Acute Effects of a Fungal Volatile Compound

Wålinder, Robert; Ernstgård, Lena; Johanson, Gunnar; Norbäck, Dan; Venge, Per; Wieslander, Gunilla

doi:10.1289/ehp.8193

Cited by 61 publications

(45 citation statements)

References 21 publications

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“…These results are supported by two experimental studies on humans that found significant objective and subjective signs of mild mucosal irritation in the eyes and airways during exposure to 3-methylfruran or 1-octen-3-ol over a period of 2 h in a closed chamber (Wålinder et al, 2005;Wålinder et al, 2008). Korpi et al (1999) found that 1-octen-3-ol is more potent than other compounds and that its effect is stronger when combined with other compounds.…”

Section: Microbial Volatile Organic Compounds (Mvocs) Include a Rangementioning

confidence: 67%

“…According to a more recent review of the literature, the most obvious adverse health effects of MVOC exposure are eye and upper-airway irritation (Korpi et al, 2009). The exposure levels found in the chamber studies mentioned above were 1 mg/m 3 for 3-methylfuran and 10 mg/m 3 for 1-octen-3-ol (Wålinder et al, 2005;. The recommended maximum level of 1-octen-3-ol for indoor air, based on data from animal studies, is estimated to be 100 µg/m 3 (Korpi et al, 1999).…”

Section: Microbial Volatile Organic Compounds (Mvocs) Include a Rangementioning

confidence: 99%

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The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes

Araki

Kanazawa

Kawai

et al. 2012

Science of The Total Environment

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Microbial volatile organic compounds (MVOCs) are a type of VOCs produced by microorganisms. Exposure to 1-octen-3-ol, one of the known MVOCs, has been reported to reduce nasal patency and increase nasal lavage myeloperoxidase, eosinophil cationic proteins, and lysozymes in both experimental and field studies. We reported in a previous paper that 1-octen-3-ol exposure at home is associated with mucosal symptoms. In this study, our aim was to investigate the relationship between asthma and allergies and MVOC exposure in single-family homes. The subjects were 624 inhabitants of 182 detached houses in six regions of Japan. Air samples were collected using diffusive samplers, and the concentrations of eight selected MVOCs were analyzed using gas chromatography/mass spectrometry in selected-ion-monitoring mode. Each inhabitant of each of the dwellings was given a self-administered questionnaire. Among the 609 subjects who answered all of the questions about allergies, history of the medical treatment for asthma, atopic dermatitis, allergic rhinitis, and allergic conjunctivitis within the past two years was 4.8%, 9.9%, 18.2%, and 7.1 %, respectively. A significant association between 1-octen-3-ol (per log 10 unit) and allergic rhinitis odds ratio (OR): 4.10, 95% confidence interval (CI): 1.71 to 9.80 and conjunctivitis (OR: 3.54, CI: 1.17 to 10.7) was found after adjusting for age, sex, environmental-tobacco-smoke exposure, wall-to-wall carpeting in the home, signs of dampness, history of treatment for hay fever, and other potentially relevant environmental factors. No relationships were found between any MVOCs and asthma or atopic dermatitis after the adjustment. The levels of MVOCs and airborne fungi were only weakly correlated. These results are consistent with previous studies that have associated higher levels of 1-octen-3-ol exposure with increased irritation of nasal 4 and ocular mucosae. Although the indoor-air concentrations of 1-octen-3-ol found in this study were relatively low, we conclude that exposure to MVOC may be related to rhinitis and conjunctivitis.

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Section: Microbial Volatile Organic Compounds (Mvocs) Include a Rangementioning

confidence: 67%

Section: Microbial Volatile Organic Compounds (Mvocs) Include a Rangementioning

confidence: 99%

The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes

Araki

Kanazawa

Kawai

et al. 2012

Science of The Total Environment

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“…However, concentrations measured in experimental human studies are 1 and 10 mg/m 3 for 1-octen-3-ol and 3-methylfran, respectively, (Wålinder et al, 2005;Wålinder et al, 2008), while in animal studies they range from 58 to more than 10,000 mg/m 3 for 1-octen-3-ol, 3-octanol and 3-octanone (Korpi et al, 1999). These are higher than levels measured indoors.…”

Section: Introductionmentioning

confidence: 76%

“…One such example, 3-methylfuran, was reported to cause acute effects in mucous membranes in a human experimental study (Wålinder et al, 2005). Another such example, 2-ethylhexanol, is used as a solvent but is also derived from microorganisms (Nalli et al, 2006) and shares some chemosensory features with other long chain alcohols, such as 1-octanol.…”

Section: Discussionmentioning

confidence: 99%

“…3-Methylfuran and 1-octen-3-ol are commonly produced by mold (Borjesson et al, 1992;Borjesson et al, 1993;Korpi et al, 1997;Matysik et al, 2008). In human chamber studies, these compounds caused acute effects, such as objective and/or subjective signs of mild mucosal irritation of the eyes and airways due to exposure (Wålinder et al, 2005;Walinder et al, 2008). According to one animal study, 1-octen-3-ol caused a 50% decrease in respiratory rate for mice, and at the same time, a mixture of several chemicals may have some synergistic effects.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

Araki

Kawai

Eitaki

et al. 2010

Science of The Total Environment

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Abstract:Micro-organisms are known to produce a range of volatile organic compounds, so-called microbial VOC (MVOC). Chamber studies where humans were exposed to MVOC addressed the acute effects of objective and/or subjective signs of mucosal irritation. However, the effect of MVOC on inhabitants due to household exposure is still unclear. The purpose of this epidemiological study was to measure indoor MVOC levels in single family homes and to evaluate the relationship between exposure to them and sick building syndrome (SBS). All inhabitants of the dwellings were given a self-administered questionnaire with standardized questions to assess their symptoms.Air samples were collected and the concentrations of eight selected compounds in indoor air were analyzed by gas chromatography/mass spectrometry -selective ion monitoring mode (GC/MS-SIM). The most frequently detected MVOC was 1-pentanol at a detection rate of 78.6% and geometric mean of 0.60 μg/m 3 . Among 620 participants, 120 (19.4%) reported one or more mucous symptoms; irritation of the eyes, nose, airway, or coughing every week (weekly symptoms), and 30 (4.8%) reported that the symptoms were home-related (home-related symptoms). Weekly symptoms were not associated with any of MVOC, whereas significant associations between home-related mucous symptoms and 1-octen-3-ol (per log 10 -unit: odds ratio (OR) 5.6, 95% confidence interval (CI): 2.1 to 14.8) and 2-pentanol (per log 10 -unit: OR 2.3, 95%CI: 1.0 to 4.9) were obtained after adjustment for gender, age, and smoking.Associations between home-related symptoms and 1-octen-3-ol remained after mutual adjustment. However, concentrations of the selected compounds in indoors were lower than the estimated safety level in animal studies. Thus, the statistically significant association between 1-octen-3-ol may be due to a direct effect of the compounds or the associations may be being associated with other offending compounds. Additional studies are needed to evaluate these possibilities.

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How Healthy Is Healthy? Comparison Between Self-Reported Symptoms and Clinical Outcomes in Connection with the Enrollment of Volunteers for Human Exposure Studies on Sensory Irritation Effects

Rosenkranz

Bünger

Hoffmeyer

et al. 2020

Advances in Experimental Medicine and Biology

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Acute Effects of a Fungal Volatile Compound

Cited by 61 publications

References 21 publications

The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes

The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes

Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

How Healthy Is Healthy? Comparison Between Self-Reported Symptoms and Clinical Outcomes in Connection with the Enrollment of Volunteers for Human Exposure Studies on Sensory Irritation Effects

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