Acute effect of intranasal estrogen on cerebral and cerebellar perfusion in postmenopausal women

Kaya, Eser; Şahin, Figen Kır; Köken, Gülengül; Köse, Mesut; Cevrioğlu, Arif Serhan

doi:10.1016/j.maturitas.2007.10.004

Cited by 17 publications

(18 citation statements)

References 48 publications

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“…Further, this cerebellar blood flow increase correlates with an increase in serum levels of estradiol [143]. Intranasal administration of estrogens also results in an increase in cerebellar blood flow in post-menopausal women [64]. …”

Section: Health Implicationsmentioning

confidence: 99%

The cerebellum as a target for estrogen action

Hedges

Ebner

Meisel

et al. 2012

Frontiers in Neuroendocrinology

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This review focuses on the effects of estrogens upon the cerebellum, a brain region long ignored as a site of estrogen action. Highlighted are the diverse effects of estradiol within the cerebellum, emphasizing the importance of estradiol signaling in cerebellar development, modulation of synaptic neurotransmission in the adult, and the potential influence of estrogens on various health and disease states. We also provide new data, consistent with previous studies, in which locally synthesized estradiol modulates cerebellar glutamatergic neurotransmission, providing one underlying mechanism by which the actions of estradiol can affect this brain region.

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Section: Health Implicationsmentioning

confidence: 99%

The cerebellum as a target for estrogen action

Hedges

Ebner

Meisel

et al. 2012

Frontiers in Neuroendocrinology

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“…However, the mechanism of cognitive impairment in older females is complex and not yet fully understood. To the best of our knowledge, prior to this study, there have not been any resting-state LFF studies on older females (i.e., postmenopausal women) with MCI, although the increases of cerebral blood flow in different brain areas during the performance of memory tasks in postmenopausal women using positron emission tomography (PET) when compared to male subjects [18]. Amplitude of LFF (ALFF), in which the square root of the power spectrum is integrated in a low-frequency range, can be used to detect the regional intensity of spontaneous fluctuations in BOLD signal [19].…”

Section: Introductionmentioning

confidence: 99%

Identifying brain functional alterations in postmenopausal women with cognitive impairment

et al. 2015

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“…HT can also enhance neurotransmitter functions, including cholinergic activity, through increased activation of estrogen receptors [35], which are found in higher concentrations intraneuronally in the basal forebrain, frontal lobe and locus coeruleus [36]. Accordingly, HT has been associated with increased brain activation and cerebral blood flow in multiple cortical regions [36–38], including those involved in semantic learning and retrieval.…”

Section: Discussionmentioning

confidence: 99%

Language Performance in Postmenopausal Women with and without Hormone Therapy and Men

et al. 2012

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Aims In the current study, we explored the potential effects of hormone therapy (HT) on language functioning in healthy, postmenopausal women and compared them with men of similar ages. Materials & methods Language functioning on tasks of verbal fluency and object naming was examined in 100 participants (mean age: 61.9 years; 33 HT users, 15 HT non-users and 52 men) at baseline and follow-up (mean follow-up time period: 2.6 years). Results At baseline, men had higher composite language scores than HT users. However, HT users demonstrated more improvement over time compared with men, whereas HT non-users performed similarly to men, with no improvement over time. Longer duration of HT use was not associated with improved performance on language tests. Conclusion These results suggest an association between HT use and better language ability in postmenopausal women.

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Acute effect of intranasal estrogen on cerebral and cerebellar perfusion in postmenopausal women

Cited by 17 publications

References 48 publications

The cerebellum as a target for estrogen action

The cerebellum as a target for estrogen action

Identifying brain functional alterations in postmenopausal women with cognitive impairment

Language Performance in Postmenopausal Women with and without Hormone Therapy and Men

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