Acute Disseminated Paracoccidioidomycosis with Molluscoid Lesions in a Young Woman

Ortíz, Beatriz Di Martino; Moreno, Tatiana; Galeano, G.; Rodríguez, Mirtha

doi:10.1016/j.adengl.2015.06.016

Cited by 1 publication

(2 citation statements)

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“…The signs and symptoms presented by the majority of the patients from this cohort were related to the reticuloendothelial system, corresponding to the findings of other authors . Disseminated lethal cases affecting unusual organs and tissues with no clinical evidence were also observed in this study, confirming that the yeasts are capable to invade every tissue of the human body …”

Section: Discussionsupporting

confidence: 90%

“…Patients with acute‐subacute PCM present disseminated fungal infection, frequently involving the phagocytic‐mononuclear system and leading to generalised lymphadenopathy and hepatosplenomegaly . The laboratorial typical findings are anaemia, eosinophilia, hypoalbuminemia and hypergammaglobulinemia, with high antibody titres in serologic tests …”

Section: Introductionmentioning

confidence: 99%

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Acute‐subacute paracoccidioidomycosis: A paediatric cohort of 141 patients, exploring clinical characteristics, laboratorial analysis and developing a non‐survival predictor

Romaneli

Tardelli

Tresoldi

et al. 2019

Mycoses

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Summary The acute‐subacute form of paracoccidioidomycosis (PCM) is a severe systemic mycosis that affects children and adolescents from endemic regions, leading to generalised lymphadenopathy, fever, weight loss, anaemia, eosinophilia, hypoalbuminemia and hypergammaglobulinemia. The objective of this study is to describe the clinical and laboratorial characteristics of acute‐subacute PCM, to determine a mortality risk factor and to propose a test for non‐survival hazard related to the disease. Children and adolescents diagnosed with PCM, under 15 years were included in the study. Their epidemiological, clinical and laboratorial data were obtained from the hospital records. Descriptive analysis, comparison of means, univariate logistic regression, multivariate logistic regression and a ROC curve were performed in order to identify significant information (P < .05). Through a period of 38 years, 141 children and adolescents were diagnosed with acute‐subacute PCM. The main antifungal agent used for the treatment was sulfamethoxazole‐trimethoprim (SMX‐TMP). The complication rate was 17%, the relapse rate was 7.8% and the mortality rate was 5.7%. A low albumin dosage was identified as a predictor factor for mortality. The cut‐off for serum albumin was 2.18 g/dL, above which, the survival rate is 99.1%. Thus, simple clinical and laboratorial examinations may lead to the diagnosis of acute‐subacute PCM, and the beginning of the treatment is encouraged even before the isolation of the fungus in biological samples, preventing unfavourable outcomes. Patients with an albumin dosage ≤ 2.18g/dL must receive special attention, preferably hospitalised, during the first four weeks of treatment for presenting an elevated mortality hazard.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%