Acute Disseminated Encephalomyelitis

Coyle, Patricia K.

doi:10.1007/978-1-60327-860-7_11

Cited by 1 publication

(4 citation statements)

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“…Reported annual incidences of this disease in developed countries have ranged from 0.07 to 0.8/100 000 with the average age of onset between 6 and 8 years. However, the disease is much less common in children below 2 years of age 2 3 – 7…”

Section: Discussionmentioning

confidence: 99%

“…However, impaired level of consciousness (drowsiness, lethargy, stupor or coma) is a key feature 3. At least 70% of patients report an antecedent prodromal event 2–30 days prior to the onset of ADEM symptoms 3…”

Section: Discussionmentioning

confidence: 99%

“…Instead, it is treated similar to MS and other autoimmune diseases. Based on the clinician's expertise and data from small series, different immunosuppressive approaches are pursued for different cases of ADEM and these include steroids, intravenous immunoglobulin (IVIg) or plasmapheresis 2 3…”

Section: Discussionmentioning

confidence: 99%

“…Mortality from ADEM in the paediatric population has been reported at rates from 0% to less than 5% in more recent studies. However, permanent cognitive and neurological deficits could be seen in 10–30% of patients 3 10. Close neurological follow-up is thus warranted.…”

Section: Discussionmentioning

confidence: 99%

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Acute disseminated encephalomyelitis following infectious mononucleosis in a toddler

et al. 2013

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SUMMARYSymptomatic Epstein-Barr virus (EBV) infection complicated by acute disseminated encephalomyelitis (ADEM) in a toddler is rare. Our patient is a 14 month-old boy who presented with listlessness and reduced eye movements nearly 10 days after a prodromal upper respiratory illness that was accompanied by an amoxicillin rash. On examination, the boy appeared drowsy, had a congested throat and a resolving lower extremity rash, but otherwise had a normal neurological examination. Investigation revealed lymphocytosis, mildly elevated liver enzyme and a positive EBV IgM serology. Cerebrospinal fluid analysis showed pleocytosis. Subsequent brain and spine MRI showed demyelinating disease extending from the cerebral peduncles, across the brain stem and down to the mid-thoracic spinal cord. The patient was treated as a case of ADEM and given intravenous methylprednisolone. On outpatient follow-up his symptoms resolved completely in 6 weeks. BACKGROUND

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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