Acute Dilantin poisoning

Acute diphenylhydantoin and primidone poisoning treated by peritoneal dialysis.

“…Theil et al (1961) have reported in detail the results of haemodialysis carried out in an 18 year-old woman 138 hours after a large overdose of diphenylhydantoin and phenobarbitone. The predialysis diphenylhydantoin blood level was 50 ttg/ml.…”

“…(Kutt, Winters, Kokenge, and McDowell, 1964). A number of patients are now known to have developed permanent cerebellar damage following both acute (Theil, Richter, Powell, and Doolan, 1961) and chronic (Utterback, 1958) diphenylhydantoin intoxication. The disturbances of cerebellar function were sometimes severe and the histological evidence in both man and animals that diphenylhydantoin produces Purkinje cell damage has been discussed by Kokenge, Kutt, and McDowell (1965).…”

Peritoneal Dialysis and Hemodialysis in Pregnancy

“…Hemodialysis was first used in pregnancy in 1961 for managing acute renal failure in a woman with acute phenytoin poisoning [1]. Other cases of acute renal failure requiring dialysis during pregnancy have subsequently been reported [2].…”

Hemodialysis During Pregnancy

“…No renal complications were reported in the mother during or after dialysis. 6 Herwig et al7 have recently performed repeated hemodialysis in an azotemic preg¬ nant woman with chronic renal disease during the last trimester with subsequent delivery by cesarean section of a viable pre¬ mature infant. Their patient and the new¬ born infant each had BUN levels of 56 mg/ 100 ml at the time of delivery.…”

“…[1][2][3][4][5] Only two reports are available of hemodialysis during pregnancy. [6][7] An opportunity was afforded to observe the subsequent course of a pregnancy following hemodialysis performed for the treatment of acute glutethimide (Doriden) intoxication during the 23rd to 24th week of gestation in a 21-year-old woman. Despite the development of acute renal failure, the patient's pregnancy proceeded normally.…”