Acute effects of 1-octen-3-ol, a microbial volatile organic compound (MVOC)—An experimental study

Wålinder, Robert; Ernstgård, Lena; Norbäck, Dan; Wieslander, Gunilla; Johanson, Gunnar

doi:10.1016/j.toxlet.2008.07.013

Cited by 50 publications

(48 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, concentrations measured in experimental human studies are 1 and 10 mg/m 3 for 1-octen-3-ol and 3-methylfran, respectively, (Wålinder et al, 2005;Wålinder et al, 2008), while in animal studies they range from 58 to more than 10,000 mg/m 3 for 1-octen-3-ol, 3-octanol and 3-octanone (Korpi et al, 1999). These are higher than levels measured indoors.…”

Section: Introductionmentioning

confidence: 76%

Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

Araki

Kawai

Eitaki

et al. 2010

Science of The Total Environment

View full text Add to dashboard Cite

Abstract:Micro-organisms are known to produce a range of volatile organic compounds, so-called microbial VOC (MVOC). Chamber studies where humans were exposed to MVOC addressed the acute effects of objective and/or subjective signs of mucosal irritation. However, the effect of MVOC on inhabitants due to household exposure is still unclear. The purpose of this epidemiological study was to measure indoor MVOC levels in single family homes and to evaluate the relationship between exposure to them and sick building syndrome (SBS). All inhabitants of the dwellings were given a self-administered questionnaire with standardized questions to assess their symptoms.Air samples were collected and the concentrations of eight selected compounds in indoor air were analyzed by gas chromatography/mass spectrometry -selective ion monitoring mode (GC/MS-SIM). The most frequently detected MVOC was 1-pentanol at a detection rate of 78.6% and geometric mean of 0.60 μg/m 3 . Among 620 participants, 120 (19.4%) reported one or more mucous symptoms; irritation of the eyes, nose, airway, or coughing every week (weekly symptoms), and 30 (4.8%) reported that the symptoms were home-related (home-related symptoms). Weekly symptoms were not associated with any of MVOC, whereas significant associations between home-related mucous symptoms and 1-octen-3-ol (per log 10 -unit: odds ratio (OR) 5.6, 95% confidence interval (CI): 2.1 to 14.8) and 2-pentanol (per log 10 -unit: OR 2.3, 95%CI: 1.0 to 4.9) were obtained after adjustment for gender, age, and smoking.Associations between home-related symptoms and 1-octen-3-ol remained after mutual adjustment. However, concentrations of the selected compounds in indoors were lower than the estimated safety level in animal studies. Thus, the statistically significant association between 1-octen-3-ol may be due to a direct effect of the compounds or the associations may be being associated with other offending compounds. Additional studies are needed to evaluate these possibilities.

show abstract

Section: Introductionmentioning

confidence: 76%

Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

Araki

Kawai

Eitaki

et al. 2010

Science of The Total Environment

View full text Add to dashboard Cite

show abstract

“…More recently, we showed that 100 ppm of volatilized 1-octen-3-ol was 80 times more toxic than toluene in human embryonic stem cells (34). Human volunteers exposed to 1.9 ppm of 1-octen-3-ol for 2 h experienced irritative symptoms, along with increases in inflammatory markers, eosinophil cationic protein, myeloperoxidase, lysozyme, and albumin in the nasal secretions (35). In this report, survival duration was truncated in Drosophila exposed to 1-octen-3-ol vapor at lower concentrations (0.5 ppm).…”

Section: Discussionmentioning

confidence: 98%

Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration

Inamdar

Hossain

Bernstein

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Parkinson disease (PD) is the most common movement disorder and, although the exact causes are unknown, recent epidemiological and experimental studies indicate that several environmental agents may be significant risk factors. To date, these suspected environmental risk factors have been man-made chemicals. In this report, we demonstrate via genetic, biochemical, and immunological studies that the common volatile fungal semiochemical 1-octen-3-ol reduces dopamine levels and causes dopamine neuron degeneration in Drosophila melanogaster. Overexpression of the vesicular monoamine transporter (VMAT) rescued the dopamine toxicity and neurodegeneration, whereas mutations decreasing VMAT and tyrosine hydroxylase exacerbated toxicity. Furthermore, 1-octen-3-ol also inhibited uptake of dopamine in human cell lines expressing the human plasma membrane dopamine transporter (DAT) and human VMAT ortholog, VMAT2. These data demonstrate that 1-octen-3-ol exerts toxicity via disruption of dopamine homeostasis and may represent a naturally occurring environmental agent involved in parkinsonism.building-related illness | mold | mushroom alcohol

show abstract

“…Three categories of MVOC were analysed, 3-methylfuran, 1-ocgten-3-ol, and TMVOC. Two of the MVOC were analysed separately because they have been demonstrated to have eVects on biomarkers in two experimental exposure chamber studies (Wålinder et al 2005, (3-metylfuran); Wålinder et al 2008 (1-octen-3-ol)). Tear Wlm break-up time was signiWcantly reduced at higher levels of 2-phenoxy ethanol only.…”

Section: Associations Between Measured Exposure and Biomarkersmentioning

confidence: 99%

“…An association between MVOC concentrations in schools, including 1-octen-3ol (range <1-210 ng/m 3 ), and asthmatic symptoms have been reported (Kim et al 2007). One exposure chamber study using 2-h exposure to considerably higher levels of 1-octen-3-ol (10 mg/m 3 ) demonstrated an increase in NAL-MPO, NAL-ECP, and NAL-lysozyme after the exposure (Wålinder et al 2008). A recent review on 15 common MVOC concluded that there is evidence of an eVect on ocular and nasal mucosa, but the toxicological database is poor even for these compounds (Korpi et al 2009).…”

Section: Biomarkermentioning

confidence: 99%

Ocular symptoms, tear film stability, nasal patency, and biomarkers in nasal lavage in indoor painters in relation to emissions from water-based paint

Wieslander

Norbäck

2010

Int Arch Occup Environ Health

Self Cite

View full text Add to dashboard Cite

show abstract

Acute effects of 1-octen-3-ol, a microbial volatile organic compound (MVOC)—An experimental study

Cited by 50 publications

References 30 publications

Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration

Ocular symptoms, tear film stability, nasal patency, and biomarkers in nasal lavage in indoor painters in relation to emissions from water-based paint

Contact Info

Product

Resources

About