Acute effect of oat β-glucan on the bioavailability of orange juice flavanones

Pereira‐Caro, Gema; Almutairi, Tahani Mazyad; Crozier, Alan; Ordóñez-Díaz, José Luis; Moreno‐Rojas, José Manuel; Ortiz-Somovilla, Víctor; Santander, Beatriz Gabriela Morillo; Lazarova, Svilena; Malkova, Dalia; García, Ada L.

doi:10.1080/09637486.2021.2015572

Cited by 2 publications

(1 citation statement)

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“…In general, dietary fiber may affect the bioavailability of (poly)phenols by modifying the gut microbial composition and activity (Lu et al., 2017; Matsukawa et al., 2009; Nishijima et al., 2015). Co‐ingestion of orange juice with 6 g of oat β‐glucan significantly reduced (3.1‐fold) the amount of flavanone metabolites recovered in urine, most likely by increasing the viscosity of the chyme and hindering absorption in the gut (Pereira‐Caro et al., 2022). On the contrary, few studies have reported that fiber enhanced quercetin bioavailability, as assessed by quercetin metabolites in plasma and urine (Matsukawa et al., 2009; Nishijima et al., 2015).…”

Section: Factors Affecting Citrus (Poly)phenol Bioavailabilitymentioning

confidence: 99%

Review of factors affecting citrus polyphenol bioavailability and their importance in designing in vitro, animal, and intervention studies

Visvanathan

Williamson

2022

Comp Rev Food Sci Food Safe

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Evidence from in vitro, animal, and human studies links citrus fruit consumption with several health-promoting effects. However, many in vitro studies disregard bioavailability data, a key factor determining responses in humans. Citrus (poly)phenol metabolism and bioavailability follow specific pathways that vary widely among individuals and are affected by several intrinsic (age, sex, gut microbiota, metabolic state, genetic polymorphisms) and extrinsic (food matrix, co-consumed food, (poly)phenol solubility, dose, food processing, lifestyle) factors. The gut microbiota is crucial to both absorption of citrus (poly)phenols and the production of catabolites, and absorption of both takes place mostly in the colon. Citrus (poly)phenol absorption can reach up to 100% in some individuals when the sum of the gut microbiota products are taken into account. This review emphasizes the importance of understanding citrus (poly)phenol absorption, metabolism, and bioavailability using evidence primarily derived from human studies in designing in vitro, animal, and further human clinical studies.

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