Acute disseminated encephalomyelitis associated with poliomyelitis vaccine

Ozawa, Hiroshi; Noma, Seiji; Yoshida, Yasuko; Sekine, Hiromasa; Hashimoto, Toshiaki

doi:10.1016/s0887-8994(00)00167-3

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Poliomyelitis Is Caused By Poliovirus Infection and Is Char1

Discussion1

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2022

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Cited by 44 publications

(23 citation statements)

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“…, and acute disseminated encephalomyelitis (ADEM) associated with OPV has also been described in one report (4). We describe a patient with acute paresis and brain MRI abnormalities after OPV intake.…”

Section: Poliomyelitis Is Caused By Poliovirus Infection and Is Charmentioning

confidence: 75%

Acute Disseminated Encephalomyelitis Associated with Oral Polio Vaccine

et al. 2006

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Section: Poliomyelitis Is Caused By Poliovirus Infection and Is Charmentioning

confidence: 75%

Acute Disseminated Encephalomyelitis Associated with Oral Polio Vaccine

et al. 2006

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“…This indicates that the mechanism of this meningitis could have resulted from the reversion of the virus during replication in the other vaccine recipients [6][7][8][9]. Ozawa et al [10] reported acute disseminated encephalomyelitis (ADEM) associated with polio vaccine due to neurovilurent mutations of the virus. The several nucleotide changes observed in this strain and our strain could be the candidates for the research of the genetic basis of the poliovirus virulence.…”

Section: Discussionmentioning

confidence: 99%

Reversion to the Neurovilurent Genome Sequence of Polio Vaccine Virus Isolated from Community-Acquired Meningitis

Kato¹,

Shimada²,

Ishiko³

et al. 2009

TOPEDJ

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Neurologic complication associated with the use of live attenuated oral poliomyelitis vaccine is uncommon, but vaccine-associated paralytic poliomyelitis in recipients or contacts has sometimes been reported. We report here a community-acquired aseptic meningitis case and the genetic investigation of the isolated poliovirus type 2. The results of the genetic analysis indicate that the mechanism of this meningitis could be the result of the reversion of the virus during replication in the other vaccine recipients, suggesting a quest for revising the current vaccination program.

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“…Enteroviral associated ADEM has been reported by Ozawa et al [7] who described a case with a positive CSF culture for a mutated variant of the poliovirus serotype 2 vaccine strain and David et al [8] who reported a case associated with Coxsackie's B infection, while transverse myelitis has also been associated with Enterovirus 71 infection [9]. Clinical presentation of our case with presence of Enterovirus genome in CSF was initially highly suggestive of infective meningoencephalitis and a treatment with antibiotics and antivirals was started.…”

mentioning

confidence: 91%