Acute effects of Benzo[a]pyrene, anthracene and a fuel oil on biomarkers of the common goby Pomatoschistus microps (Teleostei, Gobiidae)

Vieira, Luís R.; Sousa, Andreia S. P.; Frasco, Manuela F.; Lima, Inês; Morgado, Fernando; Guilhermino, Lúcia

doi:10.1016/j.scitotenv.2008.01.052

Cited by 135 publications

(54 citation statements)

References 75 publications

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“…Liu et al also reported that the group exposed to COEs had significantly increased levels of GST in the PAHs exposed individuals (Liu et al, 2006). The induction of GST by PAHs suggests that GSH conjugation is involved in PAHs removal (Gowland et al, 2002;Vieira et al, 2008). As we know, GST serves as a phase II enzyme in detoxifying xenobiotics and keeping intracellular redox balance in the presence of its substrates.…”

Section: Discussionmentioning

confidence: 93%

Synergistic Increase of Oxidative Stress and Tumor Markers in PAH-Exposed Workers

Gao

Chen²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 93%

Synergistic Increase of Oxidative Stress and Tumor Markers in PAH-Exposed Workers

Gao

Chen²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Quant à l'étude de la réponse des glutathion-S-transférases, il est connu que cette classe d'enzymes, impliquée dans les mécanismes de biotransformation de phase II, est induite en réponse à une contamination par les hydrocarbures aromatiques polycycliques (VIERA et al, 2008). Toutefois, dans ce présent travail, l'étude cinétique de la réponse des GST paraît peu significative vis-à-vis d'une contamination par le B(a)P, le Cd ainsi que leur mélange, et ceci, par comparaison aux niveaux d'induction chez les témoins relatifs.…”

Section: Discussionunclassified

Étude de l’effet du cadmium et du benzo[a]pyrène sur des enzymes de phase I et phase II de biotransformation chez le polychète Nereisdiversicolor

Bouraoui¹,

Ghedira²,

Jebali³

et al. 2009

rseau

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Le présent travail reporte l’effet du cadmium (Cd), du benzo[a]pyrène (B[a]P) ainsi que leur mélange (Cd/B[a]P), à 1 µM, sur les activités d’enzymes impliqués dans la phase I et la phase II de biotransformation chez le polychète Nereis diversicolor en fonction du temps (après 12, 24, 36 et 48 h).L’effet d’une contamination aiguë par du cadmium à une dose de 1 µM après 12, 24 et 36 h montre une inhibition de l’activité NADPH cytochrome C réductase chez les individus contaminés comparés à leurs témoins relatifs, alors que le seul effet du cadmium sur l’activité glutathion-S-transférase n’est enregistré qu’après 36 h d’exposition. Quant au benzo[a]pyrène, les résultats montrent une augmentation significative de l’activité NADPH cytochrome C réductase après 12, 24 et 36 h d’exposition, alors que pour l’activité glutathion-S‑transférase, la variation significative entre les animaux témoins et traités n’est enregistrée qu’à 36 h d’exposition. Le mélange (Cd/B[a]P) inhibe l’activité NADPH cytochrome C réductase chez les individus traités par comparaison aux témoins relatifs et montre un effet inducteur sur l’activité GST sauf après 36 h d’exposition. Ces résultats montrent ainsi les interactions entre les polluants ainsi que leurs effets sur les organismes.The acute effects of cadmium and benzo[a]pyrene, individually and as a mixture, were evaluated on the phase I and phase II biotransformation enzymes of Nereis diversicolor (Polychaeta) collected from unpolluted sites. In the acute assay (1 µM) after 12, 24, 36 and 48 h, the comparison between worms exposed to cadmium and their controls showed an inhibited activity of NADPH cytochrome C reductase after 12, 24 and 36 h. For the activity of glutathione-S-transferase (GST), however, inhibition in the presence of Cd was only noted after 36 h of exposure. Although exposure to benzo[a]pyrene resulted in a significant increase in NADPH cytochrome C reductase activity after 12, 24 and 36 h, a significant difference in glutathione-S-transferase (GST) activity between treated and control animals was only observed after 36 h. The mixture (Cd/B[a]P) seemed to inhibit the activity of NADPH cytochrome C reductase and to induce the activity of GST in individuals but only up until 36 h of exposure. These findings illustrate the interactions between pollutants and their effects on organisms

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“…SOD detoxifies superoxide radicals to hydrogen peroxide, CAT decomposes hydrogen peroxide to water and oxygen and GPx converts peroxides and hydroxyl radicals into non-toxic forms [35]. GSH constitutes the first line of defense against free radicals and plays an important role in Palanisamy and Samiappan the detoxification of electrophilic substances and prevention of cellular oxidative stress [36]. Several studies have shown that many radical scavengers, including naturally occurring compounds such as vitamin C, have been found to possess a strong antioxidant activity related to a strong scavenging capacity [37].…”

Section: Palanisamy and Samiappanmentioning

confidence: 99%

Antioxidant and Chemotherapeutic Potential of Curcuma Amada Rhizome Extract on Benzo(a)pyrene Induced Cervical Carcinoma in Sprague Dawley Rats

Devaraj

Samiappan²

2017

Asian J Pharm Clin Res

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Objective: To evaluate the antioxidant and chemotherapeutic potential of Curcuma amada Rhizome extract on benzo(a)pyrene (BaP) induced cervical carcinoma in Sprague Dawley rats.Methods: A total of 30 female Sprague Dawley rats were selected to establish cervical cancer model and then divided into 5 groups at random with six mice in each group. Group 1 control, Group 2 BaP (oral), Group 3 BaP for 8 weeks and post-treated with cisplatin (intravenous administration), Group 4 BaP for 8 weeks and post-treated with 250 mg of ethanol extract of C. amada (oral), Group 5 BaP for 8 weeks and post-treated with 500 mg of ethanol extract of C. amada (oral). 4 weeks after the treatment, the animals were sacrificed, serum separated, and cervical tissues were dissected. Antioxidants and the markers carcinoembryonic antigen (CEA), cancer antigens (CAs) 125, gamma glutamyltransferase (GTT) were assayed in serum and the tissue was used for analyzing tumor burden and sectioned for histopathological assays.10% tissue homogenate was estimated for antioxidants and membrane-bound enzymes.Results: BaP treated group showed significant (p<0.001) incidence of tumor burden, decreased activities of antioxidants, elevated lipid peroxidation, Na Conclusion:From the results, it can be concluded that C. amada Rhizome extract ameliorated BaP induced oxidative stress in the cervical carcinogenicity of rats.

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Acute effects of Benzo[a]pyrene, anthracene and a fuel oil on biomarkers of the common goby Pomatoschistus microps (Teleostei, Gobiidae)

Cited by 135 publications

References 75 publications

Synergistic Increase of Oxidative Stress and Tumor Markers in PAH-Exposed Workers

Synergistic Increase of Oxidative Stress and Tumor Markers in PAH-Exposed Workers

Étude de l’effet du cadmium et du benzo[a]pyrène sur des enzymes de phase I et phase II de biotransformation chez le polychète Nereisdiversicolor

Antioxidant and Chemotherapeutic Potential of Curcuma Amada Rhizome Extract on Benzo(a)pyrene Induced Cervical Carcinoma in Sprague Dawley Rats

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