Acute effects of alcohol on resting-state functional connectivity in healthy young men

Han, Jiaxu; Keedy, Sarah K.; Murray, Conor H.; Foxley, Sean; Wit, Harriet de

doi:10.1016/j.addbeh.2020.106786

Cited by 17 publications

(8 citation statements)

References 59 publications

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“…For example, studies reported that substances administration significantly increased FC between reward-related regions and the sensory cortex including LOC and STG respectively. 36,37 In addition, drug cues compared with neutral cues evoked higher activity of the right LOC in the MUDs and the activity was also higher in the MUDs than in the HCs. 32 A structural MRI study also reported altered structural features of the right LOC in the MUDs.…”

Section: Discussionmentioning

confidence: 89%

Mapping structural covariance networks of emotional withdrawal symptoms in males with methamphetamine use disorder during abstinence

Mo,

Jiang,

Sun

et al. 2024

Addiction Biology

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Individuals with methamphetamine use disorder (MUD) often experience anxiety and depressive symptoms during abstinence, which can worsen the likelihood of relapse. Thus, it is essential to understand the neuro‐mechanism behind methamphetamine use and its associated emotional withdrawal symptoms in order to develop effective clinical strategies. This study aimed to evaluate associations between emotional withdrawal symptoms and structural covariance networks (SCNs) based on cortical thickness (CTh) across the brain. The CTh measures were obtained from Tl‐weighted MRI data from a sample of 48 males with MUD during abstinence and 48 male healthy controls. The severity of anxiety and depressive symptoms was assessed by the Hamilton Anxiety Scale (HAMA) and depression (HAMD) scales. Two important nodes belonging to the brain reward system, the right rostral anterior cingulate cortex (rACC) and medial prefrontal cortex (medPFC), were selected as seeds to conduct SCNs and modulation analysis by emotional symptoms. MUDs showed higher structural covariance between the right rACC and regions in the dorsal attention, right frontoparietal, auditory, visual and limbic networks. They also displayed higher structural covariance between the right medPFC and regions in the limbic network. Moreover, the modulation analysis showed that higher scores on HAMA were associated with increased covariance between the right rACC and the left parahippocampal and isthmus cingulate cortex in the default mode network. These outcomes shed light on the complex neurobiological mechanisms underlying methamphetamine use and its associated emotional withdrawal symptoms and may provide new insights into the development of effective treatments for MUD.

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Section: Discussionmentioning

confidence: 89%

Mapping structural covariance networks of emotional withdrawal symptoms in males with methamphetamine use disorder during abstinence

Mo,

Jiang,

Sun

et al. 2024

Addiction Biology

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“…between these areas at rest following acute alcohol administration (Boissoneault et al, 2020; but see Han et al, 2021) and in abstinent heavy drinkers during a monetary reward task (Forbes et al, 2014).…”

Section: Discussion Overviewmentioning

confidence: 99%

“…In healthy adults, a pain modulation training protocol that reduced experimental pain sensitivity also reduced resting connectivity between these structures (Sevel et al, 2020). At the same time, alterations in connectivity have been detected between these areas at rest following acute alcohol administration (Boissoneault et al, 2020; but see Han et al, 2021) and in abstinent heavy drinkers during a monetary reward task (Forbes et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Analgesic effects of alcohol in adults with chronic jaw pain

Vitus

Williams

Rizk

et al. 2022

Alcoholism Clin & Exp Res

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Background Although recent literature provides promising support for the analgesic properties of alcohol, potential differences in alcohol analgesia as a function of chronic pain status are not well understood. Thus, this study examined chronic pain status as a potential moderator of alcohol analgesia and distinguished between multiple aspects of pain experience and sensitivity: pain threshold, pain intensity, pain unpleasantness, and perceived relief. Methods Social drinkers with (N = 19) and without (N = 29) chronic jaw pain completed two testing sessions in a counterbalanced order: alcohol (target BrAC = 0.08 g/dl) and placebo. In each, pressure algometry was performed at the insertion of the masseter. Alcohol analgesia was assessed by examining the main and interactive effects of beverage condition, pressure level (4, 5, or 6 pound‐feet [lbf]), and chronic jaw pain status (chronic pain vs. pain‐free control) on quantitative sensory testing measures and pain relief ratings following noxious stimuli. Results Analyses indicated significant increases in pain threshold and pain relief and reductions in pain unpleasantness and pain intensity, under the alcohol condition. Chronic pain participants demonstrated lower pain thresholds and greater pain intensity and pain unpleasantness ratings than controls. There were no interactive effects of alcohol and pain conditions on any pain measure. Conclusions Findings provide experimental evidence of alcohol's analgesic and pain‐relieving effects and suggest that these effects do not significantly differ by chronic pain status. Individuals, who self‐medicate pain via alcohol consumption, irrespective of pain status, may be at increased risk to engage in hazardous drinking patterns and thus experience adverse alcohol‐related consequences.

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“…Many efforts have been devoted to the exploration of functional connectivity, and significantly altered functional connectivity patterns in patients with AUD were found by many researchers. For example, Han et al have reported in a resting-state fMRI study that alcohol addicts showed a wide range of abnormal functional connections including the frontal lobe, anterior cingulate gyrus, bilateral insula, thalamus, precuneus, left caudate nucleus, and some temporal and occipital lobes (Han et al, 2021 ). Compared with the healthy control (HC), the AUD group decreased in the right anterior cuneiform lobe and left cerebellar peduncle II area, but increased in the left posterior cingulate gyrus, right middle temporal gyrus, right superior temporal gyrus, and right anterior cuneiform lobe area, indicating an abnormal default mode network function (DMN) (Khan et al, 2021a ), where was later found to have increased functional connectivity in patients with AUD (Yang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The altered functional connectivity density related to cognitive impairment in alcoholics

Duan

Jing

et al. 2022

Front. Psychol.

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Alcohol use disorder (AUD) is one of the most common substance use disorders contributing to both behavioral and cognitive impairments in patients with AUD. Recent neuroimaging studies point out that AUD is a typical disorder featured by altered functional connectivity. However, the details about how voxel-wise functional coordination remain unknown. Here, we adopted a newly proposed method named functional connectivity density (FCD) to depict altered voxel-wise functional coordination in AUD. The novel functional imaging technique, FCD, provides a comprehensive analytical method for brain's “scale-free” networks. We applied resting-state functional MRI (rs-fMRI) toward subjects to obtain their FCD, including global FCD (gFCD), local FCD (lFCD), and long-range FCD (lrFCD). Sixty-one patients with AUD and 29 healthy controls (HC) were recruited, and patients with AUD were further divided into alcohol-related cognitive impairment group (ARCI, n = 11) and non-cognitive impairment group (AUD-NCI, n = 50). All subjects were asked to stay stationary during the scan in order to calculate the resting-state gFCD, lFCD, and lrFCD values, and further investigate the abnormal connectivity alterations among AUD-NCI, ARCI, and HC. Compared to HC, both AUD groups exhibited significantly altered gFCD in the left inferior occipital lobe, left calcarine, altered lFCD in right lingual, and altered lrFCD in ventromedial frontal gyrus (VMPFC). It is notable that gFCD of the ARCI group was found to be significantly deviated from AUD-NCI and HC in left medial frontal gyrus, which changes probably contributed by the impairment in cognition. In addition, no significant differences in gFCD were found between ARCI and HC in left parahippocampal, while ARCI and HC were profoundly deviated from AUD-NCI, possibly reflecting a compensation of cognition impairment. Further analysis showed that within patients with AUD, gFCD values in left medial frontal gyrus are negatively correlated with MMSE scores, while lFCD values in left inferior occipital lobe are positively related to ADS scores. In conclusion, patients with AUD exhibited significantly altered functional connectivity patterns mainly in several left hemisphere brain regions, while patients with AUD with or without cognitive impairment also demonstrated intergroup FCD differences which correlated with symptom severity, and patients with AUD cognitive impairment would suffer less severe alcohol dependence. This difference in symptom severity probably served as a compensation for cognitive impairment, suggesting a difference in pathological pathways. These findings assisted future AUD studies by providing insight into possible pathological mechanisms.

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Acute effects of alcohol on resting-state functional connectivity in healthy young men

Cited by 17 publications

References 59 publications

Mapping structural covariance networks of emotional withdrawal symptoms in males with methamphetamine use disorder during abstinence

Mapping structural covariance networks of emotional withdrawal symptoms in males with methamphetamine use disorder during abstinence

Analgesic effects of alcohol in adults with chronic jaw pain

The altered functional connectivity density related to cognitive impairment in alcoholics

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