Acute effect of twice-daily 15 mA transcranial alternating current stimulation on treatment-resistant depression: a case series study

Zhao, Wenfeng; Wang, Huang; Leng, Haixia; Xue, Qing; Peng, Mao; Jin, Xiukun; Tan, Liucen; Pan, Na; Wang, Xuedi; Wang, Jie; Gao, Keming; Zhang, Xiangyang; Wang, Hongxing

doi:10.1136/gpsych-2023-101278

Cited by 2 publications

(1 citation statement)

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“…2 Furthermore, the efficiency of the tACS with a sizeable current intensity, such as 15 mA, is still unknown for the clinical treatment of patients with depression and insomnia. [5][6][7] For human studies, different studies have applied different current intensities to treat insomnia, chronic painful conditions, anxiety and depression. 5 6 8-10 Our recent studies have demonstrated that tACS with a current of 15 mA and a frequency of 77.5 Hz delivered via a configuration of the forehead and both mastoids was a safe and effective intervention for chronic insomnia and depression over 8 weeks.…”

Section: General Psychiatrymentioning

confidence: 99%

Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder

Wang,

Zhao,

Wang

et al. 2024

Gen Psych

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BackgroundAlthough 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown.AimsTo investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA, delivered via the forehead and the mastoid electrodes in the human brain.MethodsActual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve, first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS software.ResultsThe electric field distributions of the sagittal, coronal and axial planes showed that the bilateral frontal lobes, bilateral temporal lobes, hippocampus, cingulate, hypothalamus, thalamus, amygdala, cerebellum and brainstem were visibly stimulated by the 15 mA tACS procedure.ConclusionsBrain-wide activation, including the cortex, subcortical structures, cerebellum and brainstem, is involved in the 15 mA tACS intervention for first-episode major depressive disorder. Our results indicate that the simultaneous involvement of multiple brain regions is a possible mechanism for its effectiveness in reducing depressive symptoms.

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Section: General Psychiatrymentioning

confidence: 99%

Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder

Wang,

Zhao,

Wang

et al. 2024

Gen Psych

Self Cite

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Altered Neuronal Activity Patterns of the Prefrontal Cortex in Alzheimer’s Disease After Transcranial Alternating Current Stimulation: A Resting-State fMRI Study

Wang,

Yan,

Shan

et al. 2024

JAD

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Background: Transcranial alternating current stimulation (tACS) could improve cognition in patients with Alzheimer’s disease (AD). However, the effects of tACS on brain activity remain unclear. Objective: The purpose is to investigate the change in regional neuronal activity after tACS in AD patients employing resting-state functional magnetic resonance imaging (rs-fMRI). Methods: A total of 46 patients with mild AD were enrolled. Each patient received 30 one-hour sessions of real or sham tACS for three weeks (clinical trial: NCT03920826). The fractional amplitude of low-frequency fluctuations (fALFF) and the regional homogeneity (ReHo) measured by rs-fMRI were calculated to evaluate the regional brain activity. Results: Compared to baseline, AD patients in the real group exhibited increased fALFF in the left middle frontal gyrus-orbital part and right inferior frontal gyrus-orbital part, as well as increased ReHo in the left precentral gyrus and right middle frontal gyrus at the end of intervention. At the 3-month follow-up, fALFF increased in the left superior parietal lobule and right inferior temporal gyrus, as well as ReHo, in the left middle frontal gyrus and right superior medial frontal gyrus. A higher fALFF in the right lingual gyrus and ReHo in the right parahippocampal gyrus were observed in the response group than in the nonresponse group. Conclusions: The findings demonstrated the beneficial effects of tACS on the neuronal activity of the prefrontal cortex and even more extensive regions and provided a neuroimaging biomarker of treatment response in AD patients.

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Acute effect of twice-daily 15 mA transcranial alternating current stimulation on treatment-resistant depression: a case series study

Abstract: ⇒ More exploration of twice-daily 15 mA tACS for TRD in large clinical studies could strengthen our preliminary results indicating that it is a promising alternative intervention with practical treatment implications for TRD.

Cited by 2 publications

References 15 publications

Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder

Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder

Altered Neuronal Activity Patterns of the Prefrontal Cortex in Alzheimer’s Disease After Transcranial Alternating Current Stimulation: A Resting-State fMRI Study

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