with Chagas' heart disease have not been formally tested, their beneficial clinical and hemodynamic effects on patients with Chagas' heart disease are evident 18,19 . In addition, these drugs are indicated in all patients with left ventricular dysfunction, symptomatic or not, independent of its etiology 20 .…”

Section: Discussionmentioning

confidence: 99%