Acute Effect of Auricular Vagus Nerve Stimulation on Cycle Ergometer Test and Physiological Parameters in Healthy Young Individuals

Hatik, Sefa Haktan

doi:10.46998/ijcmcr.2021.15.000360

Cited by 1 publication

(1 citation statement)

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“…In healthy participants, transvenous VNS was insufficient to modulate the innate immune response during endotoxemia (Kox et al, 2015 ). Short-term non-invasive auricular VNS did not significantly affect the motor performance of young healthy individuals in the cycle ergometer test (Hatik et al, 2022 ). Short trains of taVNS decreased the heart rate in a stimulation parameter-dependent manner (Badran et al, 2018 ).…”

Section: Clinical Implications Of Vnsmentioning

confidence: 99%

Neuroimmunomodulation of vagus nerve stimulation and the therapeutic implications

Fang

Lin

Tseng

et al. 2023

Front. Aging Neurosci.

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Vagus nerve stimulation (VNS) is a technology that provides electrical stimulation to the cervical vagus nerve and can be applied in the treatment of a wide variety of neuropsychiatric and systemic diseases. VNS exerts its effect by stimulating vagal afferent and efferent fibers, which project upward to the brainstem nuclei and the relayed circuits and downward to the internal organs to influence the autonomic, neuroendocrine, and neuroimmunology systems. The neuroimmunomodulation effect of VNS is mediated through the cholinergic anti-inflammatory pathway that regulates immune cells and decreases pro-inflammatory cytokines. Traditional and non-invasive VNS have Food and Drug Administration (FDA)-approved indications for patients with drug-refractory epilepsy, treatment-refractory major depressive disorders, and headaches. The number of clinical trials and translational studies that explore the therapeutic potentials and mechanisms of VNS is increasing. In this review, we first introduced the anatomical and physiological bases of the vagus nerve and the immunomodulating functions of VNS. We covered studies that investigated the mechanisms of VNS and its therapeutic implications for a spectrum of brain disorders and systemic diseases in the context of neuroimmunomodulation.

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Section: Clinical Implications Of Vnsmentioning

confidence: 99%