Acute effects of aqueous leaf extract of &lt;i&gt;Aspilia Africana&lt;/i&gt; C.D. adams on some haematological parameters in rats

Ajeigbe, K.O.; Enitan, Seyi Samson; Omotoso, Dayo Rotimi; Oladokun, Olayemi Olutobi

doi:10.4314/ajtcam.v10i5.4

Cited by 15 publications

(18 citation statements)

References 19 publications

(10 reference statements)

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“…This is consistent with the finding of an earlier study in which Aspilia africana aqueous extract stimulated white blood cell proliferation. 34 The rise in white blood cell count in the present investigation may not necessarily be attributed to the presence of infection but may have been triggered by the method of blood collection or by stress factors induced by oral intake of the extracts. 35,36 The effects of the aqueous extract on renal parameters when compared to the chloroform extract suggest that the components in Aspilia africana that influenced kidney function are likely polar in nature.…”

Section: Resultsmentioning

confidence: 60%

“…33 In contrast, it has previously been reported that at higher doses (250 -500 mg/kg body weight), the aqueous extract of Aspilia africana stimulated erythropoiesis. 34 Mean corpuscular volume was not significantly different (p>0.05) among the groups, an indication that the plant did not induce significant alterations in blood cell volume. In addition, packed cell volume of blood was not significantly different (p>0.05) ( Table 2).…”

Section: Resultsmentioning

confidence: 88%

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Untitled

2019

TJNPR

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Medicinal plants as sources of bioactive agents continue to exhibit fascinating ability in terms of human health management since ancient times with more than half of modern therapeutics in circulation being of natural product origin. 1 The vital role of medicinal herbs in the treatment and prevention of diseases is not by itself an assurance of safety if not properly used by an uninformed public. 2 Aspilia Africana, is a tropical, semi-woody perennial herb belonging to the family, asteracea. It is used by traditional communities in Africa and Asia as a bactericidal, anti-inflammatory, astringent and wound-healing agent. 3,4 Oral consumption of the decoction of the leaves is reportedly able to relieve febrile headache, quicken delivery and cure lumbago, sciatica and stomach disorders. 5-7 Besides management of stomach disorder, others have reported that in folklore medical practice, Aspilia africana herbal preparations can be used for the treatment of stomach aches, dysmenorrhoea, tuberculosis, rheumatoid arthritis, gonococal infection, corneal opacity, cough and insect bites. 8 The kidney performs functions

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Section: Resultsmentioning

confidence: 60%

Section: Resultsmentioning

confidence: 88%

Untitled

2019

TJNPR

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“…35 Significant lowering of WBC counts found after treatment with the medicines could be due to their toxic effects. This also suggests their potential to affect the immune system adversely by reducing the ability to decrease inflammation, fight off invading infections and diseases, 35 , 36 especially if taken over a prolonged period. Decreases in the hematological parameters by KT and KBA also suggest that intake of these medicines may result in anemia.…”

Section: Discussionmentioning

confidence: 99%

“…Decreases in the hematological parameters by KT and KBA also suggest that intake of these medicines may result in anemia. 36 …”

Section: Discussionmentioning

confidence: 99%

In Vivo Modulation of Rat Liver Microsomal Cytochrome P450 Activity by Antimalarial, Anti-HIV, and Antituberculosis Plant Medicines

Appiah–Opong

Tuffour

Ofori-Attah

et al. 2018

J Evid Based Complementary Altern Med

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Drug interactions are key reasons for adverse drug reactions and attrition from market. Major infectious diseases causing morbidity/mortality in Ghana are malaria, tuberculosis, and HIV/AIDS. In this study, plant medicines commonly used to treat/manage these diseases in Ghana were investigated for their potential to modulate rat cytochrome P450 enzyme activities. Fluorescence and high-performance liquid chromatography–based assays were used to assess effects of antimalarial plant medicines, Fever (FEV), Mal-TF (MAL), and Kantinka terric (KT); anti-TB medicines, Chestico (CHES), CA + ST Pains + HWNT (TF), and Kantinka herbatic (KHB); and anti-HIV/AIDS medicines, Wabco (WAB), AD + T/AD (LIV) and Kantinka BA (KBA) on rat liver microsomal cytochrome P450 enzyme activities. Effects of medicines on rat biochemical and hematological parameters were also assessed. Generally, the medicines altered microsomal CYP1A1/1A2, CYP2B1/2B2, CYP2C9, and CYP2D6 activities. Only KBA elicited an increase (80%) in CYP1A1/1A2 activity. FEV, MAL, CHES, WAB, and LIV strongly inhibited the enzyme activity. All the medicines significantly inhibited CYP2C9 (24%-80%) activity. CYP2D6 activity increased after treatment with MAL, KBA, LIV, and TF. Also, MAL, WAB, LIV, KHB, and CHES increased CYP2B1/2B2 activity, while KT decrease the activity. Generally, the medicines altered liver function in the rats. Cholesterol levels declined after KBA treatment only. White and red blood cell counts, hemoglobin and hematocrit levels were significantly reduced in KT- and KBA-treated rats. Our results suggest that use of the medicines could have implications for drug interactions and safety, particularly if the medicines are administered over prolonged periods. Further investigations are imperative to establish clinical relevance of these results.

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“…Indomethacin was dissolved in 5% sodium bicarbonate solution (Na2HCO3) to create a clear solution. The dose of Indo was selected from published literature according to Ajeigbe et al, (2014). Indomethacin (Liometacen) is the most favored drug to generate an experimental ulcer model because its potential to make ulcer is higher than other NSAIDs.…”

Section: Experimental Designmentioning

confidence: 99%

Anti-ulcer Activity of Avocado Juice and Kiwi Juice on Indomethacin Induced Gastric Ulcer in Rats

allah

Amira²

2019

Egyptian Journal of Nutrition and Health

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Over past decades, physicians have recommended dietary adjustments, aimed at preventing or treating symptoms of peptic ulcer, as a diet that moderates the risk of stomach ulceration. This study aims to investigate the effect and mechanism of consumption of avocado (Persea americana Mill) juice and kiwi (Actinidia deliciosa) juice to alleviate peptic ulcer in rats. Thirty-six male albino rats (185±10 g), were used and divided into 6 equal groups, one was kept as a (-ve) control group, while the other groups were received daily oral dose of indomethacin (25mg / kg b.Wt.) once daily for 21 days. One group received Indo only (+ve control group), while the other groups given orally (1.5, 3 ml per day) of each juice for 21 days plus Indo. Peptic ulcer index, preventive index, and acidity of gastric juice were assessed. Nitric oxide (NO), malondialdehyde (MDA) and glutathione (GSH) were measured in gastric tissue, as well as histopathological changes in the gastric mucosa. Treatment with avocado juice and kiwi juice resulted in amelioration of the gastric histological lesions induced by Indo. Moreover, fresh juices of avocado and kiwi significantly modulated biochemical marker of oxidative/nitrosative stress markers; malondialdehyde (MDA), and nitric oxide (NO) and antioxidant enzymes as glutathione (GSH), which were significantly disrupted in animal treated with Indo alone. According to this study, the fresh juices of avocado and kiwi could protect against peptic ulcer and its other side effects. This may be due to the high content of phenolic and flavonoid compounds in these juices.

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Acute effects of aqueous leaf extract of <i>Aspilia Africana</i> C.D. adams on some haematological parameters in rats

Cited by 15 publications

References 19 publications

Untitled

Untitled

In Vivo Modulation of Rat Liver Microsomal Cytochrome P450 Activity by Antimalarial, Anti-HIV, and Antituberculosis Plant Medicines

Anti-ulcer Activity of Avocado Juice and Kiwi Juice on Indomethacin Induced Gastric Ulcer in Rats

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