2018
DOI: 10.1152/jn.00579.2018
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Acute dopamine receptor blockade in substantia nigra pars reticulata: a possible model for drug-induced Parkinsonism

Abstract: Acute dopamine receptor blockade in substantia nigra pars reticulata: a possible model for drug-induced Parkinsonism. Dopamine (DA) depletion modifies the firing pattern of neurons in the substantia nigra pars reticulata (SNr), shifting their mostly tonic firing toward irregularity and bursting, traits of pathological firing underlying rigidity and postural instability in Parkinson's disease (PD) patients and animal models of Parkinsonism (PS). Drug-induced Parkinsonism (DIP) represents 20 -40% of clinical cas… Show more

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Cited by 14 publications
(9 citation statements)
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“…Inhibition of these receptors led to a reduction in firing rate and an increase in the irregularity of ISI, which may imply that in dopamine depleted rats, there was no dendritic release of dopamine, no TRPC3 enhancement and thus a reduction in the spontaneous firing rate in comparison to the naïve rats. These findings are also in line with recent work showing a reduction in firing rate, under two conditions; namely, the blockage of D 1 and D 2 receptors and experimental Parkinsonism in juvenile mice (Cáceres-Chávez et al, 2018). We also identified an increase in irregularity, as did Zhou et al (2009).…”
Section: Discussionsupporting
confidence: 92%
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“…Inhibition of these receptors led to a reduction in firing rate and an increase in the irregularity of ISI, which may imply that in dopamine depleted rats, there was no dendritic release of dopamine, no TRPC3 enhancement and thus a reduction in the spontaneous firing rate in comparison to the naïve rats. These findings are also in line with recent work showing a reduction in firing rate, under two conditions; namely, the blockage of D 1 and D 2 receptors and experimental Parkinsonism in juvenile mice (Cáceres-Chávez et al, 2018). We also identified an increase in irregularity, as did Zhou et al (2009).…”
Section: Discussionsupporting
confidence: 92%
“…We also identified an increase in irregularity, as did Zhou et al (2009). In contrast to in vivo studies that have reported an increase in the bursting activity of SNr neurons (Murer et al, 1997; Lee et al, 2001; Wang et al, 2010b; Cáceres-Chávez et al, 2018), we rarely encountered bursting activity, which may be due to the use of blockers for glutamatergic inputs in our experiments (Ibáñ Ez-Sandoval et al, 2007; Aceves et al, 2011).…”
Section: Discussioncontrasting
confidence: 88%
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“…Interestingly, this effect was mimicked by artificially elevating ambient DA levels, which supports its physiological and functional relevance [178]. In addition, acute blockade of D1-like and D2-like receptors induces hyperpolarization of SNr neurons and a switch from tonic regular firing to irregular or burst firing [47]. This pharmacological manipulation resembles the activity of SNr neurons recorded in vivo in anesthetized [179,180,181,182] and awake [183] DD rodents.…”
Section: The Substantia Nigra Pars Reticulatamentioning
confidence: 92%
“…DA release has also been measured in the STN upon electrical stimulation of dopaminergic inputs using fast-scan voltammetry [43]. In addition, DA receptors are expressed in all ESN (for a review, see [46]), and local applications of dopaminergic receptor agonists and antagonists locally in various ESN affect the neuronal activity of these nuclei [47,48,49,50]. All these data suggest that DA participates in the normal function of the ESN by regulating both cellular excitability and synaptic transmission.…”
Section: Extra-striatal Nuclei Neurons Share Specific Featuresmentioning
confidence: 99%