Acute effect of callosotomy on cortical temporal coupling in humans: Intraoperative electrocorticographic recording

Rojas-Ramos, Olga A.; Ondarza, Rodolfo; Ramos-Loyo, Julieta; Trejo-Martínez, David; Río-Portilla, Yolanda del; Guevara, Miguel Ángel; Corsi-Cabrera, María

doi:10.1016/j.clinph.2013.04.334

Cited by 8 publications

(14 citation statements)

References 55 publications

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“…Because of the small number of subjects, results from all eye movements were entered into a fixed‐effects model with the four time windows as repeated measures considered separately for REM and waking eye movements, followed by two planned comparisons between the time windows of interest: one from −500 to −250 and −250 to 0 and the other from −250 to 0 and 0 to 250 ms (Meletti et al ., ; Rojas‐Ramos et al ., ). Subsidiary analyses were conducted for each patient to assess the reliability of the results obtained in the group analysis.…”

Section: Methodsmentioning

confidence: 99%

Human amygdala activation during rapid eye movements of rapid eye movement sleep: an intracranial study

Corsi-Cabrera

Velasco

Río-Portilla

et al. 2016

Journal of Sleep Research

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The amygdaloid complex plays a crucial role in processing emotional signals and in the formation of emotional memories. Neuroimaging studies have shown human amygdala activation during rapid eye movement sleep (REM). Stereotactically implanted electrodes for presurgical evaluation in epileptic patients provide a unique opportunity to directly record amygdala activity. The present study analysed amygdala activity associated with REM sleep eye movements on the millisecond scale. We propose that phasic activation associated with rapid eye movements may provide the amygdala with endogenous excitation during REM sleep. Standard polysomnography and stereo-electroencephalograph (SEEG) were recorded simultaneously during spontaneous sleep in the left amygdala of four patients. Time-frequency analysis and absolute power of gamma activity were obtained for 250 ms time windows preceding and following eye movement onset in REM sleep, and in spontaneous waking eye movements in the dark. Absolute power of the 44-48 Hz band increased significantly during the 250 ms time window after REM sleep rapid eye movements onset, but not during waking eye movements. Transient activation of the amygdala provides physiological support for the proposed participation of the amygdala in emotional expression, in the emotional content of dreams and for the reactivation and consolidation of emotional memories during REM sleep, as well as for next-day emotional regulation, and its possible role in the bidirectional interaction between REM sleep and such sleep disorders as nightmares, anxiety and post-traumatic sleep disorder. These results provide unique, direct evidence of increased activation of the human amygdala time-locked to REM sleep rapid eye movements.

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Section: Methodsmentioning

confidence: 99%

Human amygdala activation during rapid eye movements of rapid eye movement sleep: an intracranial study

Corsi-Cabrera

Velasco

Río-Portilla

et al. 2016

Journal of Sleep Research

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“…Axons of the CC are diffusely arborized such that they have both interhemispheric and intrahemispheric targets [33,34]. A recent study using direct intracranial recordings before and after callosotomy demonstrated a reduction in temporal coupling between intrahemispheric recording sites immediately after callosotomy [21]. Interestingly, both simple partial and complex partial seizures have been shown to decrease in frequency after callosal section [18], which also supports the idea that the CC mediates intrahemispheric synchronization.…”

Section: Corpus Callosotomy Alters the Dynamics Of Seizure Propagationmentioning

confidence: 59%

“…Understanding the mechanisms by which the CC facilitates cerebral connectivity illuminates how callosotomy facilitates EZ localization. The CC is the largest of seven interhemispheric white matter tracts and connects approximately 80% of cerebral cortex [19] and therefore plays a major role in cortico-cortical interhemispheric communication [21]. Interhemispheric communication by the CC is necessary for basic human cognitive function as evidenced by disconnection syndromes, which are seen following corpus callosotomy and also in agenesis of the CC [27][28][29].…”

Section: Corpus Callosotomy Alters the Dynamics Of Seizure Propagationmentioning

confidence: 99%

“…The CC is an important mediator of not only interhemispheric synchronization but also intrahemispheric synchronization [21,31,32]. Axons of the CC are diffusely arborized such that they have both interhemispheric and intrahemispheric targets [33,34].…”

Section: Corpus Callosotomy Alters the Dynamics Of Seizure Propagationmentioning

confidence: 99%

“…Approximately 80% of the cerebral cortex is connected through the corpus callosum (CC), which connects symmetrical contralateral regions of cortex [19]. As a result, the CC plays a crucial role in seizure bilateralization, bisynchronization, and potentially intrahemispheric seizure spread [19][20][21]. It has long been recognized that section of the CC alters the propagation of epileptiform activity [7] and has the potential to reveal localized epileptic foci amenable to surgical resection [22].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Combined corpus callosotomy and intracranial recordings to localize the epileptogenic zone in children

2015

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Corpus callosotomy, or surgical disconnection of the corpus callosum, is an operation used for patients with medically intractable epilepsy that reduces seizure frequency and severity in a number of different seizure types, particularly drop attacks. Though typically thought of as a palliative operation for epilepsies without a localizable epileptic focus, previous work has demonstrated that callosotomy alters the dynamics of seizure spread and in some cases can reveal previously undiscovered epileptic foci on follow-up electroencephalography or electrocorticography. In recent years, several case reports and case series demonstrate use of callosotomy as an aid to seizure localization in cases where traditional techniques have failed. In this manuscript, we describe the emerging literature describing callosotomy as an aid to seizure localization.

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Incremental changes in interhemispheric functional connectivity after two-stage corpus callosotomy in a patient with subcortical band heterotopia

Matsuhashi

Matsuo

Kumada

2022

Epilepsy & Behavior Reports

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Highlights Coherence calculated from scalp EEG may be utilized to evaluate functional connectivity. Functional connectivity decreased stepwise after anterior/posterior callosotomy. Correlation was seen between functional connectivity and seizure frequency change. Functional connectivity may reflect seizure outcome of callosotomy.

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Acute effect of callosotomy on cortical temporal coupling in humans: Intraoperative electrocorticographic recording

Cited by 8 publications

References 55 publications

Human amygdala activation during rapid eye movements of rapid eye movement sleep: an intracranial study

Human amygdala activation during rapid eye movements of rapid eye movement sleep: an intracranial study

Combined corpus callosotomy and intracranial recordings to localize the epileptogenic zone in children

Incremental changes in interhemispheric functional connectivity after two-stage corpus callosotomy in a patient with subcortical band heterotopia

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