Acute effect of nitroglycerin on cyclosporine-induced hypertension after cardiac transplantation

Sudano, Isabella; Farshad, Mazda; Flammer, Andreas J.; Spieker, LE; Périat, Daniel; Enseleit, Frank

doi:10.4414/smw.2010.12966

Cited by 2 publications

(1 citation statement)

References 51 publications

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“…Nitric oxide supplementation with intravenous supply of nitroglycerin after cardiac transplantation has a more pronounced and longer-lasting hypotensive response in patients receiving CsA than in those with essential HT. 51 Unfortunately, the use of isosorbide mononitrate for 7 weeks causes an adverse procoagulant effect and intensifies vasoconstriction by upsetting the balance of thromboxane and prostacyclin concentrations. 52 Calcium channel blockers have proven to be effective vasodilators.…”

Section: Ht After Organ Transplantationmentioning

confidence: 99%

Treatment of Hypertension Because of Immunosuppressive Therapy After Solid Organ Transplantation—Pharmacological Approach

Gilewski

Banach

Rogowicz

et al. 2021

Journal of Cardiovascular Pharmacology

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:Solid organs transplantation procedures have been performed for more than half a century. Growing knowledge of immune response and development of new immunosuppressive regimens guarantee more and more successful outcomes. However, many of the applied drugs lead to cardiovascular complications, the most frequent of which is hypertension. This article describes epidemiology, pathogenetic mechanisms, and treatment of hypertension induced by immunosuppressive medication. The main impact is focused on drugs belonging to the following groups: calcineurin inhibitors, the inhibitors of the mammalian target of rapamycin, and glucocorticosteroids. We analyze the mechanism of action of the main hypertensive drugs and their influence on the reversing hypertonic action of the immunosuppressive agents. In the absence of current guidelines addressing this problem, this article is an attempt to fill the gap, helping clinicians to choose proper medication.

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Section: Ht After Organ Transplantationmentioning

confidence: 99%

Treatment of Hypertension Because of Immunosuppressive Therapy After Solid Organ Transplantation—Pharmacological Approach

Gilewski

Banach

Rogowicz

et al. 2021

Journal of Cardiovascular Pharmacology

View full text Add to dashboard Cite

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Cyclosporine Toxicity and Toxicokinetics Profiles in Renal Transplant Recipients

Ragab¹,

Al-Mazroua²,

Al-Dakrory³

2013

J Clin Toxicol

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Background: Cyclosporine is the backbone of immunosuppression in kidney transplantation. However, it leads to multiple toxic effects, most of which are dose-dependent. In this respect, the quality of renal functions is undoubtedly linked to cyclosporine drug levels. Objective: To evaluate the association among cyclosporine trough-peak levels, dosage and its toxic effects. Methods and materials: In 102 kidney transplant recipients, serum cyclosporine trough-peak levels, serum creatinine, blood urea, blood urea and nitrogen, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase were measured periodically from the beginning of May, 2011 until the end of July, 2012. The relationships among previous laboratory parameters were detected in relation to the prevalence of toxic cyclosporine effects. Results: Consequently, the patients are with renal transplantations; concentrations of cyclosporine trough that can get lowered safely towards the range of 150-200 ng/ml, added by minimal toxic cyclosporine effects without increased risk for graft rejection. Conclusion: The findings of this study showed the detrimental toxic effects of high cyclosporine concentrations and the efficiency of low cyclosporine trough/peak levels in maintaining of an efficient immunosuppressive effect plus a minimal toxic cyclosporine effects and positive therapeutic outcomes in the renal transplant patients.

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Acute effect of nitroglycerin on cyclosporine-induced hypertension after cardiac transplantation

Cited by 2 publications

References 51 publications

Treatment of Hypertension Because of Immunosuppressive Therapy After Solid Organ Transplantation—Pharmacological Approach

Treatment of Hypertension Because of Immunosuppressive Therapy After Solid Organ Transplantation—Pharmacological Approach

Cyclosporine Toxicity and Toxicokinetics Profiles in Renal Transplant Recipients

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