Acute Disseminated Encephalomyelitis Associated With Influenza A H1N1 Infection

Özkale, Yasemin; Erol, İlknur; Özkale, Murat; Demır, Şenay; Alehan, Füsun

doi:10.1016/j.pediatrneurol.2012.03.019

Cited by 20 publications

(17 citation statements)

References 13 publications

(17 reference statements)

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“…Most infections of influenza virus A are localized to the upper respiratory tract but some more severe cases may result in pneumonia (Nicholson et al, 2003) and even complications involving the CNS (Jang et al, 2009). Several studies have shown that influenza A can be associated with encephalitis, Reye's syndrome, febrile seizure, acute necrotizing encephalopathy, and possibly acute disseminated encephalomyelitis (ADEM) in humans (Millichap and Millichap, 2006;Ozkale et al, 2012;Toovey, 2008;Wang et al, 2010;Zeng et al, 2013). Making use of murine models, it has also been shown that influenza A virus could reach the CNS through the olfactory nerve route and alter hippocampal morphology or expression of synaptic regulatory genes while impairing cognition and emotional behavior (Beraki et al, 2005;Jurgens et al, 2012).…”

Section: Respiratory Viruses With Neuroinvasive and Neurotropic Propementioning

confidence: 99%

Human coronaviruses: Viral and cellular factors involved in neuroinvasiveness and neuropathogenesis

et al. 2014

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Among the various respiratory viruses infecting human beings, coronaviruses are important pathogens, which usually infect the upper respiratory tract, where they are mainly associated with common colds. However, in more vulnerable populations, such as newborns, infants, the elderly and immune-compromised individuals, these opportunistic pathogens can also affect the lower respiratory tract, leading to pneumonia, exacerbations of asthma, and various types of respiratory distress syndrome. The respiratory involvement of human coronaviruses has been clearly established since the 1960s. Nevertheless, for almost three decades now, data reported in the scientific literature has also demonstrated that, like it was described for other human viruses, coronaviruses have neuroinvasive capacities since they can spread from the respiratory tract to the central nervous system (CNS). Once there, infection of CNS cells (neurotropism) could lead to human health problems, such as encephalitis and long-term neurological diseases. Neuroinvasive coronaviruses could damage the CNS as a result of misdirected host immune responses that could be associated with autoimmunity in susceptible individuals (virus-induced neuroimmunopathology) and/or viral replication, which directly induces damage to CNS cells (virus-induced neuropathology). Given all these properties, it has been suggested that these opportunistic human respiratory pathogens could be associated with the triggering or the exacerbation of neurologic diseases for which the etiology remains poorly understood. Herein, we present host and viral factors that participate in the regulation of the possible pathogenic processes associated with CNS infection by human coronaviruses and we try to decipher the intricate interplay between virus and host target cells in order to characterize their role in the virus life cycle as well as in the capacity of the cell to respond to viral invasion.

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Section: Respiratory Viruses With Neuroinvasive and Neurotropic Propementioning

confidence: 99%

Human coronaviruses: Viral and cellular factors involved in neuroinvasiveness and neuropathogenesis

et al. 2014

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“…El espectro de secuelas neurológicas incluyen cuadriparesia (12) , hemiplejía e hipertonía de extremidades (13) . En relación con el uso de oseltamivir, se han descrito casos con evolución favorable sin el uso del antiviral (14) ; así como pacientes con recuperación completa, en los cuales se administró oseltamivir (15) .…”

Section: Discussionunclassified

Encefalopatía no fatal por influenza AH1N1 en paciente pediátrico

Valdivia-Tapia¹,

Carreazo

2016

Rev Peru Med Exp Salud Publica

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RESUMENNiña de dos años con fiebre y síntomas catarrales que presenta convulsiones focales de hemicuerpo derecho, las cuales persisten adicionándose signos de hipertensión endocraneana. Se identifica Influenza AH1N1 mediante reacción de cadena de polimerasa en hisopado nasofaríngeo. Paciente evoluciona favorablemente con medidas de soporte. No recibió Oseltamivir.Palabras clave: Encefalitis viral; subtipo H1N1 del virus de la Infuenza A; Oseltamivir; preescolar (fuente: DeCS BIREME). NON-FATAL CASE OF H1N1 INFLUENZA ENCEPHALOPATHY IN A PEDIATRIC PATIENT ABSTRACTA 2-year-old girl presented with fever, catarrhal symptoms, and focal right hemispheric seizures that persisted and led to signs of intracranial hypertension. An influenza A H1N1 infection was confirmed via polymerase chain reaction analysis of a nasopharyngeal swab. The patient, who was not treated with oseltamavir, has responded favorably to supportive measures.

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“…5,6 It is one of the many syndromes that can develop after vaccination or a microbial infection, and has a 2-to 30-day latency period. 3,7 The typical MRI appearance is of demyelinating lesions preferentially affecting white matter tracts in a periventricular distribution.…”

Section: Discussionmentioning

confidence: 99%

Tumefactive acute disseminated encephalomyelitis complicating human swine influenza (H1N1)

Chan

2014

Hong Kong Med J

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Acute Disseminated Encephalomyelitis Associated With Influenza A H1N1 Infection

Cited by 20 publications

References 13 publications

Human coronaviruses: Viral and cellular factors involved in neuroinvasiveness and neuropathogenesis

Human coronaviruses: Viral and cellular factors involved in neuroinvasiveness and neuropathogenesis

Encefalopatía no fatal por influenza AH1N1 en paciente pediátrico

Tumefactive acute disseminated encephalomyelitis complicating human swine influenza (H1N1)

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