Acute effect of high-intensity interval exercise on vascular endothelial function and possible mechanisms of wall shear stress in young obese males

Shi, Wenxia; Liu, Haibin; Cao, Ling; He, Yufeng; Su, Pei; Chen, Jiangang; Wang, Mengyue; Li, Xulong; Bai, Song; Tang, Donghui

doi:10.3389/fphys.2022.966561

Cited by 5 publications

(5 citation statements)

References 43 publications

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“…Exercise promotes cardiovascular health partly through its influence on endothelial function by increasing shear stress-a mechanical force exerted by flowing blood on the vascular wall [49,[99][100][101][102][103]. This shear stress is crucial for maintaining endothelial health, including attenuating oxidative stress and limiting endothelial senescence, a factor in aging and disease progression [104][105][106].…”

Section: Potential Pathways Underlying the Association Between Crf An...mentioning

confidence: 99%

Unraveling the link between cardiorespiratory fitness and cancer: a state-of-the-art review

Kunutsor,

Kaminsky,

Lehoczki

et al. 2024

GeroScience

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Cardiorespiratory fitness (CRF) not only reflects an individual’s capacity to perform physical activities but also encapsulates broader effects on the basic biology of aging. This review aims to summarize the evidence on the influence of CRF on overall and site-specific cancer risks. It delves into the biological mechanisms through which CRF may exert its effects, explores the clinical implications of these findings, identifies gaps in the current evidence base, and suggests directions for future research. The synthesis of findings reveals that higher CRF levels (general threshold of > 7 METs) are consistently associated with a reduced risk of a range of cancers, including head and neck, lung, breast, gastrointestinal, particularly pancreatic and colorectal, bladder, overall cancer incidence and mortality, and potentially stomach and liver, bile duct, and gall bladder cancers. These inverse associations between CRF and cancer risk do not generally differ across age groups, sex, race, or adiposity, suggesting a universal protective effect of CRF. Nonetheless, evidence linking CRF with skin, mouth and pharynx, kidney, and endometrial cancers is limited and inconclusive. Conversely, higher CRF levels may be potentially linked to an increased risk of prostate cancer and hematological malignancies, such as leukemia and myeloma, although the evidence is still not conclusive. CRF appears to play a significant role in reducing the risk of several cancers through various biological mechanisms, including inflammation reduction, immune system enhancement, hormonal regulation, and metabolic improvements. Overall, enhancing CRF through regular physical activity offers a vital, accessible strategy for reducing cancer risk and extending the health span. Future research should aim to fill the existing evidence gaps regarding specific cancers and elucidate the detailed dose–response relationships between CRF levels and cancer risk. Studies are also needed to elucidate the causal relationships and mechanistic pathways linking CRF to cancer outcomes.

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Section: Potential Pathways Underlying the Association Between Crf An...mentioning

confidence: 99%

Unraveling the link between cardiorespiratory fitness and cancer: a state-of-the-art review

Kunutsor,

Kaminsky,

Lehoczki

et al. 2024

GeroScience

View full text Add to dashboard Cite

show abstract

“…A greater increase in BP and muscle sympathetic nerve activity in response to static exercise has been described in young otherwise healthy adults with a family history of hypertension as compared to controls matched for age, BP and heart rate [ 29 ]. Endothelium-dependent vasodilation in large arteries represents a key adaptive response to systolic wall shear stress occurring during physical exercise [ 30 ]. Thus, endothelial dysfunction by impairing the physiological vasodilation that counterbalances the increased shear stress, may trigger EBPR.…”

Section: Mechanismsmentioning

confidence: 99%

Clinical and Prognostic Value of Exaggerated Blood Pressure Response to Exercise

Cuspidi¹,

Faggiano²,

Gherbesi³

et al. 2023

Rev. Cardiovasc. Med.

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The hypertensive response to exercise testing, defined as exaggerated blood pressure response (EBPR), has been documented to be independently associated with unhealthy conditions, carrying an increased risk of future hypertension, cardiovascular (CV) morbidity and mortality. In treated hypertensives, EBPR is a marker of uncontrolled hypertension, a condition previously undetected by office blood pressure (BP) measurements at rest; EBPR may also detect masked hypertension, a phenotype characterized by normal BP values in the medical environment but elevated home or ambulatory BP monitoring (ABPM). The aim of the present review is to provide a comprehensive and up-dated information on the clinical importance of EBPR targeting the following issues: (I) definition and prevalence; (II) underlying mechanisms; (III) clinical correlates and association with subclinical organ damage; (IV) predictive value; (V) clinical decision making.

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“…Acute and long-term moderate-intensity exercise and acute HIIE intervention augment perfusion, alter hemodynamic signaling, and induce the upregulation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway by increasing the frequency and amplitude of shear stress acting on the eNOS Ser1177 phosphorylation at the vascular wall. Furthermore, this activity activates and increases endogenous NO bioavailability and reduces ET-1 production, thereby improving vascular tone and arterial endothelial function [ 48 , 49 , 50 , 51 ]. In contrast, acute high-intensity sustained exercise can uncouple eNOS, leading to a further drop in NO production as well as an elevation in ET-1 concentrations [ 30 , 33 ].…”

Section: Potential Mechanisms By Which Exercise Of Different Intensit...mentioning

confidence: 99%

Advancements in the Regulation of Different-Intensity Exercise Interventions on Arterial Endothelial Function

Li,

Qin,

Zhang

et al. 2023

Rev. Cardiovasc. Med.

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Normal-functioning endothelium is crucial to maintaining vascular homeostasis and inhibiting the development and progression of cardiovascular diseases such as atherosclerosis. Exercise training has been proven effective in regulating arterial endothelial function, and the effect of this regulation is closely related to exercise intensity and the status of arterial endothelial function. With this review, we investigated the effects of the exercise of different intensity on the function of arterial endothelium and the underlying molecular biological mechanisms. Existing studies indicate that low-intensity exercise improves arterial endothelial function in individuals who manifest endothelial dysfunction relative to those with normal endothelial function. Most moderate-intensity exercise promotes endothelial function in individuals with both normal and impaired arterial endothelial function. Continuous high-intensity exercise can lead to impaired endothelial function, and high-intensity interval exercise can enhance both normal and impaired endothelial function. In addition, it was demonstrated that the production of vasomotor factors, oxidative stress, and inflammatory response is involved in the regulation of arterial endothelial function under different-intensity exercise interventions. We posit that this synthesis will then provide a theoretical basis for choosing the appropriate exercise intensity and optimize the prescription of clinical exercise for persons with normal and impaired endothelium.

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Acute effect of high-intensity interval exercise on vascular endothelial function and possible mechanisms of wall shear stress in young obese males

Abstract: Acute effect of high-intensity interval exercise on vascular endothelial function and possible mechanisms of wall shear stress in young obese males.

Cited by 5 publications

References 43 publications

Unraveling the link between cardiorespiratory fitness and cancer: a state-of-the-art review

Unraveling the link between cardiorespiratory fitness and cancer: a state-of-the-art review

Clinical and Prognostic Value of Exaggerated Blood Pressure Response to Exercise

Advancements in the Regulation of Different-Intensity Exercise Interventions on Arterial Endothelial Function

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