Acute effects of ambient nitrogen dioxide exposure on serum biomarkers of nervous system damage in healthy older adults

Song, Jie; Qu, Rongrong; Sun, Baoshan; Wang, Yinbiao; Chen, Renjie; Kan, Haidong; An, Zhen; Wu, Hui; Li, Juan; Jiang, Jing; Zhang, Yange; Wu, Weidong

doi:10.1016/j.ecoenv.2022.114423

Cited by 6 publications

(4 citation statements)

References 74 publications

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“…For example, there is some evidence that NO 2 preferentially affects females – increases in NO 2 have been associated with elevated serum protein gene product 9.5 (PGP9.5) in women, but decreased in men. 55 Because PGP9.5 originates in the brain, elevated serum PGP9.5 may indicate a compromised blood-brain barrier, implying that increased exposure to ambient NO 2 and subsequent oxidative stress may compromise the permeability of the blood-brain barrier. Females also may be at an increased risk of functional impairment from NO 2 .…”

Section: Discussionmentioning

confidence: 99%

Sex-specific effects in how childhood exposures to multiple ambient air pollutants affect white matter microstructure development across early adolescence

Cotter,

Ahmadi,

Cardenas-Iniguez

et al. 2023

Preprint

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Ambient air pollution is ubiquitous, yet questions remain as to how it might impact the developing brain. Large changes occur in the brain’s white matter (WM) microstructure across adolescence, with noticeable differences in WM integrity in male and female youth. Here we report sex-stratified effects of fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3) on longitudinal patterns of WM microstructure from 9-13 years-old in 8,182 (49% female) participants using restriction spectrum imaging. After adjusting for key sociodemographic factors, multi-pollutant, sex-stratified models showed that one-year annual exposure to PM2.5 and NO2 was associated with higher, while O3 was associated with lower, intracellular diffusion at age 9. All three pollutants also affected trajectories of WM maturation from 9-13 years-old, with some sex-specific differences in the number and anatomical locations of tracts showing altered trajectories of intracellular diffusion. Concentrations were well-below current U.S. standards, suggesting exposure to these criteria pollutants during adolescence may have long-term consequences on brain development.

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Section: Discussionmentioning

confidence: 99%

Sex-specific effects in how childhood exposures to multiple ambient air pollutants affect white matter microstructure development across early adolescence

Cotter,

Ahmadi,

Cardenas-Iniguez

et al. 2023

Preprint

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“…Longitudinal studies addressing ambient air exposure found that PM2.5 during pregnancy was associated with lower total BDNF levels in newborns ( Saenen et al, 2015 ; Wang et al, 2023 ), whereas cross-sectional studies focused on the old adult population (>60 years) found that NO 2 was associated with higher serum BDNF levels ( Song et al, 2022 ; Song et al, 2023 ). Exposure to PM1 and NO 2 in older healthy adults was cross-sectionally associated with higher DNA methylation of the BDNF gene ( Huang et al, 2022 ).…”

Section: Bdnf a Molecular Marker Of Brain Developmentmentioning

confidence: 99%

Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs

Rodríguez-Carrillo,

Verheyen,

Van Nuijs

et al. 2024

Front. Toxicol.

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The present narrative review summarizes recent findings focusing on the role of brain-derived neurotrophic factor (BDNF) as a biomarker of effect for neurodevelopmental alterations during adolescence, based on health effects of exposure to environmental chemical pollutants. To this end, information was gathered from the PubMed database and the results obtained in the European project Human Biomonitoring for Europe (HBM4EU), in which BDNF was measured at two levels of biological organization: total BDNF protein (serum) and BDNF gene DNA methylation (whole blood) levels. The obtained information is organized as follows. First, human biomonitoring, biomarkers of effect and the current state of the art on neurodevelopmental alterations in the population are presented. Second, BDNF secretion and mechanisms of action are briefly explained. Third, previous studies using BDNF as an effect biomarker were consulted in PubMed database and summarized. Finally, the impact of bisphenol A (BPA), metals, and non-persistent pesticide metabolites on BDNF secretion patterns and its mediation role with behavioral outcomes are addressed and discussed. These findings were obtained from three pilot studies conducted in HBM4EU project. Published findings suggested that exposure to some chemical pollutants such as fine particle matter (PM), PFAS, heavy metals, bisphenols, and non-persistent pesticides may alter circulating BDNF levels in healthy population. Therefore, BDNF could be used as a valuable effect biomarker to investigate developmental neurotoxicity of some chemical pollutants.

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“…Reactive nitrogen oxides (NO x ), which is a sum of nitrogen dioxide (NO 2 ) and nitrogen monoxide (NO), are one of the most important trace gases in a polluted atmosphere. NO x has been widely known to have direct health effects (Jo et al, 2021;Kampa and Castanas, 2008;Song et al, 2023) and plays an essential role in secondary ozone (O 3 ) and aerosol formation (Chan et al, 2010;Seinfeld and Pandis, 2016;Sillman, 1999), both of which are also the major atmospheric pollutants. NO x can be emitted from natural sources such as wildfires or lightning (Jaffe and Wigder, 2012;Stark et al, 1996), whereas anthropogenic emissions, mainly from the combustion of fossil fuels, are the main cause of the air quality deterioration in populated urban and industrial regions (Kim et al, 2013;Lamsal et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Airborne observation with a low-cost hyperspectral instrument: retrieval of NO₂ vertical column densities (VCDs) and the satellite sub-grid variability over industrial point sources

Park,

Kim,

Park

et al. 2024

Atmos. Meas. Tech.

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Abstract. High-spatial-resolution NO2 vertical column densities (VCDs) were retrieved from airborne observations using the low-cost hyperspectral imaging sensor (HIS) at three industrial areas (i.e., Chungnam, Jecheon, and Pohang) in South Korea, where point sources (i.e., power plant, petrochemical complex, steel yard, and cement kiln) with significant NO2 emissions are located. An innovative and versatile approach for NO2 VCD retrieval, hereafter referred to as the modified wavelength pair (MWP) method, was developed to overcome the excessively variable radiometric and spectral characteristics of the HIS attributed to the absence of temperature control during the flight. The newly developed MWP method was designed to be insensitive to broadband spectral features, including the spectral dependency of surface and aerosol reflectivity, and can be applied to observations with relatively low spectral resolutions. Moreover, the MWP method can be implemented without requiring precise radiometric calibration of the instrument (i.e., HIS) by utilizing clean-pixel data for non-uniformity corrections and is also less sensitive to the optical properties of the instrument and offers computational cost competitiveness. In the experimental flights using the HIS, NO2 plumes emitted from steel yards were particularly conspicuous among the various NO2 point sources, with peak NO2 VCDs of 2.0 DU (Dobson unit) at Chungnam and 1.8 DU at Pohang. Typical NO2 VCD uncertainties ranged between 0.025–0.075 DU over the land surface and 0.10–0.15 DU over the ocean surface, and the discrepancy can be attributable to the lower signal-to-noise ratio over the ocean and higher sensitivity of the MWP method to surface reflectance uncertainties under low-albedo conditions. The NO2 VCDs retrieved from the HIS with the MWP method showed a good correlation with the collocated Tropospheric Monitoring Instrument (TROPOMI) data (r=0.73, mean absolute error equals 0.106 DU). However, the temporal disparities between the HIS frames and the TROPOMI overpass, their spatial mismatch, and their different observation geometries could limit the correlation. The comparison of TROPOMI and HIS NO2 VCDs further demonstrated that the satellite sub-grid variability could be intensified near the point sources, with more than a 3-fold increase in HIS NO2 VCD variability (e.g., difference between 25th and 75th quantiles) over the TROPOMI footprints with NO2 VCD values exceeding 0.8 DU compared to footprints with NO2 VCD values below 0.6 DU.

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Acute effects of ambient nitrogen dioxide exposure on serum biomarkers of nervous system damage in healthy older adults

Cited by 6 publications

References 74 publications

Sex-specific effects in how childhood exposures to multiple ambient air pollutants affect white matter microstructure development across early adolescence

Sex-specific effects in how childhood exposures to multiple ambient air pollutants affect white matter microstructure development across early adolescence

Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs

Airborne observation with a low-cost hyperspectral instrument: retrieval of NO₂ vertical column densities (VCDs) and the satellite sub-grid variability over industrial point sources

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Acute effects of ambient nitrogen dioxide exposure on serum biomarkers of nervous system damage in healthy older adults

Cited by 6 publications

References 74 publications

Sex-specific effects in how childhood exposures to multiple ambient air pollutants affect white matter microstructure development across early adolescence

Sex-specific effects in how childhood exposures to multiple ambient air pollutants affect white matter microstructure development across early adolescence

Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs

Airborne observation with a low-cost hyperspectral instrument: retrieval of NO2 vertical column densities (VCDs) and the satellite sub-grid variability over industrial point sources

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Airborne observation with a low-cost hyperspectral instrument: retrieval of NO₂ vertical column densities (VCDs) and the satellite sub-grid variability over industrial point sources