Acute effects of ambient air pollution on lower respiratory infections in Hanoi children: An eight-year time series study

Nhung, Nguyễn Thị Trang; Schindler, Christian; Dien, Tran Minh; Probst‐Hensch, Nicole; Pérez, Laura; Künzli, Nino

doi:10.1016/j.envint.2017.10.024

Cited by 166 publications

(125 citation statements)

References 32 publications

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“…PM 2.5 , PM 1 are health-damaging particles not only because of their chemical components but because they can penetrate deep inside the lungs to aggravate existing asthma or to contribute to the development of chronic bronchitis (20,(49)(50)(51). Our meta-analyses showed wheeze-associated disorders were most strongly associated with PM 1 , which was consistent with the limited literature available on fine particles (46,52,53). Earlier evidence indicated that the small particles can reach bronchioles and penetrate up to the primary, secondary terminal bronchi, and alveoli in the lung which may trigger mucous secretions in airways, reduce air flow and then cause wheezing (54,55).…”

Section: Discussionsupporting

confidence: 87%

“…Based on the data in Table 1, nearly 84,000 pediatric wheeze-associated disorders events have been investigated to assess the impact of ambient air pollution in five countries. Of these, four studies were conducted in Thailand (7,(41)(42)(43), three in Vietnam (44)(45)(46), and one each in Singapore, Indonesia and Malaysia (8,9,47).…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies reported the effects of PM 10 (7, 8, 41-44, 46, 47), three reported the effects of PM 2.5 (41,43,46), four studies reported the effects of SO 2 (9,43,44,46), five studies reported the effects of NO 2 (8,9,44,46,47), three reported the effects of CO (8,46,47) and four reported the effects of O 3 (44)(45)(46)(47). Only one study reported the effects of TSP, PM 1 and NO x but Nhung et al (46) presented three estimates for PM 1 and NO x while only one estimate for TSP was given by Chew et al (9), therefore the effects of TSP were analyzed further. The daily mean concentrations of pollutants across all studies were 68.2 μg/m 3 for PM 10 , 45.8 μg/m 3 for PM 2.5 , 27.7 μg/m 3 for SO 2 , 33.5 μg/m 3 for NO 2 and 2479 μg/m 3 for CO and 81.1 μg/m 3 for O 3 (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Four studies investigated the association of air pollution with hospital admissions for wheeze-associated disorders, four explored rate the ratio of incidence or prevalence and the rest considered emergency room visits or mortality (Table 1). Five studies defined the outcome using the International Classification of Diseases (ICD) version 9 or 10 (9,42,(44)(45)(46), one based on the hospital admission data (47) and four used questionnaires for wheezing symptoms (7,8,41,43).…”

Section: Resultsmentioning

confidence: 99%

“…Earlier evidence indicated that the small particles can reach bronchioles and penetrate up to the primary, secondary terminal bronchi, and alveoli in the lung which may trigger mucous secretions in airways, reduce air flow and then cause wheezing (54,55). Although previous studies reported significant effects of PM 10 on respiratory diseases in children (27,52,56), the effects on wheeze-associated disorders was not clear. We found significant associations in some sensitivity analyses but those results were based on removing a large study or including lower quality score studies into meta-analysis so we concluded that further studies were needed to clarify this association.…”

Section: Discussionmentioning

confidence: 99%

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Impact of ambient air pollution and wheeze-associated disorders in children in Southeast Asia: a systematic review and meta-analysis

Luong

Sly

Thai

et al. 2019

Reviews on Environmental Health

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Abstract Several systematic reviews have been conducted so far to examine the effect of air pollution on respiratory diseases, but there has not been a corresponding meta-analysis to estimate the effect sizes for wheeze-associated diseases/disorders, which is one of the leading causes of emergency department visits and hospitalizations for children worldwide. The aim of this review is to systematically evaluate the relationship between air pollution and risk of wheeze-associated disorders in children in Southeast Asia. We searched the relevant computerized databases (PubMed, EMBASE, Web of Science, Scopus and Cochrane library) for indexed publications up to July 2018. Finally, eight studies were qualified for performing a random-effect meta-analysis to compute the pooled effect sizes. The results show that each increase of 10 μg/m3 in concentrations of PM2.5, PM1 was associated with 1–2% increase in risk of wheeze-associated disorders. Positive associations were found for PM10, SO2, NO2, NOx but no association was found for CO and O3. We confirmed the strong effect of fine particulate matters on respiratory health and recommend an updated meta-analysis should be done when more studies are available.

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Section: Discussionsupporting

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Impact of ambient air pollution and wheeze-associated disorders in children in Southeast Asia: a systematic review and meta-analysis

Luong

Sly

Thai

et al. 2019

Reviews on Environmental Health

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Exposure to Air Pollution and Emergency Department Visits During the First Year of Life Among Preterm and Full-term Infants

et al. 2023

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ImportancePrevious studies have focused on exposure to fine particulate matter 2.5 μm or less in diameter (PM2.5) and on birth outcome risks; however, few studies have evaluated the health consequences of PM2.5 exposure on infants during their first year of life and whether prematurity could exacerbate such risks.ObjectiveTo assess the association of PM2.5 exposure with emergency department (ED) visits during the first year of life and determine whether preterm birth status modifies the association.Design, Setting, and ParticipantsThis individual-level cohort study used data from the Study of Outcomes in Mothers and Infants cohort, which includes all live-born, singleton deliveries in California. Data from infants’ health records through their first birthday were included. Participants included 2 175 180 infants born between 2014 and 2018, and complete data were included for an analytic sample of 1 983 700 (91.2%). Analysis was conducted from October 2021 to September 2022.ExposuresWeekly PM2.5 exposure at the residential ZIP code at birth was estimated from an ensemble model combining multiple machine learning algorithms and several potentially associated variables.Main Outcomes and MeasuresMain outcomes included the first all-cause ED visit and the first infection- and respiratory-related visits separately. Hypotheses were generated after data collection and prior to analysis. Pooled logistic regression models with a discrete time approach assessed PM2.5 exposure and time to ED visits during each week of the first year of life and across the entire year. Preterm birth status, sex, and payment type for delivery were assessed as effect modifiers.ResultsOf the 1 983 700 infants, 979 038 (49.4%) were female, 966 349 (48.7%) were Hispanic, and 142 081 (7.2%) were preterm. Across the first year of life, the odds of an ED visit for any cause were greater among both preterm (AOR, 1.056; 95% CI, 1.048-1.064) and full-term (AOR, 1.051; 95% CI, 1.049-1.053) infants for each 5-μg/m3 increase in exposure to PM2.5. Elevated odds were also observed for infection-related ED visit (preterm: AOR, 1.035; 95% CI, 1.001-1.069; full-term: AOR, 1.053; 95% CI, 1.044-1.062) and first respiratory-related ED visit (preterm: AOR, 1.080; 95% CI, 1.067-1.093; full-term: AOR,1.065; 95% CI, 1.061-1.069). For both preterm and full-term infants, ages 18 to 23 weeks were associated with the greatest odds of all-cause ED visits (AORs ranged from 1.034; 95% CI, 0.976-1.094 to 1.077; 95% CI, 1.022-1.135).Conclusions and RelevanceIncreasing PM2.5 exposure was associated with an increased ED visit risk for both preterm and full-term infants during the first year of life, which may have implications for interventions aimed at minimizing air pollution.

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Concentrations of nitrogen compounds are related to severe rhinovirus infection in infants. A time‐series analysis from the reference area of a pediatric university hospital in Barcelona

Armero

Penela‐Sánchez

Belmonte

et al. 2022

Pediatric Pulmonology

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Background There is scarce information focused on the effect of weather conditions and air pollution on specific acute viral respiratory infections, such as rhinovirus (RV), with a wide clinical spectrum of severity. Objective The aim of this study was to analyze the association between episodes of severe respiratory tract infection by RV and air pollutant concentrations (NOx and SO2) in the reference area of a pediatric university hospital. Methods An analysis of temporal series of daily values of NOx and SO2, weather variables, circulating pollen and mold spores, and daily number of admissions in the pediatric intensive care unit (PICU) with severe respiratory RV infection (RVi) in children between 6 months and 18 years was performed. Lagged variables for 0–5 days were considered. The study spanned from 2010 to 2018. Patients with comorbidities were excluded. Results One hundred and fifty patients were admitted to the PICU. Median age was 19 months old (interquartile range [IQR]: 11–47). No relationship between RV‐PICU admissions and temperature, relative humidity, cumulative rainfall, or wind speed was found. Several logistic regression models with one pollutant and two pollutants were constructed but the best model was that which included average daily NOx concentrations. Average daily NOx concentrations were related with the presence of PICU admissions 3 days later (odds ratio per IQR‐unit increase: 1.64, 95% confidence interval: 1.20–2.25)). Conclusions This study has shown a positive correlation between NOx concentrations at Lag 3 and children's PICU admissions with severe RV respiratory infection. Air pollutant data should be taken into consideration when we try to understand the severity of RVis.

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Acute effects of ambient air pollution on lower respiratory infections in Hanoi children: An eight-year time series study

Abstract: Strong associations between hospital admissions for lower respiratory infections and daily levels of air pollution confirm the need to adopt sustainable clean air policies in Vietnam to protect children's health.

Cited by 166 publications

References 32 publications

Impact of ambient air pollution and wheeze-associated disorders in children in Southeast Asia: a systematic review and meta-analysis

Impact of ambient air pollution and wheeze-associated disorders in children in Southeast Asia: a systematic review and meta-analysis

Exposure to Air Pollution and Emergency Department Visits During the First Year of Life Among Preterm and Full-term Infants

Concentrations of nitrogen compounds are related to severe rhinovirus infection in infants. A time‐series analysis from the reference area of a pediatric university hospital in Barcelona

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